The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Neutrophils recruit regulatory T‐cells into tumors via secretion of CCL17—A new mechanism of impaired antitumor immunity
Abstract
The mechanisms by which tumor‐associated neutrophils (TANs) affect tumor growth are to a large extent unknown. Regulatory T‐cells (T‐regs) are functionally immune‐suppressive subsets of T‐cells. Depletion or inhibition of T‐regs can enhance antitumor immunity. We demonstrated both by RT‐PCR and by ELISA that murine TANs secrete significant amounts of the T‐regs chemoattractant, CCL17, much more than circulating or splenic neutrophils, and at a level progressively increasing during tumor development. Migration assays, both in vitro and in vivo, showed recruitment of T‐regs by TANs, which was inhibited with anti‐CCL17 monoclonal antibodies. Systemic neutrophil depletion in tumor‐bearing mice using anti‐Ly6G monoclonal antibodies reduced the migration of T‐regs into the tumors. We further showed, using flow cytometry, that CCL17 secretion by TANs is not limited to mouse models of cancer but is also relevant to human TANs. Our results suggest a new indirect mechanism by which TANs may inhibit antitumor immune activity, thus promoting tumor growth. We further describe, for the first time, a clear link between TANs and T‐regs acting together to impair antitumor immunity.
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Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
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Self-citationNeutrophils in the activation and regulation of innate and adaptive immunity
Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature Reviews Immunology · doi:10.1038/nri3024 · Cited by 3,027
Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice
Daley, J. M., Thomay, A. A., Connolly, M. D., Reichner, J. S., & Albina, J. E. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0407247 · Cited by 1,046
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T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis
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Evidence for a cross-talk between human neutrophils and Th17 cells
Pelletier, M., Maggi, L., Micheletti, A., Lazzeri, E., Tamassia, N., Costantini, C., Cosmi, L., Lunardi, C., Annunziato, F., Romagnani, S., et al. (2010) · Blood · doi:10.1182/blood-2009-04-216085 · Cited by 782
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The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
Plaks, V., Kong, N., & Werb, Z. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.02.015 · Cited by 1,557
Neutrophil-derived cytokines: facts beyond expression
Tecchio, C., Micheletti, A., & Cassatella, M. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00508 · Cited by 699
Social networking of human neutrophils within the immune system
Scapini, P., & Cassatella, M. A. (2014) · Blood · doi:10.1182/blood-2014-03-453217 · Cited by 406
Neutrophils at the crossroads of innate and adaptive immunity
Rosales, C. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mir0220-574rr · Cited by 372
Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy
Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2019 · Cited by 310
Metadata
- Authors
- Mishalian, I., Bayuh, R., Eruslanov, E., Michaeli, J., Levy, L., Zolotarov, L., Singhal, S., Albelda, S. M., Granot, Z., & Fridlender, Z. G.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2014-02-27
- Volume
- 135
- Issue
- 5
- Pages
- 1178-1186
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1595547013
- Cited by
- 253
- References
- 38
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mishalian, I., Bayuh, R., Eruslanov, E., Michaeli, J., Levy, L., Zolotarov, L., Singhal, S., Albelda, S. M., Granot, Z., & Fridlender, Z. G. (2014). Neutrophils recruit regulatory T‐cells into tumors via secretion of CCL17—A new mechanism of impaired antitumor immunity. International Journal of Cancer. https://doi.org/10.1002/ijc.28770
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