The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
nmb, a novel gene, is expressed in low‐metastatic human melanoma cell lines and xenografts
Open accessAbstract
From a subtractive cDNA library, we isolated several cDNA clones which showed differential expression between highly and lowly metastatic human melanoma cell lines. One clone, designated nmb, showed preferential expression in the low‐meta‐static cell lines and was chosen for further characterization. Sequence analysis revealed that this clone represents a novel gene, encoding a putative transmembrane glycoprotein which showed the highest homology to the precursor of pMEL17, a melanocyte‐specific protein. nmb RNA expression was absent in most tumor‐cell lines tested and not restricted to the melanocytic lineage. Transfection of a partial nmb cDNA into a highly metastatic melanoma cell line (BLM) resulted, in 2 of 3 transfectants, in slower subcutaneous tumor growth and, in 1 of 3 transfectants, in reduction of the potential for spontaneous metastasis in nude mice. © 1995 Wiley‐Liss, Inc.
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A cell cycle regulator potentially involved in genesis of many tumor types
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Cited by
Suda, M., Shimizu, I., Katsuumi, G., Yoshida, Y., Hayashi, Y., Ikegami, R., Matsumoto, N., Yoshida, Y., Mikawa, R., Katayama, A., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00151-2 · Cited by 290
The Silver locus product Pmel17/gp100/Silv/ME20: controversial in name and in function
Theos, A. C., Truschel, S. T., Raposo, G., & Marks, M. S. (2005) · Pigment Cell Research · doi:10.1111/j.1600-0749.2005.00269.x · Cited by 224
The Role of GPNMB in Inflammation
Saade, M., Araujo de Souza, G., Scavone, C., & Kinoshita, P. F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674739 · Cited by 216
Hüttenrauch, M., Ogorek, I., Klafki, H., Otto, M., Stadelmann, C., Weggen, S., Wiltfang, J., & Wirths, O. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0612-3 · Cited by 166
GPNMB confers risk for Parkinson’s disease through interaction with α-synuclein
Diaz-Ortiz, M. E., Seo, Y., Posavi, M., Carceles Cordon, M., Clark, E., Jain, N., Charan, R., Gallagher, M. D., Unger, T. L., Amari, N., et al. (2022) · Science · doi:10.1126/science.abk0637 · Cited by 158
Metadata
- Authors
- Weterman, M. A. J., Ajubi, N., van Dinter, I. M. R., Degen, W. G. J., van Muijen, G. N. P., Ruiter, D. J., & Bloemers, H. P. J.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 1995-01-03
- Volume
- 60
- Issue
- 1
- Pages
- 73-81
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2119427647
- Cited by
- 256
- References
- 23
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: nmb, a novel gene, is expressed in low‐metastatic human melanoma cell lines and xenografts. https://app.cochat.ai/papers/10.1002/ijc.2910600111
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- Weterman, M. A. J., Ajubi, N., van Dinter, I. M. R., Degen, W. G. J., van Muijen, G. N. P., Ruiter, D. J., & Bloemers, H. P. J. (1995). nmb, a novel gene, is expressed in low‐metastatic human melanoma cell lines and xenografts. International Journal of Cancer. https://doi.org/10.1002/ijc.2910600111
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