The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update
Open accessAbstract
Biomarkers currently play an important role in the detection and management of patients with several different types of gastrointestinal cancer, especially colorectal, gastric, gastro‐oesophageal junction (GOJ) adenocarcinomas and gastrointestinal stromal tumors (GISTs). The aim of this article is to provide updated and evidence‐based guidelines for the use of biomarkers in the different gastrointestinal malignancies. Recommended biomarkers for colorectal cancer include an immunochemical‐based fecal occult blood test in screening asymptomatic subjects ≥50 years of age for neoplasia, serial CEA levels in postoperative surveillance of stage II and III patients who may be candidates for surgical resection or systemic therapy in the event of distant metastasis occurring, K‐RAS mutation status for identifying patients with advanced disease likely to benefit from anti‐EGFR therapeutic antibodies and microsatellite instability testing as a first‐line screen for subjects with Lynch syndrome. In advanced gastric or GOJ cancers, measurement of HER2 is recommended in selecting patients for treatment with trastuzumab. For patients with suspected GIST, determination of KIT protein should be used as a diagnostic aid, while KIT mutational analysis may be used for treatment planning in patients with diagnosed GISTs.
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Grading quality of evidence and strength of recommendations
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Cited by
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Self-citationBiomarker-guided therapy for colorectal cancer: strength in complexity
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Metadata
- Authors
- Duffy, M. J., Lamerz, R., Haglund, C., Nicolini, A., Kalousová, M., Holubec, L., & Sturgeon, C.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2013-08-27
- Volume
- 134
- Issue
- 11
- Pages
- 2513-2522
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1539249527
- Cited by
- 360
- References
- 126
- FWCI
- 14.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update. https://app.cochat.ai/papers/10.1002/ijc.28384
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- Duffy, M. J., Lamerz, R., Haglund, C., Nicolini, A., Kalousová, M., Holubec, L., & Sturgeon, C. (2014). Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update. International Journal of Cancer. https://doi.org/10.1002/ijc.28384
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
