Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics

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Synaptic plasticity and addiction

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Is there a common molecular pathway for addiction?

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Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

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Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

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Presynaptic nicotinic ACh receptors

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Damage to the insula disrupts addiction to cigarette smoking

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Effect of preoperative smoking intervention on postoperative complications: a randomised clinical trial

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Varenicline:  An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

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Brain nicotinic acetylcholine receptors: native subtypes and their relevance

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Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs

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Smoking and Major Depression: A Causal Analysis

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Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization

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Dramatic decreases in brain reward function during nicotine withdrawal

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Effect of Maintenance Therapy With Varenicline on Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

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Nicotine Metabolism and Intake in Black and White Smokers

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Novel genes identified in a high-density genome wide association study for nicotine dependence

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Molecular and cellular aspects of nicotine abuse

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Mortality following inpatient addictions treatment. Role of tobacco use in a community-based cohort

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Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

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Bupropion is a nicotinic antagonist

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The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease

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Familial Transmission of Substance Dependence: Alcohol, Marijuana, Cocaine, and Habitual Smoking

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Cellular and synaptic mechanisms of nicotine addiction

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Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity*1

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Cigarette smoking and cardiovascular disease: pathophysiology and implications for treatment

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Cardiovascular Toxicity of Nicotine: Implications for Nicotine Replacement Therapy 11All editorial decisions for this article, including selection of referees, were made by a Guest Editor. This policy applies to all articles with authors from the University of California San Francisco.

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Cellular mechanisms of nicotine addiction

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Female sex and oral contraceptive use accelerate nicotine metabolism

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Higher levels of nicotine in arterial than in venous blood after cigarette smoking

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Cigarette Smoking Saturates Brain α4β2 Nicotinic Acetylcholine Receptors

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Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine: implications for nicotine self-administration and reinforcement

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Cigarette smoking and diabetes

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Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation

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Nicotinic acetylcholine receptors as targets for antidepressants

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Implications of CYP2A6 Genetic Variation for Smoking Behaviors and Nicotine Dependence*

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The neurobiology of tobacco dependence: A preclinical perspective on the role of the dopamine projections to the nucleus

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Major depression following smoking cessation

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CRF–CRF ₁ system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats

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Nicotine Medications for Smoking Cessation

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Cigarette smoking and diabetes

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The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3 R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats

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Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat

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Dissociating nicotine and nonnicotine components of cigarette smoking

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Schizophrenia and the α7 Nicotinic Acetylcholine Receptor

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Functional brain imaging of tobacco use and dependence

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The Nicotinic Acetylcholine Receptor Subunit α5 Mediates Short-Term Effects of Nicotine in Vivo

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AR-R 17779, an α7 nicotinic agonist, improves learning and memory in rats

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Desensitized nicotinic receptors in brain

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Adverse pregnancy outcomes in snuff users

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Smoking and endothelial function

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Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs

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Nicotine and angiogenesis: a new paradigm for tobacco‐related diseases

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Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function

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Overview of the pharmacogenomics of cigarette smoking

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Individualizing Nicotine Replacement Therapy for the Treatment of Tobacco Dependence: A Randomized Trial

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Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems

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Repeated nicotine exposure enhances responding with conditioned reinforcement

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Genetics of nicotine dependence and pharmacotherapy

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Genetic analyses of DSM-IV nicotine withdrawal in adult twins

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Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell

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Clinical significance of tobacco withdrawal

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Non-Nicotinic Therapies for Smoking Cessation

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Tobacco-related disease mortality among men who switched from cigarettes to spit tobacco

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The risk of myocardial infarction and sudden cardiac death amongst snuff users with or without a previous history of smoking

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ROLE OF HUMAN CYTOCHROME P450 (CYP) IN THE METABOLIC ACTIVATION OF NITROSAMINE DERIVATIVES: APPLICATION OF GENETICALLY ENGINEEREDSALMONELLAEXPRESSING HUMAN CYP

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Cardiovascular responses to microinjections of nicotine into the caudal ventrolateral medulla of the rat

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NICOTINE EFFECTS ON WORKING MEMORY

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The Methylation Effect in Medicinal Chemistry

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Lung carcinogenesis by tobacco smoke

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Cognitive Effects of Nicotine

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Reward, addiction, withdrawal to nicotine

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One Is Not Enough: Understanding and Modeling Polysubstance Use

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Cognitive Effects of Nicotine: Recent Progress

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