The DOI matches its Crossref record; 160 of the 160 references it cites were found in a registry or an index.
Potentially malignant disorders of the oral cavity: Current practice and future directions in the clinic and laboratory
Abstract
Despite commendable progress in the prevention, detection, and treatment of a wide variety of solid tumor types, oral squamous cell carcinoma (OSCC) remains a significant health burden across the globe. OSCC carcinogenesis involves accumulation of genetic alterations that coincide with the multistep malignant transformation of normal oral epithelium. OSCC is often first diagnosed at late stages of the disease (advanced regional disease and/or metastasis). Delayed diagnosis precludes successful treatment and favorable outcomes. In clinical practice, opportunities exist to identify patients with oral potentially malignant disorders (OPMDs), which precede the development of cancer. This review addresses the current status of laboratory and clinical research on OPMDs, with emphasis on leukoplakia and erythroplakia. OSF is also presented, though there is a paucity of published studies on this disorder. We focus on findings that could translate into earlier diagnosis and more efficacious treatment of those lesions with significant malignant potential. We explore how markers of OPMD malignant transformation might be implemented into current diagnostic practice to help clinicians objectively stratify patients into treatment/follow‐up groups according to relative risk. We provide an overview of recently concluded and ongoing OPMD chemoprevention trials. We describe laboratory OPMD models that can be used to not only to reveal the genetic and molecular intricacies of oral cancer but also to develop novel screening methods and therapeutic approaches. Finally, we call for targeted screening programs of at‐risk populations in order to facilitate diagnosis and treatment of OPMD and early OSCC.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“which from our previous project found no significant expression difference among the common epithelial markers in our past study and other previous study22–24.”
From High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa (2020) · cites this paper as [22]
In the citing paper
“The four were taken from three patients with an average age of 50, which were all diagnosed as hyperkeratosis without dysplasia by pathologists, just showing an increase in cell number in the spinous layer and/or in the basal/parabasal cell layers without cellular atypia, and its genetic profiles would be much more closed to normal tissue than malignant tissue22–24.”
From High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa (2020) · cites this paper as [22]
Citations
Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C. D., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 21,468
Global Cancer Statistics, 2002
Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2005) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.55.2.74 · Cited by 18,710
Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20073 · Cited by 12,596
The molecular biology of head and neck cancer
Leemans, C. R., Braakhuis, B. J. M., & Brakenhoff, R. H. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2982 · Cited by 2,640
Cheng, A., Hsu, C., Lin, J., Hsu, M. M., Ho, Y., Shen, T. S., Ko, J. Y., Lin, J.-T., Lin, B., Ming-Shiang, W., et al. (2001) · PubMed · Cited by 2,071
Nomenclature and classification of potentially malignant disorders of the oral mucosa
Warnakulasuriya, S., Johnson, N. W., & van der Waal, I. (2007) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2007.00582.x · Cited by 1,804
Self-citationGenetic progression model for head and neck cancer: implications for field cancerization.
Califano, J. A., van der Riet, P., Westra, W. H., Nawroz, H., Clayman, G. L., Piantadosi, S., Corio, R. L., Lee, D. J., Greenberg, B. M., Koch, W. M., et al. (1996) · PubMed · Cited by 1,355
Herrero, R. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg107 · Cited by 1,230
Jemal, A., Clegg, L. X., Ward, E., Ries, L. A. G., Wu, X., Jamison, P. M., Wingo, P. A., Howe, H. L., Anderson, R. N., & Edwards, B. K. (2004) · Cancer · doi:10.1002/cncr.20288 · Cited by 1,141
