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Mesotheliomas in rats following inoculation with acid-leached chrysotile asbestos and other mineral fibres
Abstract
The carcinogenicity of untreated UICC chrysotile A, of acid (oxalic and hydrochloric)-leached UICC chrysotile A, of crocidolite and of JM 104 glass fibres has been studied by intrapleural injection into rats. This experiment, carried out on 304 animals, demonstrated that when more than 80% of the Mg had been leached from chrysotile fibres by either hydrochloric or oxalic acid, the proportion of pleural mesotheliomas was either nil or dramatically lower than that obtained with untreated chrysotile. The carcinogenic effect of crocidolite was higher than that of 43.7% oxalic acid-leached chrysotile. The proportion of mesotheliomas observed in animals injected with JM 104 glass fibres was similar to that in animals injected with fibres from which 63.8% had been leached with oxalic acid. These results indicate that with regard to the induction of pleural carcinogenicity by chrysotile fibres, not only size characteristics but also parameters such as chemical composition and physiochemical properties must intervene.
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In the citing paper
“Acid treatment also resulted in shorter and thicker fibers, and greatly enhanced specific surface area, as measured by BET (Brunauer-Emmett-Teller) method.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [75]
In the citing paper
“In a study of the tumorigenicity of several samples of chrysotile, it was observed that the tumorigenic potential of different samples could also be explained by a difference in the chemical composition of the fibers [75].”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [75]
In the citing paper
“An inverse relationship was found between magnesium loss and tumorigenicity.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [75]
In the citing paper
“The results showed that the physico-chemical modification of the fibers influenced the relationship between the number of fibers and their potential carcinogenicity.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [75]
In the citing paper
“A decrease in carcinogenicity was observed with the treated sample suggesting that, directly or indirectly, the chemical composition of the fibers modulated their activity.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [75]
In the citing paper
“The important role of fibers corresponding to Stanton’s criteria (L > 8 μm; d ≤ 0.25 μm) has been evidenced in other reports where asbestos fibers were injected in the pleural cavity [74-76].”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [75]
In the citing paper
“Indeed the dimensional characteristics of asbestos fibers are an important parameter influencing carcinogenicity in animals, but this parameter does not fully explain the potency.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [75]
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Boulanger, G., Andujar, P., Pairon, J.-C., Billon-Galland, M.-A., Dion, C., Dumortier, P., Brochard, P., Sobaszek, A., Bartsch, P., Paris, C., et al. (2014) · Environmental Health · doi:10.1186/1476-069x-13-59 · Cited by 176
Self-citationRole of Mutagenicity in Asbestos Fiber-Induced Carcinogenicity and Other Diseases
Huang, S. X. L., Jaurand, M.-C., Kamp, D. W., Whysner, J., & Hei, T. K. (2011) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937404.2011.556051 · Cited by 163
Self-citationFavero-Longo, S. E., Turci, F., Tomatis, M., Castelli, D., Bonfante, P., Hochella, M. F., Piervittori, R., & Fubini, B. (2005) · Journal of Environmental Monitoring · doi:10.1039/b507569f · Cited by 62
Soil Fungi Reduce the Iron Content and the DNA Damaging Effects of Asbestos Fibers
Daghino, S., Turci, F., Tomatis, M., Favier, A., Perotto, S., Douki, T., & Fubini, B. (2006) · Environmental Science & Technology · doi:10.1021/es060881v · Cited by 52
A Biomimetic Approach to the Chemical Inactivation of Chrysotile Fibres by Lichen Metabolites
Turci, F., Favero‐Longo, S. E., Tomatis, M., Martra, G., Castelli, D., Piervittori, R., & Fubini, B. (2007) · Chemistry – A European Journal · doi:10.1002/chem.200600991 · Cited by 49
Metadata
- Authors
- Monchaux, G., Bignon, J., Jaurand, M. C., Lafuma, J., Sebastien, P., Masse, R., Hirsch, A., & Goni, J.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1981
- Volume
- 2
- Issue
- 3
- Pages
- 229-236
- ISSN
- 0143-3334
- 1460-2180
- Cited by
- 76
- References
- 0
- Language
- en
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- This page
- CoChat. (2026). Citation check: Mesotheliomas in rats following inoculation with acid-leached chrysotile asbestos and other mineral fibres. https://app.cochat.ai/papers/10.1093/carcin/2.3.229
- The paper
- Monchaux, G., Bignon, J., Jaurand, M. C., Lafuma, J., Sebastien, P., Masse, R., Hirsch, A., & Goni, J. (1981). Mesotheliomas in rats following inoculation with acid-leached chrysotile asbestos and other mineral fibres. Carcinogenesis. https://doi.org/10.1093/carcin/2.3.229
