The TIM gene family: emerging roles in immunity and disease

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Pathogenic implications of iron accumulation in multiple sclerosis

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TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells

Nakae, S., Iikura, M., Suto, H., Akiba, H., Umetsu, D. T., DeKruyff, R. H., Saito, H., & Galli, S. J. (2007) · Blood · doi:10.1182/blood-2006-11-058800 · Cited by 169 · see citing works

Diverse roles for semaphorin−plexin signaling in the immune system

Takamatsu, H., & Kumanogoh, A. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.01.008 · Cited by 167 · see citing works

Inhibitory Receptors on Lymphocytes: Insights from Infections

Odorizzi, P. M., & Wherry, E. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1100038 · Cited by 167 · see citing works

Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family

Santiago, C. A., Ballesteros, Á., Tami, C., Martínez‐Muñoz, L., Kaplan, G. G., & Casasnovas, J. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.01.014 · Cited by 164 · see citing works

Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion

Huang, X., Bai, X., Cao, Y., Wu, J., Huang, M., Tang, D., Tao, S., Zhu, T., Liu, Y., Yang, Y., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20090397 · Cited by 156 · see citing works

Do Mouse Models of Allergic Asthma Mimic Clinical Disease?

Epstein, M. M. (2004) · International Archives of Allergy and Immunology · doi:10.1159/000076131 · Cited by 158 · see citing works

NKp44 Receptor Mediates Interaction of the Envelope Glycoproteins from the West Nile and Dengue Viruses with NK Cells

Hershkovitz, O., Rosental, B., Rosenberg, L. A., Sanchez, M. E. N., Jivov, S., Zilka, A., Gershoni‐Yahalom, O., Brient‐Litzler, E., Bedouelle, H., Ho, J. W. Y., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802806 · Cited by 150 · see citing works

A Reappraisal of Humoral Immunity Based on Mechanisms of Antibody‐Mediated Protection Against Intracellular Pathogens

Casadevall, A., & Pirofski, L. (2006) · Advances in immunology · doi:10.1016/s0065-2776(06)91001-3 · Cited by 146 · see citing works

Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice

Xiao, S., Brooks, C. R., Zhu, C. Y., Wu, C., Sweere, J. M., Petecka, S., Yeste, A., Quintana, F. J., Ichimura, T., Sobel, R. A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120914109 · Cited by 143 · see citing works

Infections and Autoimmunity—Good or Bad?

Christen, U., & von Herrath, M. G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7481 · Cited by 142 · see citing works

Shedding of the Urinary Biomarker Kidney Injury Molecule-1 (KIM-1) Is Regulated by MAP Kinases and Juxtamembrane Region

Zhang, Z., Humphreys, B. D., & Bonventre, J. V. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007030325 · Cited by 142 · see citing works

T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response

Yang, X., Jiang, X., Chen, G., Xiao, Y., Geng, S., Kang, C., Zhou, T., Li, Y., Guo, X., He, X., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202661 · Cited by 138 · see citing works

The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses

Crawford, A., & Wherry, E. J. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.010 · Cited by 134 · see citing works

Tim-3 expression and its role in hepatocellular carcinoma

Liu, F., Liu, Y., & Chen, Z. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0667-4 · Cited by 136 · see citing works

Soluble Form of T Cell Ig Mucin 3 Is an Inhibitory Molecule in T Cell-Mediated Immune Response

Geng, H., Zhang, G., Li, D., Zhang, H., Yuan, Y., Zhu, H.-G., Han, X., Han, L., & Feng, Z. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1411 · Cited by 134 · see citing works

Cutting Edge: T Cell Ig Mucin-3 Reduces Inflammatory Heart Disease by Increasing CTLA-4 during Innate Immunity

Frisancho‐Kiss, S., Nyland, J. F., Davis, S. E., Barrett, M. A., Gatewood, S. J. L., Njoku, D. B., Čiháková, D., Silbergeld, E. K., Rose, N. R., & Fairweather, D. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6411 · Cited by 132 · see citing works

New roles for TIM family members in immune regulation

Kuchroo, V. K., Dardalhon, V., Xiao, S., & Anderson, A. C. (2008) · Nature reviews. Immunology · doi:10.1038/nri2366 · Cited by 132 · see citing works

TIM-1, a novel allergy and asthma susceptibility gene

McIntire, J. J., Umetsu, D. T., & DeKruyff, R. H. (2004) · Springer Seminars in Immunopathology · doi:10.1007/s00281-003-0141-3 · Cited by 128 · see citing works

Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function

Xiao, S., Najafian, N., Reddy, J., Albin, M., Zhu, C. Y., Jensen, E., Imitola, J., Korn, T., Anderson, A. C., Zhang, Z., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062498 · Cited by 128 · see citing works

Immunostimulatory Tim-1–specific antibody deprograms Tregs and prevents transplant tolerance in mice

Degauque, N., Mariat, C., Kenny, J. J., Zhang, D., Gao, W., Vu, M. D., Alexopoulos, S. P., Oukka, M., Umetsu, D. T., DeKruyff, R. H., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32562 · Cited by 126 · see citing works

Tim-2 regulates T helper type 2 responses and autoimmunity

Chakravarti, S., Sabatos, C. A., Xiao, S., Illés, Z., Cha, E. K., Sobel, R. A., Zheng, X. X., Strom, T. B., & Kuchroo, V. K. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050308 · Cited by 125 · see citing works

TIM-3 Regulates Distinct Functions in Macrophages

Ocaña‐Guzmán, R., Torre-Bouscoulet, L. I., & Sada‐Ovalle, I. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00229 · Cited by 121 · see citing works

T-Cell Immunoglobulin Mucin-3 Determines Severity of Liver Ischemia/Reperfusion Injury in Mice in a TLR4-Dependent Manner

Uchida, Y., Ke, B., Freitas, M. C. S., Yagita∥, H., Akiba, H., Busuttil, R. W., Najafian, N., & Kupiec‐Weglinski, J. W. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.07.003 · Cited by 119 · see citing works

Preferential Involvement of Tim-3 in the Regulation of Hepatic CD8+ T Cells in Murine Acute Graft-versus-Host Disease

Oikawa, T., Kamimura, Y., Akiba, H., Yagita∥, H., Okumura, K., Takahashi, H., Zeniya, M., Tajiri, H., & Azuma, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4281 · Cited by 114 · see citing works

Biomarkers for PD-1/PD-L1 Blockade Therapy in Non–Small-cell Lung Cancer: Is PD-L1 Expression a Good Marker for Patient Selection?

Chae, Y. K., Pan, A. P., Davis, A. A., Raparia, K., Mohindra, N. A., Matsangou, M., & Giles, F. J. (2016) · Clinical Lung Cancer · doi:10.1016/j.cllc.2016.03.011 · Cited by 113 · see citing works

Immunoglobulin superfamily receptors in protochordates: before RAG time

Pasquier, L. D., Zucchetti, I., & Santis, R. D. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00122.x · Cited by 113 · see citing works

Validation of putative genomic biomarkers of nephrotoxicity in rats

Wang, E., Snyder, R. D., Fielden, M. R., Smith, R. J., & Gu, Y. (2008) · Toxicology · doi:10.1016/j.tox.2007.12.031 · Cited by 111 · see citing works

Kidney Injury Molecule 1 (KIM-1): a Multifunctional Glycoprotein and Biological Marker (Review)

Анатольевна, К. Т., Sergeeva, N. S., Kanukoev, K. Y., Alekseev, B. Y., & Каприн, А. Д. (2021) · Современные технологии в медицине · doi:10.17691/stm2021.13.3.08 · Cited by 111 · see citing works

TIM Family of Genes in Immunity and Tolerance

Kuchroo, V. K., Meyers, J. H., Umetsu, D. T., & DeKruyff, R. H. (2006) · Advances in immunology · doi:10.1016/s0065-2776(06)91006-2 · Cited by 111 · see citing works

Cellular and mitochondrial iron homeostasis in vertebrates

Chen, C., & Paw, B. H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.01.003 · Cited by 106 · see citing works

Molecular signatures of T-cell inhibition in HIV-1 infection

Larsson, M., Shankar, E. M., Che, K. F., Saeidi, A., Ellegård, R., Barathan, M., Velu, V., & Kamarulzaman, A. (2013) · Retrovirology · doi:10.1186/1742-4690-10-31 · Cited by 108 · see citing works

TIM-4 Expressed on APCs Induces T Cell Expansion and Survival

Rodriguez‐Manzanet, R., Meyers, J. H., Balasubramanian, S., Slavik, J. M., Kassam, N., Dardalhon, V., Greenfield, E. A., Anderson, A. C., Sobel, R. A., Hafler, D. A., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4706 · Cited by 107 · see citing works