Research works printed but not linked: 5
- Malaysia DDMoH, 1978, Dental epidemiological survey of adults in Peninsular Malaysia, 98
- Mehta FS, 1971, Report on oral cancer and precancerous conditions in Indian rural populations, 1966–1969
- Ministry of Health, 2009, National oral health survey, Sri Lanka (2002/2003)
- Warnakulasuriya S, 1998, Oral oncology
- Gopal Ray J, 2013, Pathogenesis and malignant transformation of oral submucous fibrosis: Possible role of lysly oxidase (lox) and NADPH quinone oxidoreductase 1 (NQO1) gene polymorphis. PhD Thesis
Cited by
Sorted by citations
High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa
Xu, H., Zhong, L., Deng, J., Peng, J., Dan, H., Zeng, X., Li, T., & Chen, Q. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0074-x · Cited by 2,838
Oral squamous cell carcinomas: state of the field and emerging directions
Tan, Y., Wang, Z., Xu, M., Li, B., Huang, Z., Qin, S., Nice, E. C., Tang, J., & Huang, C. (2023) · International Journal of Oral Science · doi:10.1038/s41368-023-00249-w · Cited by 988
Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy
Shih, Y.-H., Wang, T., Shieh, T., & Tseng, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122940 · Cited by 290
Ranganathan, K., & Kavitha, L. (2019) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/jomfp.jomfp_13_19 · Cited by 241
Cristaldi, M., Mauceri, R., Fede, O. D., Giuliana, G., Campisi, G., & Panzarella, V. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01476 · Cited by 202
Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments
Shen, Y., Shih, Y.-H., Fuh, L., & Shieh, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197231 · Cited by 171
Non–plaque‐induced gingival diseases
Holmstrup, P., Plemons, J. M., & Meyle, J. (2018) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12938 · Cited by 136
Non–plaque‐induced gingival diseases
Holmstrup, P., Plemons, J. M., & Meyle, J. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0163 · Cited by 112
Nikitakis, N. G., Pentenero, M., Georgaki, M., Poh, C. F.-Y., Peterson, D. E., Edwards, P. C., Lingen, M. W., & Sauk, J. J. (2018) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2018.03.012 · Cited by 98
Malignant transformation of oral submucous fibrosis: A systematic review and meta‐analysis
Kujan, O., Mello, F. W., & Warnakulasuriya, S. (2020) · Oral Diseases · doi:10.1111/odi.13727 · Cited by 99
Self-citationSalivary cytokines as biomarkers of oral cancer: a systematic review and meta-analysis
Chiamulera, M. M. A., Zancan, C. B., Remor, A. P., Cordeiro, M. F., Gleber‐Netto, F. O., & Baptistella, A. R. (2021) · BMC Cancer · doi:10.1186/s12885-021-07932-3 · Cited by 89
Surgical excision and follow-up of nondysplastic oral leukoplakia. A systematic review
Sato, H., Nakayama, H., Yagyuu, T., Abe, M., Suzuki, T., Takeda, D., Adachi, M., Yuasa, H., Uzawa, N., & Kurita, H. (2024) · Journal of Oral and Maxillofacial Surgery Medicine and Pathology · doi:10.1016/j.ajoms.2024.11.009 · Cited by 83
Malignant transformation rate of oral leukoplakia—systematic review
Pinto, A. C., Caramês, J., Francisco, H., Chen, A., Azul, A. M., & Marques, D. N. D. S. (2020) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2020.02.017 · Cited by 79
Long-term outcome of non-surgical treatment in patients with oral leukoplakia
Kuribayashi, Y., Tsushima, F., Morita, K., Matsumoto, K., Sakurai, J., Uesugi, A., Sato, K., Oda, S., Sakamoto, K., & Harada, H. (2015) · Oral Oncology · doi:10.1016/j.oraloncology.2015.09.004 · Cited by 75
Monteiro, L. S., Mello, F. W., & Warnakulasuriya, S. (2020) · Oral Diseases · doi:10.1111/odi.13747 · Cited by 72
Self-citationGrimm, M. R., Cetindis, M., Lehmann, M., Biegner, T., Munz, A., Teriete, P., Kraut, W., & Reinert, S. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-208 · Cited by 74
Alaizari, N., Sperandio, M., Odell, E. W., Peruzzo, D. C., & Al‐Maweri, S. A. (2017) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12603 · Cited by 67
Nagao, T., Warnakulasuriya, S., Nakamura, T., Kato, S., Yamamoto, K., Fukano, H., Suzuki, K. A. O., Shimozato, K., & Hashimoto, S. (2014) · International Journal of Cancer · doi:10.1002/ijc.29156 · Cited by 65
Self-citationLin, L.-H., Lin, J.-S., Yang, C.-C., Cheng, H.-W., Chang, K., & Liu, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072360 · Cited by 63
