The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Phenotypic changes of human neuroblastoma cells in culture induced by 12‐O‐tetradecanoyl‐phorbol‐13‐acetate
Abstract
SK‐N‐SH and SH‐SYSY human neuroblastoma cells treated by 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA) express morphological and biochemical changes, which indicate that differentiation towards more mature cells has occurred. The most prominent morphological changes were the development in 40–60% of the cells of cell‐surface projections longer than 50 μm and cytoplasmic neurosecretory granules demonstrated by electron microscopy. At the biochemical level, TPA induced a two‐fold increase in the relative activity of neuron‐specific enolase and 30‐ to 40‐fold increase in noradrenaline and adrenaline concentrations. A decrease in proliferation rate of TPA‐treated cells was observed. The biological effects of TPA were slightly potentiated by nerve growth factor.
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Cited by
Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology
Kovalevich, J., & Langford, D. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-640-5_2 · Cited by 1,005
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López-Carballo, G., Moreno, L., Masiá, S., Pérez, P., & Barettino, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201869200 · Cited by 301
Metadata
- Authors
- Påhlman, S., Odelstad, L., Larsson, E., Grotte, G., & Nilsson, K.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 1981-11-15
- Volume
- 28
- Issue
- 5
- Pages
- 583-589
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1992604829
- Cited by
- 259
- References
- 19
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Phenotypic changes of human neuroblastoma cells in culture induced by 12‐O‐tetradecanoyl‐phorbol‐13‐acetate. https://app.cochat.ai/papers/10.1002/ijc.2910280509
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- Påhlman, S., Odelstad, L., Larsson, E., Grotte, G., & Nilsson, K. (1981). Phenotypic changes of human neuroblastoma cells in culture induced by 12‐O‐tetradecanoyl‐phorbol‐13‐acetate. International Journal of Cancer. https://doi.org/10.1002/ijc.2910280509
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
