The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents
Open accessAbstract
Cancer cells exhibit an altered metabolism which is characterized by a preference for aerobic glycolysis more than mitochondrial oxidation of pyruvate. This provides anabolic support and selective growth advantage for cancer cells. Recently, a new concept has arisen suggesting that these metabolic changes may be due, in part, to an attenuated mitochondrial function which results from the inhibition of the pyruvate dehydrogenase complex (PDC). This mitochondrial complex links glycolysis to the Krebs cycle and the current understanding of its regulation involves the cyclic phosphorylation and dephosphorylation by specific pyruvate dehydrogenase kinases (PDKs) and pyruvate dehydrogenase phosphatases (PDPs).
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Cites
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“These events induce a decrease of PDC activity.(30) Another scheme has been proposed in which an increase in the level of phosphorylation of Y94 of PDP1 could decrease the binding of lipoic acid on the E2 subunit and, thus, lead to a less active PDC.”
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Cited by
Metabolism of vascular smooth muscle cells in vascular diseases
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“phosphorylation and dysregulation of pyruvate dehydrogenase can be an important component 156 of the Warburg effect.(29) 157”
Metadata
- Authors
- Saunier, E., Benelli, C., & Bortoli, S.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2015-04-28
- Volume
- 138
- Issue
- 4
- Pages
- 809-817
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1949250268
- Cited by
- 219
- References
- 11
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Saunier, E., Benelli, C., & Bortoli, S. (2016). The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents. International Journal of Cancer. https://doi.org/10.1002/ijc.29564
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
