The DOI matches its Crossref record; 160 of the 160 references it cites were found in a registry or an index.
Potentially malignant disorders of the oral cavity: Current practice and future directions in the clinic and laboratory
Abstract
Despite commendable progress in the prevention, detection, and treatment of a wide variety of solid tumor types, oral squamous cell carcinoma (OSCC) remains a significant health burden across the globe. OSCC carcinogenesis involves accumulation of genetic alterations that coincide with the multistep malignant transformation of normal oral epithelium. OSCC is often first diagnosed at late stages of the disease (advanced regional disease and/or metastasis). Delayed diagnosis precludes successful treatment and favorable outcomes. In clinical practice, opportunities exist to identify patients with oral potentially malignant disorders (OPMDs), which precede the development of cancer. This review addresses the current status of laboratory and clinical research on OPMDs, with emphasis on leukoplakia and erythroplakia. OSF is also presented, though there is a paucity of published studies on this disorder. We focus on findings that could translate into earlier diagnosis and more efficacious treatment of those lesions with significant malignant potential. We explore how markers of OPMD malignant transformation might be implemented into current diagnostic practice to help clinicians objectively stratify patients into treatment/follow‐up groups according to relative risk. We provide an overview of recently concluded and ongoing OPMD chemoprevention trials. We describe laboratory OPMD models that can be used to not only to reveal the genetic and molecular intricacies of oral cancer but also to develop novel screening methods and therapeutic approaches. Finally, we call for targeted screening programs of at‐risk populations in order to facilitate diagnosis and treatment of OPMD and early OSCC.
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“which from our previous project found no significant expression difference among the common epithelial markers in our past study and other previous study22–24.”
From High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa (2020) · cites this paper as [22]
In the citing paper
“The four were taken from three patients with an average age of 50, which were all diagnosed as hyperkeratosis without dysplasia by pathologists, just showing an increase in cell number in the spinous layer and/or in the basal/parabasal cell layers without cellular atypia, and its genetic profiles would be much more closed to normal tissue than malignant tissue22–24.”
From High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa (2020) · cites this paper as [22]
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Sorted by citations
High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa
Xu, H., Zhong, L., Deng, J., Peng, J., Dan, H., Zeng, X., Li, T., & Chen, Q. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0074-x · Cited by 2,838
Oral squamous cell carcinomas: state of the field and emerging directions
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Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy
Shih, Y.-H., Wang, T., Shieh, T., & Tseng, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122940 · Cited by 290
Ranganathan, K., & Kavitha, L. (2019) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/jomfp.jomfp_13_19 · Cited by 241
Cristaldi, M., Mauceri, R., Fede, O. D., Giuliana, G., Campisi, G., & Panzarella, V. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01476 · Cited by 202
Metadata
- Authors
- Dionne, K. R., Warnakulasuriya, S., Binti Zain, R., & Cheong, S. C.
- Affiliations
- University of Malaya (MY)
- King's College London (GB)
- Faculty of Dentistry Oral Cancer Research and Co‐ordinating Centre (OCRCC), University of Malaya Kuala Lumpur Malaysia
- Corresponding author
- Cheong, Sok Ching
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2014-02-11
- Volume
- 136
- Issue
- 3
- Pages
- 503-515
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2154220394
- Cited by
- 248
- References
- 160
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 17 · 2023: 24 · 2022: 32 · 2021: 29 · 2020: 30 · 2019: 20 · 2018: 17 · 2017: 19 · 2016: 21 · 2015: 17 · 2014: 6
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Health Sciences › Dentistry › General Dentistry › HIV/AIDS oral health manifestations
- Keywords
- oral potentially malignant disorders, oral squamous cell carcinoma, leukoplakia, erythroplakia, oral submucous fibrosis, chemoprevention, oral cancer screening, early diagnosis, oral carcinogenesis, oral epithelium, in vitro disease model
- MeSH terms
- Aged, Carcinoma, Squamous Cell, DNA, Humans, Leukoplakia, Oral, Male, Middle Aged, Mouth Neoplasms, Ploidies, Loss of Heterozygosity, Cyclin D1
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