The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model

Ueno, T., Habicht, A., Clarkson, M. R., Albin, M. J., Yamaura, K., Boenisch, O., Popoola, J., Wang, Y., Yagita∥, H., Akiba, H., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32451 · Cited by 104 · see citing works

Regulation of immune cell responses by semaphorins and their receptors

Takamatsu, H., Okuno, T., & Kumanogoh, A. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2009.111 · Cited by 104 · see citing works

Tim-3 Negatively Regulates IL-12 Expression by Monocytes in HCV Infection

Zhang, Y., Cheng, J., Wang, J. M., Xiao, J., Wu, X. Y., Jia, Z., Moorman, J. P., & Yao, Z. Q. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019664 · Cited by 100 · see citing works

Th1/Th2 cells in inflammatory disease states: therapeutic implications

Moss, R. B., Moll, T., El-Kalay, M., Kohne, C., Hoo, W. S., Encinas, J. A., & Carlo, D. J. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.12.1887 · Cited by 96 · see citing works

Tim-3-Expressing CD4+ and CD8+ T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector Functions

Qiu, Y., Chen, J., Liao, H., Zhang, Y., Wang, H., Li, S., Luo, Y., Fang, D., Li, G., Zhou, B., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002984 · Cited by 94 · see citing works

Sequence, structure, function, immunity: structural genomics of costimulation

Chattopadhyay, K., Lázár‐Molnár, E., Yan, Q., Rubinstein, R., Zhan, C., Vigdorovich, V. I., Ramagopal, U. A., Bonanno, J. B., Nathenson, S. G., & Almo, S. C. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00778.x · Cited by 94 · see citing works

Iron Uptake Mediated by Binding of H-Ferritin to the TIM-2 Receptor in Mouse Cells

Han, J., Seaman, W. E., Di, X., Wang, W., Willingham, M. C., Torti, F. M., & Torti, S. V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023800 · Cited by 93 · see citing works

TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury

Yamanishi, Y., Kitaura, J., Izawa, K., Kaitani, A., Komeno, Y., Nakamura, M., Yamazaki, S., Enomoto, Y., Oki, T., Akiba, H., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20090581 · Cited by 92 · see citing works

T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword

Simons, K. H., de Jong, A., Jukema, J. W., de Vries, M. R., Arens, R., & Quax, P. H. A. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0164-7 · Cited by 88 · see citing works

Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain—IL-2–inducible T-cell kinase gene cluster in chromosome 5q33

Graves, P. E., Siroux, V., Guerra, S., Klimecki, W. T., & Martínez, F. D. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.05.004 · Cited by 88 · see citing works

Costimulatory pathways in transplantation

Pilat, N., Sayegh, M. H., & Wekerle, T. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.04.002 · Cited by 86 · see citing works

TIM-family proteins inhibit HIV-1 release

Li, M., Ablan, S. D., Miao, C., Zheng, Y.-M., Fuller, M. S., Rennert, P. D., Maury, W. J., Johnson, M. C., Freed, E. O., & Liu, S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404851111 · Cited by 86 · see citing works

TH2 adjuvants: Implications for food allergy

Berin, M. C., & Shreffler, W. G. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.04.023 · Cited by 81 · see citing works

TIM-1 Mediates Dystroglycan-Independent Entry of Lassa Virus

Brouillette, R. B., Phillips, E. K., Patel, R. J., Mahauad‐Fernandez, W. D., Møller-Tank, S., Rogers, K. J., Dillard, J. A., Cooney, A. L., Martínez‐Sobrido, L., Okeoma, C. M., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00093-18 · Cited by 80 · see citing works

Initiation of autoimmunity

Christen, U., & von Herrath, M. G. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.09.002 · Cited by 79 · see citing works

The Role of Biomarkers in the Diagnosis and Risk Stratification of Acute Graft-versus-Host Disease: A Systematic Review

Ali, A. M., DiPersio, J. F., & Schroeder, M. A. (2016) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2016.04.022 · Cited by 78 · see citing works

Host controls of HIV broadly neutralizing antibody development

Kelsoe, G. H., & Haynes, B. F. (2017) · Immunological Reviews · doi:10.1111/imr.12508 · Cited by 77 · see citing works

The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis

Chae, S., Park, Y., Shim, S. C., Yoon, K., & Chung, H. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.06.008 · Cited by 77 · see citing works

Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives

Raimondo, S., Pucci, M., Alessandro, R., & Fontana, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072286 · Cited by 76 · see citing works