Sundberg, J., Korytowska, M., Holmberg, E. C., Bratel, J., Wallström, M., Kjellström, E., Blomgren, J., Kovács, A., Öhman, J. N., Sand, L. P., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0225682 · Cited by 62
The management of oral epithelial dysplasia: The Liverpool algorithm
Field, E. A., McCarthy, C., Ho, M. W. S., Rajlawat, B. P., Holt, D., Rogers, S. N., Triantafyllou, A. G., Field, J. K., & Shaw, R. (2015) · Oral Oncology · doi:10.1016/j.oraloncology.2015.06.015 · Cited by 60
The p38/MKP-1 signaling axis in oral cancer: Impact of tumor-associated macrophages
Li, Z., Liu, F., & Kirkwood, K. L. (2020) · Oral Oncology · doi:10.1016/j.oraloncology.2020.104591 · Cited by 58
Yamamoto, N., Kawaguchi, K., Fujihara, H., Hasebe, M., Kishi, Y., Yasukawa, M., Kumagai, K., & Hamada, Y. (2017) · International Journal of Oral Science · doi:10.1038/ijos.2017.37 · Cited by 59
Use of electrical impedance spectroscopy to detect malignant and potentially malignant oral lesions
Murdoch, C., D’Apice, K., Thornhill, M. H., Brown, B. H., Hearnden, V. L., Speight, P. M., Hegarty, A. M., Healey, J., Highfield, P. E., & TIDY, J. A. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s64087 · Cited by 57
Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer
Desai, K. G. H. (2017) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33943 · Cited by 53
Epithelial dysplasia of the oral cavity
Shirani, S., Kargahi, N., Razavi, S. M., & Homayoni, S. (1987) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(87)90047-8 · Cited by 51
EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis
Shih, C.-H., Chang, Y.-J., Huang, W.-C., Jang, T.-H., Kung, H.-J., Wang, W.-C., Yang, M.-H., Lin, M.-C., Huang, S.-F., Chou, S.-W., et al. (2017) · Oncogene · doi:10.1038/onc.2017.262 · Cited by 49
Leukoplakia, Oral Cavity Cancer Risk, and Cancer Survival in the U.S. Elderly
Yanik, E. L., Katki, H. A., Silverberg, M. J., Manos, M. M., Engels, E. A., & Chaturvedi, A. K. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0091 · Cited by 48
Identification of a combined biomarker for malignant transformation in oral submucous fibrosis
Bazarsad, S., Zhang, X., Kim, K., Illeperuma, R. P., Jayasinghe, R. D., Tilakaratne, W. M., & Kim, J. (2016) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12483 · Cited by 48
The role of hypoxia in oral cancer and potentially malignant disorders: a review
Kujan, O., Shearston, K., & Farah, C. S. (2016) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12488 · Cited by 48
Lee, J.-C., Chiang, K., Feng, T., Chen, Y.-J., Chuang, S.-T., Tsui, K., Chung, L., & Juang, H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091435 · Cited by 45
Shan, J., Sun, Z., Yang, J., Xu, J., Shi, W., Wu, Y., Yuan, F., & Li, H. (2018) · Oral Diseases · doi:10.1111/odi.12971 · Cited by 46
Ries, J., Agaimy, A., Wehrhan, F., Baran, C., Bolze, S., Danzer, E., Frey, S., Jantsch, J., Möst, T., Büttner-Herold, M. J., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9020194 · Cited by 46
Öhman, J. N., Mowjood, R., Larsson, L., Kovács, A., Magnusson, B., Kjeller, G., Jontell, M., & Hasséus, B. (2015) · PubMed · Cited by 44
Oral potentially malignant disorders: A scoping review of prognostic biomarkers
Mello, F. W., Melo, G., Guerra, E. N. S., Warnakulasuriya, S., Garnis, C., & Rivero, E. R. C. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.102986 · Cited by 43
Self-citationOverexpression of immunomodulatory mediators in oral precancerous lesions
Gonçalves, A. S., Mosconi, C., Jaeger, F., Wastowski, I. J., de Aguiar, M. C. F., Silva, T. A., Ribeiro‐Rotta, R. F., Costa, N. L., & Batista, A. C. (2017) · Human Immunology · doi:10.1016/j.humimm.2017.09.003 · Cited by 43
Evaluation and Management of Oral Potentially Malignant Disorders
Nadeau, C., & Kerr, A. R. (2017) · Dental Clinics of North America · doi:10.1016/j.cden.2017.08.001 · Cited by 40
White, red, and mixed lesions of oral mucosa: A clinicopathologic approach to diagnosis
Warnakulasuriya, S. (2019) · Periodontology 2000 · doi:10.1111/prd.12276 · Cited by 40
Self-citationThe efficacy of Ultra-High Frequency Ultrasonography in the diagnosis of intraoral lesions
