RETRACTED ARTICLE: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
Open accessAbstract
Most cases of breast cancer (BrCa) mortality are due to vascular metastasis. BrCa cells must intravasate through endothelial cells (ECs) to enter a blood vessel in the primary tumor and then adhere to ECs and extravasate at the metastatic site. In this study we demonstrate that inhibition of hypoxia-inducible factor (HIF) activity in BrCa cells by RNA interference or digoxin treatment inhibits primary tumor growth and also inhibits the metastasis of BrCa cells to the lungs by blocking the expression of angiopoietin-like 4 (ANGPTL4) and L1 cell adhesion molecule (L1CAM). ANGPTL4 is a secreted factor that inhibits EC-EC interaction, whereas L1CAM increases the adherence of BrCa cells to ECs. Interference with HIF, ANGPTL4 or L1CAM expression inhibits vascular metastasis of BrCa cells to the lungs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HIF-1α-dependent expression of angiopoietin-like 4 and the L1 cell adhesion molecule further modulate intra- and extravasation.
“HIF-1α-dependent expression of angiopoietin-like 4 and the L1 cell adhesion molecule further modulate intra-and extravasation (Zhang et al., 2012).”
From Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer (2016) · cites this paper as Zhang et al., 2012
The Results sections “ANGPTL4 promotes extravasation of BrCa cells in the lungs” and “L1CAM promotes extravasation” report that both factors promote extravasation; the Discussion describes their HIF-1-dependent expression. The paper mentions intravasation as a step in metastasis, but the passages do not show that ANGPTL4 or L1CAM modulates it. Page numbers were not provided. (LLM, conf=0.88)
Experimental — accuracy not yet measuredHIF-1α inhibition has shown success as a therapeutic strategy in mouse models of metastatic breast cancer.
“HIF-1α inhibition has shown success as a therapeutic strategy in mouse models of metastatic breast cancer6, 7.”
From Liposomal Formulation of HIF-1α Inhibitor Echinomycin Eliminates Established Metastases of Triple-negative Breast Cancer (2020) · cites this paper as [6]
Double-knockdown of HIF1A and HIF2A in MDA-MB-231 cells impairs primary tumor growth and lung metastasis in vivo.
“Double-knockdown of HIF1A and HIF2A in MDA-MB-231 cells was reported to impair primary tumor growth and lung metastasis in vivo6.”
From Liposomal Formulation of HIF-1α Inhibitor Echinomycin Eliminates Established Metastases of Triple-negative Breast Cancer (2020) · cites this paper as [6]
Inactivation of HIF decreases the metastatic potential of tumor cells.
“whereas inactivation of HIF decreases the metastatic potential of tumor cells”
From Hypoxic control of metastasis (2016) · cites this paper as [45]
Knockdown of HIF-1α, HIF-2α, or both in human MDA-MB-231 breast cancer cells significantly decreased the number of spontaneous lung metastases and total lung metastatic burden in immunodeficient mice after mammary fat pad injection.
“Knockdown of HIF-1α, HIF-2α, or both in human MDA-MB-231 BCCs significantly decreased the number of spontaneous lung metastases and total lung metastatic burden in immunodeficient mice after mammary fat pad injection [35].”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [35]
Exposure of MDA-MB-231 cells to 1% O2 for 48 hours increased their adherence to vascular endothelial cells, due to HIF-dependent activation of L1 cell adhesion molecule expression.
“Exposure of MDA-MB-231 cells to 1% O2 for 48 hours increased their adherence to vascular ECs, due to the HIF-dependent activation of L1 cell adhesion molecule (L1CAM) expression [35].”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [35]
ANGPTL4 expression is induced by hypoxia in a HIF-dependent manner.
“ANGPTL4 expression is induced by hypoxia in a HIF-dependent manner [35].”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [35]
Breast cancer cells secrete angiopoietin-like 4, which binds to receptors on endothelial cells and inhibits endothelial cell-endothelial cell interactions, enabling extravasation.
“In order for BCCs to migrate between adjacent ECs, they secrete angiopoietin-like 4 (ANGPTL4), which binds to receptors on ECs and inhibits EC-EC interactions [35, 76].”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [35]
Knockdown of ANGPTL4 expression in MDA-MB-231 cells had no effect on primary tumor growth but dramatically impaired hypoxia-induced extravasation after intravenous injection and lung metastasis after mammary fat pad implantation.
“Knockdown of ANGPTL4 expression in MDA-MB-231 cells had no effect on primary tumor growth but dramatically impaired hypoxia-induced extravasation after intravenous injection and lung metastasis after mammary fat pad implantation [35, 76].”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [35]
Knockdown of L1CAM markedly impaired adherence of breast cancer cells to vascular endothelial cells ex vivo, reduced lung colonization after intravenous injection, and decreased the number of spontaneous lung metastases after mammary fat pad implantation.
