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Cited by 1,150Immune Cell Function and InteractionImmune cells in cancerReproductive System and Pregnancy

Natural Killer Cells: Development, Maturation, and Clinical Utilization

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Abel, Alex M., Yang, Chao, Thakar, Monica S., Malarkannan, Subramaniam·2018·Frontiers in Immunology
DOI 10.3389/fimmu.2018.01869PMC PMC6099181
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Abstract

Natural killer cells are the predominant innate lymphocyte subsets that mediate anti-tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells do not express polymorphic clonotypic receptors and utilize inhibitory receptors (KIR and Ly49) to develop, mature, and recognize ‘self’ from ‘non-self’. The essential roles of common gamma cytokines such as IL-2, IL-7, and IL-15 in the commitment and development of NK cells are well-established. However, the critical functions of proinflammatory cytokines IL-12, IL-18, IL-27, and IL-35 in the transcriptional-priming of NK cells are only starting to emerge. Recent studies have highlighted multiple shared characteristics between NK cells the adaptive immune lymphocytes. NK cells utilize unique signaling pathways that offer exclusive ways to genetically manipulate to improve their effector functions. Here, we summarize the recent advances made in the understanding of how NK cells develop, mature, and their potential translational use in the clinic.

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  • NK cells do not produce IL-1 and IL-6, which are key cytokines involved in the development of CRS.

    “Importantly, NK cells do not produce IL-1 and IL-6, which are key cytokines involved in the development of CRS [266, 267].”

    From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [266]

    The “NK Cell-Mediated Pro-Inflammatory Cytokine Production” section says NK cells primarily produce IFN-γ, TNF, and GM-CSF in the conditions described, but also says their cytokine production varies with the inflammatory environment. Neither that section nor the passages found by searching for IL-1, IL-6, and cytokine release syndrome (CRS) state that NK cells do not produce IL-1 or IL-6, or that those cytokines are key to CRS. (LLM, conf=0.74)

    Experimental — accuracy not yet measured

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Authors
Abel, A. M., Yang, C., Thakar, M. S., & Malarkannan, S.
Affiliations
Medical College of Wisconsin (US)
Corresponding author
Malarkannan, Subramaniam
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2018-08-13
Volume
9
Pages
1869-1869
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2018.01869
PMC
PMC6099181
OpenAlex
W2885605094
Cited by
1,150
References
9
Citations by year
2026: 96 · 2025: 144 · 2024: 171 · 2023: 186 · 2022: 192 · 2021: 183 · 2020: 119 · 2019: 54 · 2018: 4 · 2017: 1
FWCI
9.22
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (R01 AI102893)
  • National Cancer Institute (R01 CA179363)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
natural killer cells, NK cell development, NK cell maturation, inhibitory receptors, killer cell immunoglobulin-like receptors, Ly49, IL-15, IL-7, interleukin-2, inflammatory cytokines, IL-12, IL-18, IL-27, IL-35, innate lymphoid cells, NK cell effector function, NK cell engineering, cancer immunotherapy, antiviral immunity
MeSH terms
Animals, Cell Differentiation, Humans, Immunity, Innate, Immunologic Surveillance, Immunotherapy, Killer Cells, Natural, Neoplasms, Virus Diseases, Signal Transduction, Cytokines, Interleukin Receptor Common gamma Subunit, Receptors, KIR, NK Cell Lectin-Like Receptor Subfamily A, Translational Research, Biomedical

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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