Izzetti, R., Vitali, S., Aringhieri, G., Caramella, D., Nisi, M., Oranges, T., Dini, V., Graziani, F., & Gabriele, M. (2019) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2019.09.012 · Cited by 40
Prognostic significance of cytoplasmic S100A2 overexpression in oral cancer patients
Kumar, M., Srivastava, G., Kaur, J., Assi, J. S., Alyass, A., Leong, I., MacMillan, C., Witterick, I., Shukla, N. K., Thakar, A., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-014-0369-9 · Cited by 37
Shiga, K., Takahashi, K., Sato, I., Kato, K., Saijo, S., Moriya, S., Hosono, M., & Miyagi, T. (2015) · Cancer Science · doi:10.1111/cas.12810 · Cited by 35
MicroRNA-375 as a biomarker for malignant transformation in oral lesions
Harrandah, A. M., Fitzpatrick, S. G., Smith, M. H., Wang, D., Cohen, D. M., & Chan, E. K. L. (2016) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2016.07.022 · Cited by 35
Pires, F. R., Barreto, M., Nunes, J., Carneiro, N., Azevedo, A., & dos Santos, T. (2019) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.23197 · Cited by 33
The 4-NQO mouse model: An update on a well-established in vivo model of oral carcinogenesis
Bouaoud, J., Souza, G. D., Darido, C., Tortereau, A., Elkabets, M., Bertolus, C., & Saintigny, P. (2020) · Methods in cell biology · doi:10.1016/bs.mcb.2020.09.004 · Cited by 35
Liu, D., Xin, Z., Guo, S., Li, S., Cheng, J., & Jiang, H. (2020) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2020.12.043 · Cited by 33
de Moraes, J. K., Wagner, V. P., Fonseca, F. P., do Amaral‐Silva, G. K., de Farias, C. B., Pilar, E. F. S., Gregianin, L. J., Roesler, R., Vargas, P. A., & Martins, M. D. (2019) · Oral Diseases · doi:10.1111/odi.13190 · Cited by 31
Oral cancer prediction by noninvasive genetic screening
Poell, J. B., Wils, L. J., Brink, A., Dietrich, R., Krieg, C., Velleuer, E., Evren, I., Brouns, E. R. E. A., de Visscher, J. G. A. M., Bloemena, E., et al. (2022) · International Journal of Cancer · doi:10.1002/ijc.34277 · Cited by 29
Zhang, E., Liu, S., Xu, Z., Huang, S., Tan, X., Sun, C., & Lu, L. (2014) · Tumor Biology · doi:10.1007/s13277-014-2143-2 · Cited by 29
Fibrotic Effects of ArecolineN-Oxide in Oral Potentially Malignant Disorders
Kuo, T.-M., Luo, S., Chiang, S.-L., Yeh, K.-T., Hsu, H.-T., Wu, C.-T., Lu, C.-Y., Tsai, M.-H., Chang, J., & Ko, Y.-C. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b01351 · Cited by 29
Jiang, X., Wang, J., Chen, X.-J., Hong, Y., Wu, T., Chen, X.-B., Xia, J., & Cheng, B. (2016) · OncoTarget · doi:10.18632/oncotarget.7585 · Cited by 25
Sun, Y., Chen, K.-M., Kawasawa, Y. I., Salzberg, A. C., Cooper, T. K., Caruso, C., Aliaga, C. A., Zhu, J., Gowda, K., Amin, S., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186873 · Cited by 29
Frequent detection of high human papillomavirus DNA loads in oral potentially malignant disorders
Pierangeli, A., Cannella, F., Scagnolari, C., Gentile, M., Sciandra, I., Antonelli, G., Ciolfi, C., Russo, C., Palaia, G., Romeo, U., et al. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.09.011 · Cited by 28
Bui, D., Li, L., Yin, T., Wang, X., Gao, S., You, M., Singh, R., & Hu, M. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01475 · Cited by 27
Tong, F., Guo, J., Miao, Z., & Li, Z. (2020) · Cancer Biomarkers · doi:10.3233/cbm-191070 · Cited by 26
Ligier, K., Dejardin, O., Launay, L., Benoît, E., Babin, E., Bara, S., Lapôtre‐Ledoux, B., Launoy, G. D., & Guizard, A. (2016) · BMC Cancer · doi:10.1186/s12885-016-2531-7 · Cited by 25
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma
Costa, N. L., Gonçalves, A. S., Martins, A. F. L., Arantes, D. A. C., Silva, T. A., & Batista, A. C. (2015) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12380 · Cited by 25
Monteiro, L. S., do Amaral, B., Delgado, L., Garcês, F., Salazar, F., Pacheco, J. J., Lopes, C., & Warnakulasuriya, S. (2022) · Biomolecules · doi:10.3390/biom12050606 · Cited by 24
Self-citationOptical diagnosis of oral cavity lesions by label-free Raman spectroscopy
Matthies, L., Gebrekidan, M. T., Tegtmeyer, J. F., Oetter, N., Rohde, M., Vollkommer, T., Smeets, R., Wilczak, W., Stelzle, F., Gosau, M., et al. (2020) · Biomedical Optics Express · doi:10.1364/boe.409456 · Cited by 24
Oral Potentially Malignant Disorders (OPMD): What is the clinical utility of dysplasia grade?