“Knockdown of L1CAM markedly impaired adherence of BCCs to vascular ECs ex vivo, reduced lung colonization after intravenous injection, and decreased the number of spontaneous lung metastases after mammary fat pad implantation [35].”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [35]
Acriflavine, digoxin, and ganetespib block breast cancer primary tumor growth, angiogenesis, pre-metastatic niche formation, local invasion, and metastasis to lymph nodes and lungs in orthotopic mouse models.
“There are now several drugs (acriflavine, digoxin, and ganetespib) that have been shown to inhibit HIF-1 and shown to block breast cancer primary tumor growth, angiogenesis, pre-metastatic niche formation, and local invasion as well as metastasis to lymph nodes and lungs in orthotopic mouse models [31, 35, 60, 104].”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [35]
Acriflavine, digoxin, and ganetespib inhibit HIF-1.
“There are now several drugs (acriflavine, digoxin, and ganetespib) that have been shown to inhibit HIF-1 and shown to block breast cancer primary tumor growth, angiogenesis, pre-metastatic niche formation, and local invasion as well as metastasis to lymph nodes and lungs in orthotopic mouse models [31, 35, 60, 104].”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309 · see citing works
RetractedMolecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works
Self-citationGenes that mediate breast cancer metastasis to lung
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922 · see citing works
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
Semenza, G. L. (2010) · Oncogene · doi:10.1038/onc.2009.441 · Cited by 1,712 · see citing works
Self-citationErler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q.-T., & Giaccia, A. J. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.11.012 · Cited by 1,231 · see citing works
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
Fukuda, R., Zhang, H., Kim, J.-W., Shimoda, L., Dang, C. V., & Semenza, G. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.047 · Cited by 1,225 · see citing works
Self-citationAACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective
Talmadge, J. E., & Fidler, I. J. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1040 · Cited by 1,172 · see citing works
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
Manalo, D. J., Rowan, A., Lavoie, T., Natarajan, L., Kelly, B. D., Ye, S. Q., Garcia, J. G. N., & Semenza, G. L. (2005) · Blood · doi:10.1182/blood-2004-07-2958 · Cited by 1,154 · see citing works
Self-citationCycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
Dewhirst, M. W., Cao, Y., & Moeller, B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2397 · Cited by 1,022 · see citing works
Breast Tumor Cell Lines From Pleural Effusions2
Cailleau, R., Young, R. K., Olivé, M., & Reeves, W. J. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.3.661 · Cited by 1,019 · see citing works
TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
Padua, D. M., Zhang, X. H.-F., Wang, Q., Nadal, C., Gerald, W. L., Gomis, R. R., & Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.01.046 · Cited by 947 · see citing works
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
Gupta, G. P., Nguyen, D. X., Chiang, A. C., Bos, P. D., Kim, J. Y., Nadal, C., Gomis, R. R., Manova-Todorova, K. O., & Massagué, J. (2007) · Nature · doi:10.1038/nature05760 · Cited by 728 · see citing works
Caniggia, I., Mostachfi, H., Winter, J., Gassmann, M., Lye, S. J., Kuliszewski, M., & Post, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8316 · Cited by 644 · see citing works
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
Zhang, H., Qian, D. Z., Tan, Y. S., Lee, K., Gao, P., Ren, Y. R., Rey, S., Hammers, H., Chang, D., Pili, R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809763105 · Cited by 624 · cited 6× · see citing works
“To complement this genetic approach, in which HIF activity was inhibited in cancer cells before implantation, we treated mice bearing established tumors with digoxin, which inhibits translation of HIF-1a and HIF-2a mRNA into protein by an mTOR-independent mechanism (Zhang et al., 2008).”
