Iminosugars as Immunomodulating Agents: Synthesis and Biological Activities of 1‐Deoxynojirimycin and Related Compounds
Abstract
Iminosugars are an extremely interesting and versatile class of compounds and have many potential therapeutic applications. However, the use of iminosugar derivatives as immunomodulating agents is an area that is less explored. This review describes recent advances in the field of iminosugars as immunomodulating agents with a particular emphasis on 1‐deoxynojirimycin analogues and related compounds. Both chemical and biological aspects concerning their preparation and/or occurrence in nature, as well as their immunomodulatory properties, are discussed.
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Several data indicate the improving effect of iminosugars on EAE.
“but several data indicate the improving effect of iminosugars on EAE [451,452,453].”
From GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review (2022) · cites this paper as [451]
Cites
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De Masi, R., & Orlando, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137373 · Cited by 20 · see citing works
- Authors
- Li, Q., & Ye, X.
- Affiliations
- Peking University (CN)
- Corresponding author
- Ye, Xin‐Shan
- Venue
- Israel Journal of Chemistry
- Publisher
- Wiley
- Published
- 2015-03-06
- Volume
- 55
- Issue
- 3-4
- Pages
- 336-346
- ISSN
- 0021-2148 (ISSN-L)
- 1869-5868
- OpenAlex
- W1826566603
- Cited by
- 28
- References
- 4
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 4
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Israel Journal of Chemistry (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Keywords
- iminosugars, immunomodulation, 1-deoxynojirimycin, natural products, biological activity
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