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Fungal fimbriae are composed of collagen
Open accessAbstract
Fungal fimbriae are surface appendages that were first described on the haploid cells of the smut fungus, Microbotryum violaceum. They are long (1-20 microm), narrow (7 nm) flexuous structures that have been implicated in cellular functions such as mating and pathogenesis. Since the initial description, numerous fungi from all five phyla have been shown to produce fimbriae on their extracellular surfaces. The present study analyses the protein component of M.violaceum fimbriae. The N-terminus and three internal amino acid sequences were determined. All four show a strong similarity to sequences which are characteristic of the collagen gene family. Enzymatic digests and immunochemical analyses support this finding. Based on these results, it is suggested that the proteinaceous subunits of fimbriae should be termed fungal collagens. Previously, collagen has been found only among members of the kingdom Animalia where it is the principal component of the animal extracellular matrix and is the most abundant animal protein. The unexpected finding of collagen in the members of the Mycota suggests that it may have evolved from a common ancestor that existed before the divergence of fungi and animals. Further, native fungal fimbriae can function as a mammalian extracellular matrix component. They can act as a substratum which permits animal cells to adhere, spread, and proliferate in a manner similar to animal collagens. The implications of this finding to both phylogeny and pathology are discussed.
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“Given that fungi can produce collagen (Celerin et al., 1996), the need to rule out exogenous sources of organics in fossil bone is made all the greater.”
From Cretaceous dinosaur bone contains recent organic material and provides an environment conducive to microbial communities (2019) · cites this paper as Celerin et al., 1996
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Metadata
- Authors
- Celerin, M., Ray, J. M., Schisler, N. J., Day, A. W., Stetler‐Stevenson, W. G., & Laudenbach, D. E.
- Affiliations
- Western University (CA)
- Venue
- The EMBO Journal
- Published
- 1996-09-01
- Volume
- 15
- Issue
- 17
- Pages
- 4445-4453
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC452173
- OpenAlex
- W4299502632
- Semantic Scholar
- 5e02d77019b756ef1e24f6259e8d52f6fc50c28e
- Cited by
- 126
- References
- 28
- Citations by year
- 2022: 3 · 2021: 3 · 2020: 2 · 2019: 8 · 2018: 2 · 2017: 2 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Microbotryum violaceum, smut fungi, extracellular matrix, protein sequence analysis, fungal evolution, cell adhesion, fungal pathogenesis, mating
- MeSH terms
- Amino Acid Sequence, Amino Acids, Cell Adhesion, Cell Membrane, Collagen, Fungal Proteins, Humans, Immunohistochemistry, Molecular Sequence Data, Tumor Cells, Cultured, Ustilago, Collagenases
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