BackgroundMethodInfluentialSelf-citationLevels of Hypoxia-Inducible Factor-1 During Breast Carcinogenesis
Bos, R., Zhong, H., Hanrahan, C. F., Mommers, E. C. M., Semenza, G. L., Pinedo, H. M., Abeloff, M. D., Simons, J. W., van Diest, P. J., & van der Wall, E. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.309 · Cited by 593 · see citing works
Self-citationBuffa, F. M., Harris, A. L., West, C., & Miller, C. J. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605450 · Cited by 558 · see citing works
Bos, R., van der Groep, P., Greijer, A. E., Shvarts, A., Meijer, S., Pinedo, H. M., Semenza, G. L., van Diest, P. J., & van der Wall, E. (2003) · Cancer · doi:10.1002/cncr.11246 · Cited by 500 · see citing works
Self-citationTumor hypoxia and malignant progression
Vaupel, P., Mayer, A., & Höckel, M. (2004) · Methods in Enzymology · doi:10.1016/s0076-6879(04)81023-1 · Cited by 496 · see citing works
Krishnamachary, B., Zagzag, D., Nagasawa, H., Rainey, K., Okuyama, H., Baek, J. H., & Semenza, G. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3719 · Cited by 415 · see citing works
Self-citation(2002) · PubMed · Cited by 385 · see citing works
Gordon, M. S. (2007) · Yearbook of Oncology · doi:10.1016/s1040-1741(08)70352-x · Cited by 346 · see citing works
Liao, D., Corle, C., Seagroves, T. N., & Johnson, R. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2701 · Cited by 339 · see citing works
The hypoxic tumour microenvironment and metastatic progression
Subarsky, P., & Hill, R. P. (2003) · Clinical & Experimental Metastasis · doi:10.1023/a:1022939318102 · Cited by 327 · see citing works
Triple negative breast cancer: unmet medical needs
Pal, S. K., Childs, B. H., & Pegram, M. D. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1293-1 · Cited by 323 · see citing works
Dalès, J.-P., Garcia, S., Meunier-Carpentier, S., Andrac, L., Haddad, O., Lavaut, M., Allasia, C., Bonnier, P., & Charpin, C. (2005) · International Journal of Cancer · doi:10.1002/ijc.20984 · Cited by 263 · see citing works
Galaup, A., Cazes, A., Jan, S. L., Philippe, J., Connault, E., Coz, E. L., Mekid, H., Mir, L. M., Opolon, P., Corvol, P. L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609025103 · Cited by 252 · see citing works
Generali, D., Berruti, A., Brizzi, M. P., Campo, L., Bonardi, S., Wigfield, S., Bersiga, A., Allevi, G., Milani, M., Aguggini, S., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2690 · Cited by 250 · see citing works
Targeting hypoxia cell signaling for cancer therapy
Melillo, G. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9059-x · Cited by 230 · see citing works
Vleugel, M. M., Greijer, A. E., Shvarts, A., van der Groep, P., van Berkel, M., Aarbodem, Y., van Tinteren, H., Harris, A. L., van Diest, P. J., & van der Wall, E. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2004.019885 · Cited by 227 · see citing works
HIF‐1α and CA IX staining in invasive breast carcinomas: Prognosis and treatment outcome
Trastour, C., Benizri, E. I., Ettore, F., Ramaioli, A., Chamorey, E., Pouysségur, J., & Berra, E. (2007) · International Journal of Cancer · doi:10.1002/ijc.22436 · Cited by 226 · see citing works
MDA-MB-435 and M14 Cell Lines: Identical but not M14 Melanoma?
Chambers, A. F. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1528 · Cited by 218 · see citing works
Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer
Yamamoto, Y., Ibusuki, M., Okumura, Y., Kawasoe, T., Kai, K., Iyama, K., & Iwase, H. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9742-1 · Cited by 151 · see citing works
Ueno, M., Maeno, T., Nomura, M., Aoyagi, K., Matsui, H., Hara, K., Tanaka, T., Iso, T., Suga, T., & Kurabayashi, M. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00146.2010 · Cited by 140 · see citing works
Belanger, A. J., Lu, H., Date, T., Liu, L. X., Vincent, K. A., Akita, G. Y., Cheng, S. H., Gregory, R. J., & Jiang, C. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.2021 · Cited by 137 · see citing works
Helczynska, K., Larsson, A.-M., Holmquist Mengelbier, L., Bridges, E., Fredlund, E., Borgquist, S., Landberg, G., Påhlman, S., & Jirström, K. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1135 · Cited by 136 · see citing works
Verheul, H. M. W., Salumbides, B. C., van Erp, K., Hammers, H. J., Qian, D. Z., Sanni, T. B., Atadja, P. W., & Пили, Р. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4306 · Cited by 103 · see citing works
Hypoxia-Inducible Factor-1 Transactivates Transforming Growth Factor-β3 in Trophoblast
Nishi, H., Nakada, T., Hokamura, M., Osakabe, Y., 糸数, 修., Huang, E. L., & Isaka, K. (2004) · Endocrinology · doi:10.1210/en.2003-1639 · Cited by 95 · see citing works
