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Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents.
Open accessAbstract
Human promyelocytic leukemia cells (HL-60) were induced to differentiate into mature cells by the tumor-promoting agent phorbol-12-myristate-13-acetate and other related phorbol diesters. Differentiation was determined by an increase in the percent of myelocytes, metamyelocytes, and other mature myeloid cells as well as by an increase in the percent of phagocytizing cells. Induction of differentiation could be determined after 2 days of treatment with phorbol-12-myristate-13-acetate at a dose as low as 6 X 10(11) M. A correlation was found between reported tumor-promoting activity of a series of phorbol esters and their ability to induce myeloid differentiation and to inhibit cell growth. It is suggested that tumor-promoting agents like chemicals that induce terminal differentiation in these cells, at extremely low concentrations, may be used as a tool in the study of the control of cell growth, cell differentiation, and malignancy in human leukemic cells.
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Cited by
Biology of Natural Killer Cells
Trinchieri, G. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60664-1 · Cited by 2,902
Expression of c-jun during macrophage differentiation of HL-60 cells
Gaynor, R., Simon, K., & Koeffler, P. (1991) · Blood · doi:10.1182/blood.v77.12.2618.2618 · Cited by 59
Modulation of LDL receptor mRNA stability by phorbol esters in human liver cell culture models
Wilson, G. M., Roberts, E. A., & Deeley, R. G. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37252-7 · Cited by 34
Unlap, T., Franklin, C. C., Wagner, F., & Kraft, A. S. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.4.897 · Cited by 32
Metadata
- Authors
- Huberman, E., & Callaham, M. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-03
- Volume
- 76
- Issue
- 3
- Pages
- 1293-1297
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2058901530
- Cited by
- 500
- References
- 0
- FWCI
- 16.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Huberman, E., & Callaham, M. F. (1979). Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.3.1293
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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