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Cited by 124Thyroid Cancer Diagnosis and TreatmentThyroid Disorders and TreatmentsEffects of Radiation Exposure

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Cancer mortality after iodine‐131 therapy for hyperthyroidism

Hall, Per, Berg, Gertrud, Bjelkengren, Göran, Boice, John D., Ericsson, Ulla‐Britt, Hallquist, Arne, Lidberg, Monika, Lundell, GÖRan, Tennvall, Jan, Wiklund, Kerstin, Holm, Lars‐Erik·1992·International Journal of Cancer
DOI 10.1002/ijc.2910500611
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Abstract

Cancer mortality was studied in 10,552 Swedish hyperthyroid patients treated with 131 l between 1950 and 1975. The patients were matched with the Swedish Cause‐of‐Death Register and the cases of 977 patients who died from cancer or leukemia were studied. The patients had been followed up for an average of 15 years (range 0 to 35 years), and the overall standardized mortality ratio (SMR) was 1.09 [95% confidence interval (CI) = 1.03 to 1.16], with a higher risk for women. The highest mortality was seen during the first year after exposure (SMR = 1.15) and decreased for the following 9 years (SMR = 1.04). The risk of dying from a cancer in the digestive tract and respiratory organs was significantly elevated more than 10 years after exposure, as was the overall cancer mortality (SMR = 1.14). No increased risk was seen for leukemia, bladder cancer or breast cancer. Younger patients and those receiving 131 I at higher activity had higher SMRs than older patients and those receiving lower activity. Patients with toxic nodular goiter had higher risk than those with Graves' disease. The lack of increasing mortality over time and with increasing activity of 131 I administered argues against a carcinogenic effect of 131 I. However, in the case of cancers of the stomach, the 131 I exposure could have contributed to the excess mortality from these cancers.

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Research works printed but not linked: 4

  1. Holm L.‐E., 1984, Radiation carcinogenesis: epidemiology and biological significance, 263
  2. 1948, ICD‐6, Manual of the international classification of diseases, injuries and causes of death, 1945 revision
  3. 1957, ICD‐7, International classification of diseases, injuries and causes of death, 1955 revision
  4. 1967, ICD‐8, International classification of diseases, injuries and causes of death, 1965 revision

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Metadata

Authors
Hall, P., Berg, G., Bjelkengren, G., Boice, J. D., Ericsson, U., Hallquist, A., Lidberg, M., Lundell, G., Tennvall, J., Wiklund, K., & Holm, L.
Affiliations
  • Karolinska University Hospital (SE)
  • Sahlgrenska University Hospital (SE)
  • Skåne University Hospital (SE)
  • National Cancer Institute (US)
  • University Hospital of Umeå (SE)
  • Stockholm South General Hospital (SE)
Corresponding author
Hall, Per
ORCID
Venue
International Journal of Cancer
Publisher
Wiley
Published
1992-04
Volume
50
Issue
6
Pages
886-890
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
DOI
10.1002/ijc.2910500611
OpenAlex
W1968700299
Cited by
124
References
26
Citations by year
2025: 3 · 2024: 3 · 2022: 2 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
FWCI
1.13
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5220 d)
Locations
  • International Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01cp051034-001)
  • National Cancer Institute (N01-CP-51034)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords
iodine-131 therapy, hyperthyroidism, cancer mortality, radiation-induced cancer, carcinogenicity, standardized mortality ratio, toxic nodular goiter, Graves' disease, gastric cancer, leukemia, respiratory cancer, digestive tract cancer
MeSH terms
Age Factors, Female, Humans, Hyperthyroidism, Iodine Radioisotopes, Leukemia, Leukemia, Radiation-Induced, Male, Middle Aged, Neoplasms, Neoplasms, Radiation-Induced, Registries, Retrospective Studies, Sweden, Time Factors

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