Kronblad, Å., Jirström, K., Rydén, L., Nordenskjöld, B. A., & Landberg, G. (2005) · International Journal of Cancer · doi:10.1002/ijc.21676 · Cited by 84 · see citing works
c- erb B-2 Related Aggressiveness in Breast Cancer Is Hypoxia Inducible Factor-1α Dependent
Giatromanolaki, A. N., Koukourakis, M. I., Simopoulos, C., Polychronidis, A., Gatter, K. C., Harris, A. L., & Sivridis, E. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1068 · Cited by 81 · see citing works
Chintala, S., Tóth, K., Cao, S., Durrani, F. A., Vaughan, M. M., Jensen, R. L., & Rustum, Y. M. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-009-1238-8 · Cited by 68 · see citing works
Tafani, M., Russo, A., Vito, M. D., Sale, P., Pellegrini, L., Schito, L., Gentileschi, S., Bracaglia, R., Marandino, F., Garaci, E., et al. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01493.x · Cited by 67 · see citing works
Self-citationRechallenging with anthracyclines and taxanes in metastatic breast cancer
Palmieri, C., Krell, J., James, C. R., Harper-Wynne, C. L., Misra, V., Cleator, S. J., & Miles, D. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.122 · Cited by 67 · see citing works
Issa, Y., Nummer, D., Seibel, T., Müerköster, S. S., Koch, M., Schmitz-Winnenthal, F. H., Galindo, L., Weitz, J., Beckhove, P., & Altevogt, P. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0410-7 · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hypoxia-inducible factors in physiology and medicine
Semenza, G. L. (2012) · Cell · doi:10.1016/j.cell.2012.01.021 · Cited by 3,645 · see citing works
Self-citationMetabolic reprogramming and cancer progression
Faubert, B., Solmonson, A., & DeBerardinis, R. J. (2020) · Science · doi:10.1126/science.aaw5473 · Cited by 2,740 · see citing works
Hypoxia and the extracellular matrix: drivers of tumour metastasis
Gilkes, D. M., Semenza, G. L., & Wirtz, D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3726 · Cited by 1,520 · see citing works
Self-citationHypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
Semenza, G. L. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.01.005 · Cited by 1,514 · see citing works
Self-citationRankin, E. B., & Giaccia, A. J. (2016) · Science · doi:10.1126/science.aaf4405 · Cited by 1,340 · see citing works
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
Semenza, G. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67230 · Cited by 1,335 · see citing works
Self-citationOxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
Semenza, G. L. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104720 · Cited by 1,159 · see citing works
Self-citationZhang, C., Samanta, D., Lu, H., Bullen, J. W., Zhang, H., Chen, I., He, X., & Semenza, G. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602883113 · Cited by 977 · see citing works
Self-citationHypoxia-Inducible Factors: Master Regulators of Cancer Progression
Schito, L., & Semenza, G. L. (2016) · Trends in Cancer · doi:10.1016/j.trecan.2016.10.016 · Cited by 962 · see citing works
Self-citationTherapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
Wigerup, C., Påhlman, S., & Bexell, D. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.009 · Cited by 687 · see citing works
“HIF-1α-dependent expression of angiopoietin-like 4 and the L1 cell adhesion molecule further modulate intra- and extravasation (Zhang et al., 2012).”
BackgroundIntegrins and cancer: regulators of cancer stemness, metastasis, and drug resistance
Seguin, L., Desgrosellier, J. S., Weis, S. M., & Cheresh, D. A. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.12.006 · Cited by 685 · see citing works
Hypoxia-Inducible Factor 1 and Cardiovascular Disease
Semenza, G. L. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170322 · Cited by 608 · see citing works
Self-citationHIF ‐1 at the crossroads of hypoxia, inflammation, and cancer
Balamurugan, K. (2015) · International Journal of Cancer · doi:10.1002/ijc.29519 · Cited by 571 · see citing works
Shukla, S. K., Purohit, V., Mehla, K., Gunda, V., Chaika, N. V., Vernucci, E., King, R. J., Abrego, J., Goode, G. D., Dasgupta, A., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.06.004 · Cited by 542 · see citing works
The hypoxic tumor microenvironment: A driving force for breast cancer progression
Semenza, G. L. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.05.036 · Cited by 535 · see citing works
Self-citationWang, T., Gilkes, D. M., Takano, N., Xiang, L., Luo, W., Bishop, C. J., Chaturvedi, P., Green, J. J., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410041111 · Cited by 493 · see citing works
Self-citationGilkes, D. M., Bajpai, S. K., Chaturvedi, P., Wirtz, D., & Semenza, G. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.442939 · Cited by 467 · see citing works
