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Mesothelioma in rats following intrapleural injection of chrysotile and phosphorylated chrysotile (chrysophosphate)
Abstract
Pathological effects of asbestos are probably dependent on the size and surface properties of the fibers. Surface‐modified chrysotile fibers were injected into the pleural cavity of rats to investigate the potency of the fiber to induce mesothelioma. Chrysotile fibers were modified by a phosphorylation process, resulting in the presence of phosphorus at the fiber surface. Phosphorylated samples were characterized by enhanced durability and reduced affinity for biological macromolecules. Five samples were tested: I untreated and 4 phosphorylated. ChrP1, ChrP2 and ChrP3 corresponded to phosphorylated samples obtained by first, second and third passages through an Alpine classifier; Pm was defibrillated ChrP1. The number of fibers per microgram and the size distribution were determined by transmission electron microscopy and classified in 4 size groups. Groups of 35 rats were inoculated with 20 mg of fibers suspended in 0.9% NaCl solution. No mesothelioma was found in the saline controls. All fiber samples were proficient in producing mesothelioma; the percentages were different between groups and untreated chrysotile but not significantly so. The differences may be explained on the basis of the number of fibers injected which were > 8 μm in length and < 0.25 μm in diameter. The findings of a proficiency of long fibers to produce mesothelioma, previously reported by others for glass fibers, could be applied to chrysotile.
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In the citing paper
“The important role of fibers corresponding to Stanton’s criteria (L > 8 μm; d ≤ 0.25 μm) has been evidenced in other reports where asbestos fibers were injected in the pleural cavity [74-76].”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [76]
In the citing paper
“Indeed the dimensional characteristics of asbestos fibers are an important parameter influencing carcinogenicity in animals, but this parameter does not fully explain the potency.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [76]
In the citing paper
“The results showed that the physico-chemical modification of the fibers influenced the relationship between the number of fibers and their potential carcinogenicity.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [76]
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Cited by
Boulanger, G., Andujar, P., Pairon, J.-C., Billon-Galland, M.-A., Dion, C., Dumortier, P., Brochard, P., Sobaszek, A., Bartsch, P., Paris, C., et al. (2014) · Environmental Health · doi:10.1186/1476-069x-13-59 · Cited by 176
Self-citationYegles, M., Saint-Etienne, L., Renier, A., Janson, X., & Jaurand, M.-C. (1993) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/9.2.186 · Cited by 62
Self-citation
Metadata
- Authors
- Van Der Meeren, A., Fleury, J., Nebut, M., Monchaux, G., Janson, X., & Jaurand, M. C.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 1992-04
- Volume
- 50
- Issue
- 6
- Pages
- 937-942
- ISSN
- 0020-7136
- 1097-0215
- Cited by
- 12
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Mesothelioma in rats following intrapleural injection of chrysotile and phosphorylated chrysotile (chrysophosphate). https://app.cochat.ai/papers/10.1002/ijc.2910500620
- The paper
- Van Der Meeren, A., Fleury, J., Nebut, M., Monchaux, G., Janson, X., & Jaurand, M. C. (1992). Mesothelioma in rats following intrapleural injection of chrysotile and phosphorylated chrysotile (chrysophosphate). International Journal of Cancer. https://doi.org/10.1002/ijc.2910500620
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