Pritzker, K. P. H., Darling, M., Hwang, J., & Mock, D. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2021.1898949 · Cited by 27
Garg, A., Urs, A. B., Koner, B. C., Augustine, J., & Guru, S. A. (2023) · Head and Neck Pathology · doi:10.1007/s12105-023-01600-7 · Cited by 23
Benito-Ramal, E., Egido‐Moreno, S., González-Navarro, B., Jane-Salas, E., Roselló-Llabrés, X., & López-López, J. D. (2023) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.25889 · Cited by 23
Thomson, P. J., McCaul, J. A., Ridout, F., & Hutchison, I. L. (2015) · British Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.bjoms.2015.08.263 · Cited by 23
Zhang, E., LI, Z., Xu, Z., Duan, W., Sun, C., & Lu, L. (2015) · Oncology Reports · doi:10.3892/or.2015.4285 · Cited by 23
Chromosome instability in tumor resection margins of primary OSCC is a predictor of local recurrence
Pierssens, D. D. C. G., Borgemeester, M. C., van der Heijden, S. J. H., Peutz‐Kootstra, C. J., Rüland, A., Haesevoets, A. M., Kessler, P. A. W. H., Kremer, B., & Speel, E. M. (2017) · Oral Oncology · doi:10.1016/j.oraloncology.2016.12.029 · Cited by 23
Sharada, P., Swaminathan, U., Nagamalini, B., Kumar, K., Ashwini, B., & Lavanya, V. A. (2018) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/jomfp.jomfp_13_18 · Cited by 23
Bibliometric analysis of a century of research on oral erythroplakia and leukoplakia
Foy, J., Bertolus, C., Goudot, P., Deneuve, S., Blanc, E., Lasset, C., Pérol, D., & Saintigny, P. (2018) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12683 · Cited by 22
The Protective Role of Cranberries and Blueberries in Oral Cancer
Esquivel-Chirino, C., Bolaños-Carrillo, M. A., Ruiz, D. C., López-Macay, Á., Hernández‐Sánchez, F., Montes-Sánchez, D. G., Escuadra-Landeros, M., Gaitán-Cepeda, L. A., Maldonado-Frías, S., Ocampo, B. R. Y., et al. (2023) · Plants · doi:10.3390/plants12122330 · Cited by 22
Ji, X., Sun, T., Xie, S., Qian, H., Song, L., Wang, L., Liu, H., & Feng, Q. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00684-w · Cited by 21
Oral Carcinogenesis and Malignant Transformation
Farah, C. S., Shearston, K., Nguyen, A. P., & Kujan, O. (2019) · Head and neck cancer clinics · doi:10.1007/978-981-13-2931-9_3 · Cited by 21
Patel, N. R., Jain, L., Mahajan, A. M., Hiray, P. V., Shinde, S. S., & Patel, P. (2019) · Indian Journal of Otolaryngology and Head & Neck Surgery · doi:10.1007/s12070-019-01597-y · Cited by 21
Li, X., Liu, L., Zhang, J., Ma, M., Sun, L., Li, X., Zhang, H., Wang, J., Huang, Y., & Li, T. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-1965-x · Cited by 20
Mucoadhesive film containing α-mangostin shows potential role in oral cancer treatment
Tangsuksan, P., Chuerduangphui, J., Yupanqui, C. T., Srichana, T., Hitakomate, E., Pientong, C., Ekalaksananan, T., & Nittayananta, W. (2021) · BMC Oral Health · doi:10.1186/s12903-021-01845-0 · Cited by 20
Expression of cornulin in oral premalignant lesions