Self-citationRetractedSamanta, D., Gilkes, D. M., Chaturvedi, P., Xiang, L., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421438111 · Cited by 460 · see citing works
Self-citationRetractedZhang, H., Lu, H., Xiang, L., Bullen, J. W., Zhang, C., Samanta, D., Gilkes, D. M., He, J., & Semenza, G. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520032112 · Cited by 420 · see citing works
Self-citationTumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis
Eddy, R. J., Weidmann, M. D., Sharma, V. P., & Condeelis, J. S. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.03.003 · Cited by 375 · see citing works
HIFs, angiogenesis, and metabolism: Elusive enemies in breast cancer
de Heer, E. C., Jalving, M., & Harris, A. L. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137552 · Cited by 372 · see citing works
Huang, D., Li, T., Li, X., Zhang, L., Sun, L., He, X., Zhong, X., Jia, D., Song, L., Semenza, G. L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.028 · Cited by 352 · see citing works
Self-citationBiology, vulnerabilities and clinical applications of circulating tumour cells
Ring, A., Nguyen-Sträuli, B. D., WICKI, A. N., & Aceto, N. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00536-4 · Cited by 334 · see citing works
Chiang, S., Cabrera, R. M., & Segall, J. E. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00238.2015 · Cited by 310 · see citing works
Samanta, D., Park, Y., Ni, X., Li, H., Zahnow, C. A., Gabrielson, E., Pan, F., & Semenza, G. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718197115 · Cited by 302 · see citing works
Self-citationRETRACTED: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3963 · Cited by 296 · see citing works
Self-citationRetractedHypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis
Eisinger‐Mathason, T. S. K., Zhang, M., Qiu, Q., Skuli, N., Nakazawa, M. S., Karakasheva, T. A., Mucaj, V., Shay, J. E. S., Stangenberg, L., Sadri, N., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0118 · Cited by 280 · see citing works
Role of hypoxia-inducible factors in breast cancer metastasis
Gilkes, D. M., & Semenza, G. L. (2013) · Future Oncology · doi:10.2217/fon.13.92 · Cited by 274 · see citing works
Self-citationFate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
Godet, I., Shin, Y. J., Ju, J. A., Ye, I. C., Wang, G., & Gilkes, D. M. (2019) · Nature Communications · doi:10.1038/s41467-019-12412-1 · Cited by 274 · see citing works
Self-citationLu, H., Samanta, D., Xiang, L., Zhang, H., Hu, H., Chen, I., Bullen, J. W., & Semenza, G. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513433112 · Cited by 270 · see citing works
Self-citationZhang, C., Zhi, W. I., Lu, H., Samanta, D., Chen, I., Gabrielson, E., & Semenza, G. L. (2016) · Oncotarget · doi:10.18632/oncotarget.11743 · Cited by 261 · see citing works
Self-citationProcollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0629 · Cited by 252 · see citing works
Self-citationRetractedHypoxia-inducible factor 1 and breast cancer metastasis
Liu, Z.-J., Semenza, G. L., & Zhang, H.-F. (2015) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1400221 · Cited by 257 · see citing works
Self-citationHIF-1 in cancer therapy: two decade long story of a transcription factor
Soni, S., & Padwad, Y. S. (2017) · Acta Oncologica · doi:10.1080/0284186x.2017.1301680 · Cited by 251 · see citing works
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
Montagner, M., Enzo, E., Forcato, M., Zanconato, F., Parenti, A. R., Rampazzo, E., Basso, G., Leo, G., Rosato, A., Bicciato, S., et al. (2012) · Nature · doi:10.1038/nature11207 · Cited by 247 · see citing works
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation
Hubbi, M. E., Hu, H., Gupta, K., Ahmed, I., Levchenko, A., & Semenza, G. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.414771 · Cited by 239 · see citing works
Self-citationChaturvedi, P., Gilkes, D. M., Wong, C. C., Gupta, K., Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64993 · Cited by 241 · see citing works
Self-citationHypoxia: Signaling the Metastatic Cascade
Rankin, E. B., Nam, J.-M., & Giaccia, A. J. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.05.006 · Cited by 240 · see citing works
Samanta, D., Park, Y., Andrabi, S. A., Shelton, L. M., Gilkes, D. M., & Semenza, G. L. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0530 · Cited by 238 · see citing works
Self-citationRetractedParacrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
Briggs, K. J., Koivunen, P., Cao, S., Backus, K. M., Olenchock, B. A., Patel, H., Zhang, Q. H., Signoretti, S., Gerfen, G. J., Richardson, A. L., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.042 · Cited by 228 · see citing works
