The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus.
Open accessAbstract
Very little is known about the mechanism of cell entry of hepatitis A virus (HAV), and the identification of cellular receptors for this picornavirus has been elusive. Here we describe the molecular cloning of a cellular receptor for HAV using protective monoclonal antibodies raised against susceptible African green monkey kidney (AGMK) cells as probes. Monoclonal antibodies 190/4, 235/4 and 263/6, which reacted against similar epitopes, specifically protected AGMK cells against HAV infection by blocking the binding of HAV. Expression cloning and nucleotide sequence analysis of the cDNA coding for epitope 190/4 revealed a novel mucin-like class I integral membrane glycoprotein of 451 amino acids, the HAV cellular receptor 1 (HAVcr-1). Immunofluorescence analysis indicated that mouse Ltk- cells transfected with HAVcr-1 cDNA gained limited susceptibility to HAV infection, which was blocked by treatment with monoclonal antibody 190/4. Our results demonstrate that the HAVcr-1 polypeptide is an attachment receptor for HAV and strongly suggest that it is also a functional receptor which mediates HAV infection. This report constitutes the first identification of a cellular receptor for HAV.
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Metadata
- Authors
- Kaplan, G., Totsuka, A., Thompson, P., Akatsuka, T., Moritsugu, Y., & Feinstone, S. M.
- Venue
- The EMBO Journal
- Published
- 1996-08
- Volume
- 15
- Issue
- 16
- Pages
- 4282-4296
- ISSN
- 0261-4189 (ISSN-L)
- OpenAlex
- W2128847715
- Cited by
- 286
- References
- 35
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kaplan, G., Totsuka, A., Thompson, P., Akatsuka, T., Moritsugu, Y., & Feinstone, S. M. (1996). Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus. The EMBO Journal. https://doi.org/10.1002/j.1460-2075.1996.tb00803.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
