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Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)
Abstract
A human hematopoietic cell line (U‐937) with exceptional characteristics was derived from a patient with generalized histiocytic lymphoma. The morphology of the cell line was identical to that of the tumor cells in the pleural effusion from which the line was derived. Since Epstein‐Barr virus (EBV) carrying diploid lymphoblastoid cell lines unrelated to the tumor population often become established in vitro from non‐Burkitt lymphoma explants, several parameters were studied to discriminate the U‐937 from such lines: morphology in vitro, growth characteristics, cytochemistry, surface receptor pattern, Ig production, lysozyme production, β 2‐micro‐globulin production, presence of EBV genome and karyotype. In all these respects U‐937 differed from prototype lymphoblastoid cell lines. The histiocytic origin of the cell line was shown by its capacity for lysozyme production and the strong esterase activity (naphtol AS‐D acetate esterase inhibited by NaF) of the cells. It is therefore concluded that the U‐937 is a neoplastic, histiocytic cell line.
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Cited by
Chen, P.-L., Scully, P., Shew, J.-Y., Wang, J. Y. J., & Lee, W.-H. (1989) · Cell · doi:10.1016/0092-8674(89)90517-5 · Cited by 952
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Specht, H., Emmott, E., Petelski, A. A., Huffman, R. G., Perlman, D. H., Serra, M., Kharchenko, P., Koller, A., & Slavov, N. (2021) · Genome Biology · doi:10.1186/s13059-021-02267-5 · Cited by 493
AML1–ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia
Pabst, T., Mueller, B. U., Harakawa, N., Schoch, C., Haferlach, T., Behre, G., Hiddemann, W., Zhang, D.-E., & Tenen, D. G. (2001) · Nature Medicine · doi:10.1038/86515 · Cited by 463
Nguyen, H. Q., Hoffman-Liebermann, B., & Liebermann, D. A. (1993) · Cell · doi:10.1016/0092-8674(93)90660-i · Cited by 367
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Le, C. P., Nowell, C. J., Kim-Fuchs, C., Botteri, E., Hiller, J. G., Ismail, H., Pimentel, M. A., Chai, M. G., Karnezis, T., Rotmensz, N., et al. (2016) · Nature Communications · doi:10.1038/ncomms10634 · Cited by 354
Metadata
- Authors
- Sundström, C., & Nilsson, K.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 1976-05-15
- Volume
- 17
- Issue
- 5
- Pages
- 565-577
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2133764756
- Cited by
- 2,407
- References
- 0
- FWCI
- 15.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sundström, C., & Nilsson, K. (1976). Establishment and characterization of a human histiocytic lymphoma cell line (U‐937). International Journal of Cancer. https://doi.org/10.1002/ijc.2910170504
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