Luo, W., Chang, R., Zhong, J., Pandey, A., & Semenza, G. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217394109 · Cited by 228 · see citing works
Self-citationChaturvedi, P., Gilkes, D. M., Takano, N., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406655111 · Cited by 226 · see citing works
Self-citationSchito, L., Rey, S., Tafani, M., Zhang, H., Wong, C. C.-L., Russo, A., Russo, M. A., & Semenza, G. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214019109 · Cited by 224 · see citing works
Self-citationWong, C. C., Zhang, H., Gilkes, D. M., Chen, J., Wei, H., Chaturvedi, P., Hubbi, M. E., & Semenza, G. L. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0855-y · Cited by 224 · see citing works
Self-citationXiang, L., Mou, J., Shao, B., Wei, Y., Liang, H., Takano, N., Semenza, G. L., & Xie, G. (2019) · Cell Death & Disease · doi:10.1038/s41419-018-1291-5 · Cited by 223 · see citing works
Self-citationSchwab, L. P., Peacock, D. L., Majumdar, D., Ingels, J. F., Jensen, L. C., Smith, K., Cushing, R. C., & Seagroves, T. N. (2012) · Breast Cancer Research · doi:10.1186/bcr3087 · Cited by 220 · see citing works
Liang, X., Chen, M., Bhattarai, P., Hameed, S., & Dai, Z. (2020) · ACS Nano · doi:10.1021/acsnano.0c05617 · Cited by 220 · see citing works
Molecular mechanisms mediating metastasis of hypoxic breast cancer cells
Semenza, G. L. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.08.001 · Cited by 217 · see citing works
Self-citationSemenza, G. L. (2012) · Oncogene · doi:10.1038/onc.2012.578 · Cited by 201 · see citing works
Self-citationEmerging Roles of Angiopoietin-like 4 in Human Cancer
Tan, M., Teo, Z., Sng, M. K., Zhu, P., & Tan, N. S. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0519 · Cited by 197 · see citing works
Hypoxia-regulated target genes implicated in tumor metastasis
Tsai, Y.-P., & Wu, K.-J. (2012) · Journal of Biomedical Science · doi:10.1186/1423-0127-19-102 · Cited by 190 · see citing works
Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors
Samanta, D., & Semenza, G. L. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.07.002 · Cited by 190 · see citing works
Self-citationPotential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence
Vissers, M. C. M., & Das, A. B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00809 · Cited by 188 · see citing works
Gilkes, D. M., Xiang, L., Lee, S. J., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321510111 · Cited by 184 · see citing works
Self-citationRetractedThe Metabolic Mechanisms of Breast Cancer Metastasis
Wang, L., Zhang, S., & Wang, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.602416 · Cited by 191 · see citing works
Hypoxia-inducible factors and innate immunity in liver cancer
Yuen, V. W., & Wong, C. C. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137553 · Cited by 182 · see citing works
Self-citationZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis
Chen, Y., Zhang, B., Bao, L., Jin, L., Yang, M., Peng, Y., Kumar, A., Wang, J. E., Wang, C., Zou, X., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95089 · Cited by 176 · see citing works
Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4
Drager, L. F., Yao, Q., Hernandez, K. L., Shin, M.-K., Bevans-Fonti, S., Gay, J., Sussan, T. E., Jun, J. C., Myers, A. C., Olivecrona, G., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201209-1688oc · Cited by 175 · see citing works
Self-citationAre Integrins Still Practicable Targets for Anti-Cancer Therapy?
Alday-Parejo, B., Stupp, R., & Rüegg, C. (2019) · Cancers · doi:10.3390/cancers11070978 · Cited by 175 · see citing works
Molecular targeting of hypoxia in radiotherapy
Rey, S., Schito, L., Koritzinsky, M., & Wouters, B. G. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.10.002 · Cited by 171 · see citing works
Self-citationXin, X., Rodrigues, M. W., Umapathi, M., Kashiwabuchi, F., Ma, T., Babapoor-Farrokhran, S., Wang, S., Hu, J., Bhutto, I. A., Welsbie, D. S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217091110 · Cited by 165 · see citing works
Self-citationBui, B. P., Nguyen, P. L., Lee, K., & Cho, J. (2022) · Cancers · doi:10.3390/cancers14246054 · Cited by 164 · see citing works
Hypoxia and Metabolic Properties of Hematopoietic Stem Cells
Zhang, C. C., & Sadek, H. A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5019 · Cited by 154 · see citing works
The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression
Amelio, I., & Melino, G. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.04.007 · Cited by 151 · see citing works
Hu, K., Babapoor-Farrokhran, S., Rodrigues, M. W., Deshpande, M. M., Puchner, B., Kashiwabuchi, F., Hassan, S. J., Asnaghi, L., Handa, J. T., Merbs, S. L., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6868 · Cited by 150 · see citing works
