Cited by 732Alkaloids: synthesis and pharmacologyPhytochemistry and Biological ActivitiesCarbohydrate Chemistry and Synthesis

Polyhydroxylated alkaloids—Natural occurrence and therapeutic applications

Watson, Alison A., Fleet, George W.J., Asano, Naoki, Molyneux, Russell J., Nash, Robert J.·2001·Phytochemistry

Abstract

Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and are arousing great interest as tools to study cellular recognition and as potential therapeutic agents. However, only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds.

Integrity signals

Registry

Crossref · 10.1016/s0031-9422(00)00451-9

Cites

233 of 233 references verified0 citation errors · 0 not checkable

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Authors
Watson, A. A., Fleet, G. W. J., Asano, N., Molyneux, R. J., & Nash, R. J.
Affiliations
  • University of Oxford (GB)
  • Hokuriku University (JP)
  • Western Regional Research Center (US)
  • Aberystwyth University (GB)
Corresponding author
Nash, Robert J.
Venue
Phytochemistry
Publisher
Elsevier BV
Published
2001-02
Volume
56
Issue
3
Pages
265-295
ISSN
0031-9422 (ISSN-L)
OpenAlex
W2085285145
Cited by
714
References
239
Citations by year
2026: 10 · 2025: 10 · 2024: 17 · 2023: 12 · 2022: 20 · 2021: 21 · 2020: 25 · 2019: 28 · 2018: 20 · 2017: 18 · 2016: 33 · 2015: 29 · 2014: 51 · 2013: 49 · 2012: 41
FWCI
2.11
Type
journal article
Language
en
Open access
closed
Locations
  • Phytochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
Keywords
polyhydroxylated alkaloids, natural products, glycosidase inhibitors, plant alkaloids, cellular recognition, therapeutic applications, natural product isolation
MeSH terms
Alkaloids, Animals, Enzyme Inhibitors, Glycoside Hydrolases, Toxicity Tests

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