Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,355

The DOI matches its Crossref record.

Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity

Herberman, Ronald B., Nunn, Myrthel E., Lavrin, David H.·1975·International Journal of Cancer
DOI 10.1002/ijc.2910160204
Open this paper in CoChat — free account

Abstract

Lymphoid cells from many normal mice of a variety of inbred strains were found to have reactivity, in a 51 Cr release cytotoxicity assay, against several syngeneic and allogeneic tumors. Very high reactivity was seen with effector cells from athymic nude mice, which was consistent with other evidence that the reactivity was not T‐cell dependent. Target cells susceptible to lysis included tumors induced by oncogenic type‐C viruses but also tumors induced by other means and expressing endogenous type‐C viruses. The levels of natural reactivity were influenced by age, with highest cytotoxicity produced by cells from 5‐ to 8‐week‐old mice. Lymph‐node cells, spleen cells, peritoneal exudate cells and peripheral blood lymphocytes all had cytotoxic reactivity. The specificity of the reactions was analyzed in detail by an inhibition assay. Evidence was obtained for natural reactivity against several different antigens, each apparently associated with expression of murine endogenous type‐C viruses.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/ijc.2910160204

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 33

  1. 10.1073/pnas.71.5.1957 · DOI
  2. Aoki T., 1966, Occurrence of natural antibody to the G (Gross) leukemia antigen in mice, Cancer Res., 26, 1415
  3. Blair P. B., 1974, Immunologic evidence for horizontal transmission of MTV, J. Immunol., 113, 1446, 10.4049/jimmunol.113.5.1446 · doi:10.4049/jimmunol.113.5.1446
  4. Blair P. B., 1974, In vitro detection of immune response to MTV‐induced mammary tumors: Activity of spleen cells from both MTV‐free and MTV‐infected mice, J. Immunol., 112, 693, 10.4049/jimmunol.112.2.693 · doi:10.4049/jimmunol.112.2.693
  5. Canty T. G., 1970, Quantitative in vitro assay of cytotoxic cellular immunity, J. nat. Cancer Inst., 45, 761
  6. Greenberg A. H., 1974, Spontaneously arising cytotoxicity to the P‐815‐Y mastocytoma in NZB mice, Clin. exp. Immunol., 16, 99
  7. Hanna M. G., 1972, Autogenous immunity to endogenous RNA tumor virus antigens in mice with low natural incidence of lymphoma, Cancer Res., 32, 2226
  8. 10.1084/jem.136.1.94 · doi:10.1084/jem.136.1.94
  9. 10.1093/jnci/53.4.1103 · doi:10.1093/jnci/53.4.1103
  10. 10.1002/ijc.2910160205 · DOI · Paper page
  11. 10.1093/jnci/51.5.1509 · doi:10.1093/jnci/51.5.1509
  12. Herberman R. B., 1974, Progress in immunology, II, 285
  13. 10.1084/jem.138.1.194 · doi:10.1084/jem.138.1.194
  14. Kaplan M. H., 1967, Cross‐reacting antigens and neoantigens, 48
  15. 10.1002/eji.1830050208 · DOI · Paper page
  16. 10.1002/eji.1830050209 · DOI · Paper page
  17. 10.1002/ijc.2910150608 · DOI · Paper page
  18. 10.1093/jnci/51.5.1497 · doi:10.1093/jnci/51.5.1497
  19. McCoy J. L., 1973, 51Chromium‐release assay for cell‐mediated cytotoxicity of human leukemia and lymphoid tissue‐culture cells, Nat. Cancer Inst. Monogr., 37, 59
  20. 10.1126/science.185.4154.869 · doi:10.1126/science.185.4154.869
  21. Nunn M., 1973, Natural cytotoxic reactivity of rat lymphocytes against syngeneic Gross leukemia, Proc. Amer. Ass. Cancer Res., 14, 87
  22. Oldham R. K., 1973, Evaluation of a cell‐mediated cytotoxicity assay utilizing 125Iododeoxyuridine‐labelled tissue‐culture target cells, Nat. Cancer Inst., Monogr., 37, 49
  23. Oldham R. K. Weiner R. S. Mathe G. Breard J. Simmler M. C. Carde P. andHerberman R. B. Cell‐mediated immune responsiveness of patients with acute lymphocytic leukemia in remission.J. nat. Cancer Inst. in press (1975). · doi:10.1002/ijc.2910170308
  24. 10.1073/pnas.69.1.134 · DOI
  25. Ortiz de Landazuri M., 1972, Immune response to Gross virus‐induced lymphoma. III. Characteristics of the cellular immune response, J. nat. Cancer Inst., 49, 147
  26. 10.1002/ijc.2910090323 · DOI
  27. 10.1093/jnci/52.2.345 · DOI · Paper page
  28. 10.1084/jem.138.3.593 · doi:10.1084/jem.138.3.593
  29. Sendo F. Aoki T. Boyse E. A. andBuafo C. K. Natural occurrence of lymphocytes showing cytotoxic activity to BALB/c radiation‐induced leukemia RL♂l cells.J. nat. Cancer Inst. in press (1975). · DOI
  30. Springer G. F., 1967, Cross‐reacting antigens and neoantigens, 29
  31. Stanton M. F., 1968, Some biologic, immunogenic and morphologic effects in mice after infection with a murine sarcoma virus. II. Morphologic studies, J. nat. Cancer Inst., 40, 1113
  32. 10.1038/253142a0 · doi:10.1038/253142a0
  33. Takasugi M., 1974, Studies on specificity of cell‐mediated immunity to human tumors, J. nat. Cancer Inst., 53, 1527

Cited by

See all 1,355

Metadata

Authors
Herberman, R. B., Nunn, M. E., & Lavrin, D. H.
Venue
International Journal of Cancer
Publisher
Wiley
Published
1975-08-15
Volume
16
Issue
2
Pages
216-229
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
DOI
10.1002/ijc.2910160204
OpenAlex
W2147787458
Cited by
1,355
References
0
FWCI
13.97
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 11295 d)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity. https://app.cochat.ai/papers/10.1002/ijc.2910160204
The paper
Herberman, R. B., Nunn, M. E., & Lavrin, D. H. (1975). Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity. International Journal of Cancer. https://doi.org/10.1002/ijc.2910160204

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.