Self-citationHypoxia-Driven Effects in Cancer: Characterization, Mechanisms, and Therapeutic Implications
Shi, R., Liao, C., & Zhang, Q. H. (2021) · Cells · doi:10.3390/cells10030678 · Cited by 148 · see citing works
Yousefi, M., Nosrati, R., Salmaninejad, A., Dehghani, S., Shahryari, A., & Saberi, A. (2018) · Cellular Oncology · doi:10.1007/s13402-018-0376-6 · Cited by 141 · see citing works
Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness
Lu, H., Xie, Y., Tran, T. M. L., Lan, J., Yang, Y., Murugan, N. L., Wang, R., Wang, Y. J., & Semenza, G. L. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138577 · Cited by 140 · see citing works
Self-citationBabapoor-Farrokhran, S., Jee, K. J., Puchner, B., Hassan, S. J., Xin, X., Rodrigues, M. W., Kashiwabuchi, F., Ma, T., Hu, K., Deshpande, M. M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423765112 · Cited by 138 · see citing works
Self-citationHypoxia-Induced Secretion of TGF-β1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression
Hung, S.-P., Yang, M.-H., Tseng, K.-F., & Lee, O. K. (2013) · Cell Transplantation · doi:10.3727/096368912x657954 · Cited by 137 · see citing works
Ju, J. A., Godet, I., Ye, I. C., Byun, J., Jayatilaka, H., Lee, S. J., Xiang, L., Samanta, D., Lee, M., Wu, P.-H., et al. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0338 · Cited by 128 · see citing works
Self-citationLan, J., Lu, H., Samanta, D., Salman, S., Lü, Y., & Semenza, G. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809695115 · Cited by 127 · see citing works
Self-citationThe potential role of HIF on tumour progression and dissemination
Unwith, S., Zhao, H., Hennah, L., & Ma, D. (2014) · International Journal of Cancer · doi:10.1002/ijc.28889 · Cited by 126 · see citing works
Qannita, R. A., Alalami, A., Harb, A. A., Aleidi, S. M., Taneera, J., Abu‐Gharbieh, E., El‐Huneidi, W., Saleh, M. A., Alzoubi, K. H., Semreen, M. H., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17020195 · Cited by 122 · see citing works
Evaluating the Cancer Therapeutic Potential of Cardiac Glycosides
Calderón‐Montaño, J. M., Burgos‐Morón, E., Orta, M. L., Maldonado-Navas, D., García-Domínguez, I., & López‐Lázaro, M. (2014) · BioMed Research International · doi:10.1155/2014/794930 · Cited by 123 · see citing works
Xiang, L., Gilkes, D. M., Hu, H., Takano, N., Luo, W., Lu, H., Bullen, J. W., Samanta, D., Liang, H., & Semenza, G. L. (2014) · Oncotarget · doi:10.18632/oncotarget.2997 · Cited by 119 · see citing works
Self-citationCurrent developments in nanotechnology for improved cancer treatment, focusing on tumor hypoxia
Phung, C. D., Tran, T. H., Pham, L. M., Nguyen, H. T., Jeong, J., Yong, C. S., & Kim, J. O. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.05.029 · Cited by 115 · see citing works
Xiang, L., Gilkes, D. M., Chaturvedi, P., Luo, W., Hu, H., Takano, N., Liang, H., & Semenza, G. L. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1102-5 · Cited by 114 · see citing works
Self-citationAryal, B., Rotllán, N., Araldi, E., Ramírez, C. M., He, S., Chousterman, B. G., Fenn, A. M., Wanschel, A. C. B. A., Madrigal‐Matute, J., Warrier, N., et al. (2016) · Nature Communications · doi:10.1038/ncomms12313 · Cited by 114 · see citing works
Targeting Hypoxia-Inducible Factors for Antiangiogenic Cancer Therapy
Rey, S., Schito, L., Wouters, B. G., Eliasof, S. D., & Kerbel, R. S. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.05.002 · Cited by 114 · see citing works
Self-citationTumor Cells Upregulate Normoxic HIF-1α in Response to Doxorubicin
Cao, Y., Eble, J. M., Moon, E., Yuan, H., Weitzel, D. H., Landon, C. D., Yu-Chih Nien, C., Hanna, G., Rich, J. N., Provenzale, J. M., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-1345 · Cited by 111 · see citing works
EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination
Gómez-Maldonado, L., Tiana, M., Roche, O., Prado‐Cabrero, A., Jensen, L. D., Fernández‐Barral, A., Guijarro-Muñoz, I., Favaro, E., Moreno‐Bueno, G., Sanz, L., et al. (2014) · Oncogene · doi:10.1038/onc.2014.200 · Cited by 111 · see citing works
Herrera, I., Cisneros, J., Maldonado, M., Ramı́rez, R., Ortíz-Quintero, B., Ansó, E., Chandel, N. S., Selman, M., & Pardo, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.459784 · Cited by 109 · see citing works
Sun, Y.-W., Chen, Y.-F., Li, J., Huo, Y.-M., Liu, D.-J., Hua, R., Zhang, J.-F., Liu, W., Yang, J.-Y., Fu, X.-L., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.520 · Cited by 106 · see citing works
Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema
