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Translational control by cytoplasmic polyadenylation of c‐mos mRNA is necessary for oocyte maturation in the mouse.
Open accessAbstract
The c-mos proto-oncogene product is a key element in the cascade of events leading to meiotic maturation of vertebrate oocytes. We have investigated the role of cytoplasmic polyadenylation in the translational control of mouse c-mos mRNA and its contribution to meiosis. Using an RNase protection assay we show that optimal cytoplasmic polyadenylation of c-mos mRNA requires three cis elements in the 3' UTR: the polyadenylation hexanucleotide AAUAAA and two U-rich cytoplasmic polyadenylation elements (CPEs) located 4 and 51 nucleotides upstream of the hexanucleotide. When fused to CAT coding sequences, the wild-type 3' UTR of c-mos mRNA, but not a 3' UTR containing mutations in both CPEs, confers translational recruitment during maturation. This recruitment coincides with maximum polyadenylation. To assess whether c-mos mRNA polyadenylation is necessary for maturation of mouse oocytes, we have ablated endogenous c-mos mRNA by injecting an antisense oligonucleotide, which results in a failure to progress to meiosis II after emission of the first polar body. Such antisense oligonucleotide-injected oocytes could be efficiently rescued by co-injection of a c-mos mRNA carrying a wild-type 3' UTR. However, co-injection of a c-mos mRNA lacking functional CPEs substantially lowered the rescue activity. These results demonstrate that translational control of c-mos mRNA by cytoplasmic polyadenylation is necessary for normal development.
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“We favor this last possibility because it agrees with the known importance of cytoplasmic polyadenylation for activating genes in maturing oocytes8,21,22 and early embryos23,24 of Xenopus and certain other vertebrate contexts25–30.”
From Poly(A)-tail profiling reveals an embryonic switch in translational control (2014) · cites this paper as [26]
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Metadata
- Authors
- Gebauer, F., Xu, W., Cooper, G. M., & Richter, J. D.
- Venue
- The EMBO Journal
- Published
- 1994-12-01
- Volume
- 13
- Issue
- 23
- Pages
- 5712-5720
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC395537
- OpenAlex
- W126837237
- Cited by
- 235
- References
- 58
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 5
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- March of Dimes Foundation
- National Institutes of Health (7r01ca040189-14, 5r01hd026594-09)
- National Cancer Institute (CA-40189)
- National Institute of General Medical Sciences (GM46779, R01GM046779)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD26594)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- c-mos, cytoplasmic polyadenylation, oocyte maturation, translational regulation, 3' untranslated region, cytoplasmic polyadenylation element, meiotic maturation, antisense oligonucleotides, mouse oocytes, meiosis II
- MeSH terms
- Adenosine Monophosphate, Amino Acid Sequence, Animals, Base Sequence, Cytoplasm, Kinetics, Meiosis, Molecular Sequence Data, Oogenesis, RNA, Messenger, Protein Biosynthesis, Proto-Oncogene Proteins c-mos, Mice
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