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Cited by 1,557Cancer Cells and MetastasisMesenchymal stem cell researchHematopoietic Stem Cell Transplantation

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

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Plaks, Vicki, Kong, Niwen, Werb, Zena·2015·Cell Stem Cell
DOI 10.1016/j.stem.2015.02.015PMC PMC4355577
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Abstract

Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal, clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in niches, which are anatomically distinct regions within the tumor microenvironment. These niches maintain the principle properties of CSCs, preserve their phenotypic plasticity, protect them from the immune system, and facilitate their metastatic potential. In this perspective, we focus on the CSC niche and discuss its contribution to tumor initiation and progression. Since CSCs survive many commonly employed cancer therapies, we examine the prospects of targeting the niche components as preferable therapeutic targets.

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  • CAFs secrete MMPs including MMP-2, MMP-3, and MMP-9, or activate Yes-associated protein to promote ECM degradation and remodeling, EMT, and CSC stemness.

    “CAFs reportedly secrete matrix metalloproteinases (MMPs), including MMP-2, MMP-3, and MMP-9, or activate Yes-associated protein to promote ECM degradation and remodeling, EMT, and CSC stemness.283–287”

    From Drug repurposing for cancer therapy (2024) · cites this paper as [286]

    The ‘Extracellular matrix-cell interactions and cell-cell contact’ section (page unavailable) says CAFs produce MMP2, MMP3, and MMP9 for ECM remodeling, promoting EMT and CSC-related marker expression; it also says MMPs degrade ECM components. The cited copy does not support the alternative claim that CAFs activate Yes-associated protein for these effects. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Plaks, V., Kong, N., & Werb, Z.
Affiliations
University of California, San Francisco (US)
Corresponding author
Werb, Zena
ORCID
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2015-03
Volume
16
Issue
3
Pages
225-238
ISSN
  • 1875-9777 (ISSN-L)
  • 1934-5909
DOI
10.1016/j.stem.2015.02.015
PMC
PMC4355577
OpenAlex
W2071123870
Cited by
1,557
References
15
Citations by year
2026: 47 · 2025: 102 · 2024: 140 · 2023: 152 · 2022: 202 · 2021: 184 · 2020: 185 · 2019: 168 · 2018: 138 · 2017: 117 · 2016: 84 · 2015: 37
FWCI
13.48
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell stem cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • China Scholarship Council
  • National Cancer Institute (R01CA180039, CA 057621, R01CA057621, CA180039)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords
cancer stem cells, tumor microenvironment, stem cell niche, stemness, self-renewal, tumor initiation, tumor progression, metastasis, immune evasion, phenotypic plasticity
MeSH terms
Animals, Humans, Neoplasm Metastasis, Neoplasms, Neoplastic Stem Cells, Stem Cell Niche, Tumor Microenvironment

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