CoChat
Sign Up
Cited by 124Thyroid Cancer Diagnosis and TreatmentThyroid Disorders and TreatmentsEffects of Radiation Exposure

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Cancer mortality after iodine‐131 therapy for hyperthyroidism

Hall, Per, Berg, Gertrud, Bjelkengren, Göran, Boice, John D., Ericsson, Ulla‐Britt, Hallquist, Arne, Lidberg, Monika, Lundell, GÖRan, Tennvall, Jan, Wiklund, Kerstin, Holm, Lars‐Erik·1992·International Journal of Cancer
DOI 10.1002/ijc.2910500611
Open this paper in CoChat — free account

Abstract

Cancer mortality was studied in 10,552 Swedish hyperthyroid patients treated with 131 l between 1950 and 1975. The patients were matched with the Swedish Cause‐of‐Death Register and the cases of 977 patients who died from cancer or leukemia were studied. The patients had been followed up for an average of 15 years (range 0 to 35 years), and the overall standardized mortality ratio (SMR) was 1.09 [95% confidence interval (CI) = 1.03 to 1.16], with a higher risk for women. The highest mortality was seen during the first year after exposure (SMR = 1.15) and decreased for the following 9 years (SMR = 1.04). The risk of dying from a cancer in the digestive tract and respiratory organs was significantly elevated more than 10 years after exposure, as was the overall cancer mortality (SMR = 1.14). No increased risk was seen for leukemia, bladder cancer or breast cancer. Younger patients and those receiving 131 I at higher activity had higher SMRs than older patients and those receiving lower activity. Patients with toxic nodular goiter had higher risk than those with Graves' disease. The lack of increasing mortality over time and with increasing activity of 131 I administered argues against a carcinogenic effect of 131 I. However, in the case of cancers of the stomach, the 131 I exposure could have contributed to the excess mortality from these cancers.

Overview

Integrity signals

Registry

Crossref · 10.1002/ijc.2910500611

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 26 references

Research works printed but not linked: 4

  1. Holm L.‐E., 1984, Radiation carcinogenesis: epidemiology and biological significance, 263
  2. 1948, ICD‐6, Manual of the international classification of diseases, injuries and causes of death, 1945 revision
  3. 1957, ICD‐7, International classification of diseases, injuries and causes of death, 1955 revision
  4. 1967, ICD‐8, International classification of diseases, injuries and causes of death, 1965 revision

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Hall, P., Berg, G., Bjelkengren, G., Boice, J. D., Ericsson, U., Hallquist, A., Lidberg, M., Lundell, G., Tennvall, J., Wiklund, K., & Holm, L.
Affiliations
  • Karolinska University Hospital (SE)
  • Sahlgrenska University Hospital (SE)
  • Skåne University Hospital (SE)
  • National Cancer Institute (US)
  • University Hospital of Umeå (SE)
  • Stockholm South General Hospital (SE)
Corresponding author
Hall, Per
ORCID
Venue
International Journal of Cancer
Publisher
Wiley
Published
1992-04
Volume
50
Issue
6
Pages
886-890
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
DOI
10.1002/ijc.2910500611
OpenAlex
W1968700299
Cited by
124
References
26
Citations by year
2025: 3 · 2024: 3 · 2022: 2 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
FWCI
1.13
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5220 d)
Locations
  • International Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01cp051034-001)
  • National Cancer Institute (N01-CP-51034)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords
iodine-131 therapy, hyperthyroidism, cancer mortality, radiation-induced cancer, carcinogenicity, standardized mortality ratio, toxic nodular goiter, Graves' disease, gastric cancer, leukemia, respiratory cancer, digestive tract cancer
MeSH terms
Age Factors, Female, Humans, Hyperthyroidism, Iodine Radioisotopes, Leukemia, Leukemia, Radiation-Induced, Male, Middle Aged, Neoplasms, Neoplasms, Radiation-Induced, Registries, Retrospective Studies, Sweden, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review