Santosh, N., McNamara, K. K., Beck, F. M., & Kalmar, J. R. (2019) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2019.02.003 · Cited by 20
Piemonte, E. D., Gilligan, G., Garola, F., Lazos, J. P., Panico, R., Normando, A. G. C., Santos‐Silva, A. R., & Warnakulasuriya, S. (2024) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2024.03.006 · Cited by 19
Self-citationSerum exosome-derived biomarkers for the early detection of oral squamous cell carcinoma
Guo, H., Jiang, W., Huang, S.-H., Huang, X., & Li, C. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04254-7 · Cited by 19
Toward the use of precision medicine for the treatment of head and neck squamous cell carcinoma
Gong, W., Xiao, Y., Wei, Z., Yao Zong, Y. U. A. N., Qiu, M., Sun, C., Zeng, X. Y., Liang, X., Feng, M., & Chen, Q. (2016) · Oncotarget · doi:10.18632/oncotarget.13798 · Cited by 19
Nikitakis, N. G., Rassidakis, G. Z., Tasoulas, J., Gkouveris, I., Kamperos, G., Daskalopoulos, A., & Sklavounou, A. (2018) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2018.03.006 · Cited by 19
Sundberg, J., Korytowska, M., Burgos, P. M., Blomgren, J., Blomstrand, L., Lara, S. D., Sand, L. P., Hirsch, J., Holmberg, E. C., Giglio, D., et al. (2019) · Anticancer Research · doi:10.21873/anticanres.13241 · Cited by 19
Chen, Q., Dan, H., Pan, W., Jiang, L., Zhou, Y. J., Luo, X., & Zeng, X. Y. (2021) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2021.03.009 · Cited by 18
Exploring the microbiome of oral epithelial dysplasia as a predictor of malignant progression
Wright, R., Pewarchuk, M. E., Marshall, E. A., Murrary, B., Rosin, M. P., Laronde, D. M., Zhang, L., Lam, W. L., Langille, M. G. I., & Rock, L. D. (2023) · BMC Oral Health · doi:10.1186/s12903-023-02911-5 · Cited by 18
Fugle, C. W., Zhang, Y., Hong, F., Sun, S., Westwater, C., Rachidi, S., Yu, H. H., Garret-Mayer, E., Kirkwood, K. L., Liu, B., et al. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1226719 · Cited by 18
DNA aneuploidy relationship with patient age and tobacco smoke in OPMDs/OSCCs
Castagnola, P., GANDOLFO, S., Malacarne, D., Aiello, C., Marino, R., Zoppoli, G. M., Ballestrero, A., Giaretti, W., & Pentenero, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184425 · Cited by 18
Long-term follow-up of oral epithelial dysplasia: A hospital based cross-sectional study
Jaber, M. A., & Elameen, E. M. (2020) · Journal of Dental Sciences · doi:10.1016/j.jds.2020.04.003 · Cited by 18
Lombardi, N., Arduino, P. G., Lampiano, M., Gambino, A., Broccoletti, R., Varoni, E. M., & Lodi, G. (2024) · Oral Diseases · doi:10.1111/odi.15058 · Cited by 17
Liu, Y., Tan, Y., Sun, W., Ju, W., Fu, Y., Wang, L., Li, J., Zhang, C., Zhang, Z., & Zhong, L. (2018) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201700180 · Cited by 17
López‐López, J., Cepeda, C. J. O., & Salas, E. J. (2015) · Medicina Clínica · doi:10.1016/j.medcli.2014.11.014 · Cited by 17
Oral cancer prevention worldwide: Challenges and perspectives.