Sodhi, A., Ma, T., Menon, D., Deshpande, M. M., Jee, K. J., Dinabandhu, A., Vancel, J., Lu, D., & Montaner, S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci120879 · Cited by 104 · see citing works
HIF1A signaling selectively supports proliferation of breast cancer in the brain
Ebright, R. Y., Zachariah, M. A., Micalizzi, D. S., Wittner, B. S., Niederhoffer, K., Nieman, L. T., Chirn, B., Wiley, D. F., Wesley, B., Shaw, B. L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20144-w · Cited by 104 · see citing works
Yang, Y., Lu, H., Chen, C. O., Lyu, Y., Cole, R. N., & Semenza, G. L. (2022) · Nature Communications · doi:10.1038/s41467-021-27944-8 · Cited by 103 · see citing works
Self-citationZhang, J., Hu, Z., Horta, C. A., & Yang, J. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.12.002 · Cited by 103 · see citing works
LASP1 Is a HIF1α Target Gene Critical for Metastasis of Pancreatic Cancer
Zhao, T., Ren, H., Li, J., Chen, J., Zhang, H., Xin, W., Sun, Y. K., Sun, L., Yang, Y., Sun, J., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-2040 · Cited by 101 · see citing works
Self-citationMimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models
Bhattacharya, S., Calar, K., & de la Puente, P. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01583-1 · Cited by 100 · see citing works
Hypoxia in Breast Cancer—Scientific Translation to Therapeutic and Diagnostic Clinical Applications
Zhang, Y., Zhang, H., Wang, M., Schmid, T., Xin, Z., Kozhuharova, L., Yu, W.-K., Huang, Y., Cai, F., & Biskup, E. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.652266 · Cited by 100 · see citing works
Self-citationSarkar, K., Cai, Z. P., Gupta, R., Parajuli, N., Fox-Talbot, K., Darshan, M. S., Gonzalez, F. J., & Semenza, G. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208314109 · Cited by 97 · see citing works
Self-citationGao, T., Li, J.-Z., Lü, Y., Zhang, C., Li, Q., Mao, J., & Li, L. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.02.044 · Cited by 94 · see citing works
Wang, Y., Lyu, Y., Tu, K., Xu, Q., Yang, Y., Salman, S., Le, N., Lu, H., Chen, C. O., Zhu, Y., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe3771 · Cited by 95 · see citing works
Self-citationYang, Z., Luo, Y., Yu, H., Liang, K., Wang, M., Wang, Q., Yin, B., & Chen, H. (2021) · Advanced Materials · doi:10.1002/adma.202108908 · Cited by 95 · see citing works
Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis
Wang, R., Godet, I., Yang, Y., Salman, S., Lu, H., Lyu, Y., Zuo, Q., Wang, Y., Zhu, Y., Chen, C. O., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020490118 · Cited by 93 · see citing works
Self-citationWhelan, K. A., Schwab, L. P., Karakashev, S. V., Franchetti, L. D., Johannes, G. J., Seagroves, T. N., & Reginato, M. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.426999 · Cited by 93 · see citing works
NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma
Lai, R. K., Xu, M., Chiu, D. K., Tse, A. P., Wei, L. L., Law, C., Lee, D. P. H., Wong, C., Wong, M. P., Ng, I. O., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1987 · Cited by 91 · see citing works
Self-citationWei, Z., Shan, Y., Li, T., Liu, Y., Zhu, Z., Liu, Z., Wu, Y., Chen, W., Wang, A., & Lu, Y. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22686 · Cited by 92 · see citing works
Lu, H., Tran, T. M. L., Park, Y., Chen, I., Lan, J., Xie, Y., & Semenza, G. L. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0270 · Cited by 92 · see citing works
Self-citation
- Authors
- Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., Raman, V, Zhen, L., Mitzner, W. A., Sukumar, S., & Semenza, G. L.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Semenza, G L
- ORCID
- Venue
- Oncogene
- Published
- 2011-08-22
- Volume
- 31
- Issue
- 14
- Pages
- 1757-1770
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- PMC
- PMC3223555
- OpenAlex
- W2020105314
- Cited by
- 326
- References
- 44
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 13 · 2023: 15 · 2022: 29 · 2021: 30 · 2020: 33 · 2019: 25 · 2018: 21 · 2017: 26 · 2016: 29 · 2015: 24 · 2014: 27 · 2013: 30 · 2012: 20
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Johns Hopkins University
- Emerald Foundation
- National Cancer Institute (U54CA143868, T32CA130840)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- breast cancer, vascular metastasis, HIF-1, ANGPTL4, L1CAM, hypoxia, lung metastasis, endothelial cells, tumor cell adhesion, intravasation, digoxin, retracted article
- MeSH terms
- Angiopoietin-like Proteins, Angiopoietin-Like Protein 3, Animals, Breast Neoplasms, Female, Humans, Lung Neoplasms, Neoplasm Transplantation, Spermidine, Cell Hypoxia, RNA Interference, Angiopoietins, Cell Line, Tumor, Mice, Hypoxia-Inducible Factor 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
