Polyhydroxylated alkaloids—Natural occurrence and therapeutic applications
Abstract
Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and are arousing great interest as tools to study cellular recognition and as potential therapeutic agents. However, only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds.
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Swainsonine and castanospermine are iminosugar alkaloid glycosidases inhibitors, which also express anticancer properties and act on the protein-folding machinery.
“Swainsonine (mannose analogue) and castanospermine (glucose analogue) are iminosugar alkaloid glycosidases inhibitors, which also express anticancer properties and act on the protein-folding machinery [248].”
From GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review (2022) · cites this paper as [248]
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Looking-Glass Synergistic Pharmacological Chaperones: DGJ and L-DGJ from the Enantiomers of Tagatose
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Steviamine, a new indolizidine alkaloid from Stevia rebaudiana
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- Authors
- Watson, A. A., Fleet, G. W. J., Asano, N., Molyneux, R. J., & Nash, R. J.
- Affiliations
- University of Oxford (GB)
- Hokuriku University (JP)
- Western Regional Research Center (US)
- Aberystwyth University (GB)
- Corresponding author
- Nash, Robert J.
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 56
- Issue
- 3
- Pages
- 265-295
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W2085285145
- Cited by
- 714
- References
- 239
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 17 · 2023: 12 · 2022: 20 · 2021: 21 · 2020: 25 · 2019: 28 · 2018: 20 · 2017: 18 · 2016: 33 · 2015: 29 · 2014: 51 · 2013: 49 · 2012: 41
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Keywords
- polyhydroxylated alkaloids, natural products, glycosidase inhibitors, plant alkaloids, cellular recognition, therapeutic applications, natural product isolation
- MeSH terms
- Alkaloids, Animals, Enzyme Inhibitors, Glycoside Hydrolases, Toxicity Tests
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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