Foy, J.-P., Bertolus, C., & Saintigny, P. (2019) · Oral Oncology · doi:10.1016/j.oraloncology.2018.11.008 · Cited by 13
Molecular markers associated with potentially malignant oral lesions (Review)
Hrițcu, O. M. C., Botez, A. E., Temelie-Olinici, D., Onofrei, P., Stoica, L., Grecu, V. B., Toader, M. P., Solovăstru, L. G., & Cotrutz, E. C. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10266 · Cited by 16
Expression of p53, p63, podoplanin and Ki-67 in recurring versus non-recurring oral leukoplakia
Sundberg, J., Pandey, S., Giglio, D., Holmberg, E. C., Kjeller, G., Kovács, A., Sand, L. P., Şengüven, B., Öhman, J. N., Sapkota, D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-99326-5 · Cited by 16
Tan, M. T., Wu, J. G., Callejas‐Valera, J. L., Schwarz, R. A., Gillenwater, A. M., Richards-Kortum, R. R., & Vigneswaran, N. (2020) · International Journal of Experimental Pathology · doi:10.1111/iep.12347 · Cited by 16
Oral potentially malignant disorders
Soares, A. B., Perschbacher, K., & Perez‐Ordoñez, B. (2018) · Diagnostic histopathology · doi:10.1016/j.mpdhp.2018.03.005 · Cited by 15
Ge, S., Liu, L., Zhou, Q., Lou, B., Zhou, Z., Lou, J., & Fan, Y. (2020) · PeerJ · doi:10.7717/peerj.8644 · Cited by 15
Sundberg, J., Öhman, J. N., Korytowska, M., Wallström, M., Kjeller, G., Andersson, M., Horal, P., Lindh, M., Giglio, D., Kovács, A., et al. (2020) · Oral Diseases · doi:10.1111/odi.13510 · Cited by 15
Wagner, V. P., Cardoso, P. R., dos Santos, J. N., Meurer, L., Vargas, P. A., Fonseca, F. P., Carrard, V. C., & Martins, M. D. (2016) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000355 · Cited by 15
Current aspects and future strategies in oral cancer research: A review
Rao, R. S., Patil, S. V., Ghosh, S., & Kumari, K. (2015) · Journal of Medicine Radiology Pathology & Surgery · doi:10.15713/ins.jmrps.15 · Cited by 15
Miyahara, L. A. N., Pontes, F. S. C., Burbano, R. M. R., Neto, N. C., Guimarães, D. M., Fonseca, F. P., & Pontes, H. A. R. (2017) · Histopathology · doi:10.1111/his.13381 · Cited by 15
Ribeiro, I. P., Marques, F., Barroso, L., Rodrigues, J. M., Caramelo, F. J., Melo, J. B., & Carreira, I. M. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7428 · Cited by 14
Chung, C., Hung, C.-C., Lee, C., Lee, C., Lee, K., Chen, M., Yeh, K., & Ko, Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210901 · Cited by 14
Takemoto, M., Garcez, A. S., & Sperandio, M. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.111592 · Cited by 14
Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP
Kang, Y., Chen, J., Li, X., Luo, M., Chen, H., Cui, B., Wang, L., Lv, D., Feng, Y., & Zhang, P. (2021) · Cancer Biomarkers · doi:10.3233/cbm-203105 · Cited by 14
Metadata
- Authors
- Dionne, K. R., Warnakulasuriya, S., Binti Zain, R., & Cheong, S. C.
- Affiliations
- University of Malaya (MY)
- King's College London (GB)
- Faculty of Dentistry Oral Cancer Research and Co‐ordinating Centre (OCRCC), University of Malaya Kuala Lumpur Malaysia
- Corresponding author
- Cheong, Sok Ching
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2014-02-11
- Volume
- 136
- Issue
- 3
- Pages
- 503-515
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2154220394
- Cited by
- 248
- References
- 160
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 17 · 2023: 24 · 2022: 32 · 2021: 29 · 2020: 30 · 2019: 20 · 2018: 17 · 2017: 19 · 2016: 21 · 2015: 17 · 2014: 6
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Health Sciences › Dentistry › General Dentistry › HIV/AIDS oral health manifestations
- Keywords
- oral potentially malignant disorders, oral squamous cell carcinoma, leukoplakia, erythroplakia, oral submucous fibrosis, chemoprevention, oral cancer screening, early diagnosis, oral carcinogenesis, oral epithelium, in vitro disease model
- MeSH terms
- Aged, Carcinoma, Squamous Cell, DNA, Humans, Leukoplakia, Oral, Male, Middle Aged, Mouth Neoplasms, Ploidies, Loss of Heterozygosity, Cyclin D1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
