The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Nitrate in drinking water and colorectal cancer risk: A nationwide population‐based cohort study
Open accessAbstract
Nitrate in drinking water may increase risk of colorectal cancer due to endogenous transformation into carcinogenic N‐nitroso compounds. Epidemiological studies are few and often challenged by their limited ability of estimating long‐term exposure on a detailed individual level. We exploited population‐based health register data, linked in time and space with longitudinal drinking water quality data, on an individual level to study the association between long‐term drinking water nitrate exposure and colorectal cancer (CRC) risk. Individual nitrate exposure was calculated for 2.7 million adults based on drinking water quality analyses at public waterworks and private wells between 1978 and 2011. For the main analyses, 1.7 million individuals with highest exposure assessment quality were included. Follow‐up started at age 35. We identified 5,944 incident CRC cases during 23 million person‐years at risk. We used Cox proportional hazards models to estimate hazard ratios (HRs) of nitrate exposure on the risk of CRC, colon and rectal cancer. Persons exposed to the highest level of drinking water nitrate had an HR of 1.16 (95% CI: 1.08–1.25) for CRC compared with persons exposed to the lowest level. We found statistically significant increased risks at drinking water levels above 3.87 mg/L, well below the current drinking water standard of 50 mg/L. Our results add to the existing evidence suggesting increased CRC risk at drinking water nitrate concentrations below the current drinking water standard. A discussion on the adequacy of the drinking water standard in regards to chronic effects is warranted.
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Workgroup Report: Drinking-Water Nitrate and Health—Recent Findings and Research Needs
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Municipal Drinking Water Nitrate Level and Cancer Risk in Older Women: The Iowa Women’s Health Study
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Nitrate in Public Water Supplies and the Risk of Colon and Rectum Cancers
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Cited by
Drinking Water Nitrate and Human Health: An Updated Review
Ward, M., Jones, R., Brender, J., De Kok, T., Weyer, P., Nolan, B., Villanueva, C., & Van Breda, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15071557 · Cited by 1,576
Niu, H., Zhang, Z., Wang, X., Wan, X., Shao, C., & Guo, Y. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202008533 · Cited by 538
Quality Unknown: The Invisible Water Crisis
Damania, R., Desbureaux, S., Rodella, A.-S., Russ, J., & Zaveri, E. (2019) · World Bank, Washington, DC eBooks · doi:10.1596/978-1-4648-1459-4 · Cited by 284
Chazelas, E., Pierre, F., Druesne-Pecollo, N., Esseddik, Y., Szabo de Edelenyi, F., Agaesse, C., De Sa, A., Lutchia, R., Gigandet, S., Srour, B., et al. (2022) · International Journal of Epidemiology · doi:10.1093/ije/dyac046 · Cited by 135
Metadata
- Authors
- Schullehner, J., Hansen, B., Thygesen, M., Pedersen, C. B., & Sigsgaard, T.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2018-02-23
- Volume
- 143
- Issue
- 1
- Pages
- 73-79
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2793240808
- Cited by
- 375
- References
- 19
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- gold
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- Schullehner, J., Hansen, B., Thygesen, M., Pedersen, C. B., & Sigsgaard, T. (2018). Nitrate in drinking water and colorectal cancer risk: A nationwide population‐based cohort study. International Journal of Cancer. https://doi.org/10.1002/ijc.31306
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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