Expression of Human TIM‐1 and TIM‐3 on Lymphocytes from Systemic Lupus Erythematosus Patients

Wang, Y., Meng, J., Wang, X., Liu, S., Shu, Q., Gao, L., Ju, Y., zhang, L., Sun, W., & Ma, C. (2007) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2007.02038.x · Cited by 76 · see citing works

Atopic diseases of childhood

Stone, K. D. (2003) · Current Opinion in Pediatrics · doi:10.1097/00008480-200310000-00009 · Cited by 75 · see citing works

Cysteine tagging for MS‐based proteomics

Giron, P., Dayon, L., & Sanchez, J. (2010) · Mass Spectrometry Reviews · doi:10.1002/mas.20285 · Cited by 74 · see citing works

TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity

Angiari, S., Donnarumma, T., Rossi, B., Dusi, S., Pietronigro, E. C., Zenaro, E., Bianca, V. D., Toffali, L., Piacentino, G., Budui, S. L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.004 · Cited by 73 · see citing works

Fragile TIM-4–expressing tissue resident macrophages are migratory and immunoregulatory

Thornley, T. B., Fang, Z., Balasubramanian, S., Larocca, R. A., Gong, W., Gupta, S., Csizmadia, E., Degauque, N., Kim, B. S., Koulmanda, M., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73527 · Cited by 74 · see citing works

Physicochemical Characterization of Liposomes That Mimic the Lipid Composition of Exosomes for Effective Intracellular Trafficking

Sakai‐Kato, K., Yoshida, K., Takechi‐Haraya, Y., & Izutsu, K. (2020) · Langmuir · doi:10.1021/acs.langmuir.0c02491 · Cited by 73 · see citing works

TIM-1 and TIM-3 proteins in immune regulation

Su, E. W., Lin, J., & Kane, L. (2008) · Cytokine · doi:10.1016/j.cyto.2008.06.013 · Cited by 73 · see citing works

Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population

Gao, P.-S., Mathias, R. A., Plunkett, B., Togias, A. G., Barnes, K. C., Beaty, T. H., & Huang, S.-K. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.01.035 · Cited by 72 · see citing works

Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells

Sims, B., Farrow, A. L., Williams, S. D., Bansal, A., Krendelchtchikov, A., Gu, L., & Matthews, Q. L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s132762 · Cited by 70 · see citing works

IP-10 and Type 1 Diabetes: A Question of Time and Location

Christen, U., & von Herrath, M. G. (2004) · Autoimmunity · doi:10.1080/08916930410001713124 · Cited by 70 · see citing works

Tim-3 is upregulated in human colorectal carcinoma and associated with tumor progression

Yu, M., Bin, L., Liu, Y., Me, Y., Wang, L., & Zhang, P. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.6065 · Cited by 69 · see citing works

Semaphorin4A and H‐ferritin utilize Tim‐1 on human oligodendrocytes: A novel neuro‐immune axis

Chiou, B., Lucassen, E. B., Sather, M. D., Kallianpur, A. R., & Connor, J. R. (2018) · Glia · doi:10.1002/glia.23313 · Cited by 68 · see citing works

The emerging role of T cell immunoglobulin mucin‐1 in the mechanism of liver ischemia and reperfusion injury in the mouse†

Uchida, Y., Ke, B., Freitas, M. C. S., Ji, H., Zhao, D., Benjamin, E., Najafian, N., Yagita∥, H., Akiba, H., Busuttil, R. W., et al. (2009) · Hepatology · doi:10.1002/hep.23442 · Cited by 68 · see citing works

Relationship between the TIM Gene Family and with Autoimmune and Allergic Diseases

Wu, J. (2006) · Yixue fenzi shengwuxue zazhi

TIM Family of Genes in Immunity and Tolerance

Kuchroo, V. K., Meyers, J. H., Umetsu, D. T., & DeKruyff, R. H. (2006) · Advances in immunology · doi:10.1016/s0065-2776(06)91006-2 · Cited by 111 · see citing works

The TIM gene family regulates autoimmune and allergic diseases

Meyers, J. H., Sabatos, C. A., Chakravarti, S., & Kuchroo, V. K. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.06.008 · Cited by 216 · see citing works

Role of TIM family members in immune regulation:recent progress

Fu, Z. (2010) · Academic Journal of Second Military Medical University

TIM family proteins and autoimmunity

Kane, L. (2007) · Autoimmunity · doi:10.1080/08916930701464871 · Cited by 7 · see citing works