The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
HIF‐1 at the crossroads of hypoxia, inflammation, and cancer
Open accessAbstract
The complex cross‐talk of intricate intercellular signaling networks between the tumor and stromal cells promotes cancer progression. Hypoxia is one of the most common conditions encountered within the tumor microenvironment that drives tumorigenesis. Most responses to hypoxia are elicited by a family of transcription factors called hypoxia‐inducible factors (HIFs), which induce expression of a diverse set of genes that assist cells to adapt to hypoxic environments. Among the three HIF protein family members, the role of HIF‐1 is well established in cancer progression. HIF‐1 functions as a signaling hub to coordinate the activities of many transcription factors and signaling molecules that impact tumorigenesis. This mini review discusses the complex role of HIF‐1 and its context‐dependent partners under various cancer‐promoting events including inflammation and generation of cancer stem cells, which are implicated in tumor metastasis and relapse. In addition, the review highlights the importance of therapeutic targeting of HIF‐1 for cancer prevention.
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4 retracted
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RetractedProcollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
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Prospective identification of tumorigenic breast cancer cells
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The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
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Cited by
Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
Wu, Q., You, L., Nepovimova, E., Heger, Z., Wu, W., Kuca, K., & Adam, V. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01292-6 · Cited by 485
Impact of Metabolic Syndrome on Neuroinflammation and the Blood–Brain Barrier
Van Dyken, P., & Lacoste, B. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00930 · Cited by 359
Xanthine Oxidoreductase‐Derived Reactive Species: Physiological and Pathological Effects
Battelli, M. G., Polito, L., Bortolotti, M., & Bolognesi, A. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3527579 · Cited by 281
HIF-1 in cancer therapy: two decade long story of a transcription factor
Soni, S., & Padwad, Y. S. (2017) · Acta Oncologica · doi:10.1080/0284186x.2017.1301680 · Cited by 251
“cell proliferation/viability, invasion and metastasis [9].”
BackgroundHypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance
Belisario, D. C., Kopecka, J., Pasino, M., Akman, M., De Smaele, E., Donadelli, M., & Riganti, C. (2020) · Cells · doi:10.3390/cells9122598 · Cited by 133
Metadata
- Authors
- Balamurugan, K.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2015-04-07
- Volume
- 138
- Issue
- 5
- Pages
- 1058-1066
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1557991089
- Cited by
- 572
- References
- 155
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- green
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