Food Intake in Prader‐Willi Syndrome and Controls with Obesity After Administration of a Benzodiazepine Receptor Agonist
Open accessAbstract
Benzodiazepine receptor (BZR) agonists, used extensively for their anxiolytic effects, have been shown to increase food intake in many mammalian species. Little information, however, is available on the effects of BZR agonists on feeding behaviors of humans. Food intake was evaluated in a 60‐minute free‐feeding standardized test after the acute administration of the BZR agonist chlordiazepoxide (CDP, Librium; 5 mg or 20 mg) or placebo. Subjects were 12 individuals with the Prader Willi syndrome (PWS), a disorder characterized by extreme hyperphagia and morbid obesity, and 11 controls with obesity. PWS subjects showed the characteristic hyperphagia associated with the appetite disorder, consuming more than six times as many sandwiches as controls with obesity. Results revealed no significant effect of either dose of CDP on the food intake of either group. Serum assays revealed that dose‐dependent, clinically effective levels of CDP and active metabolites were achieved. These results suggest that acute administration of the BZR agonist CDP, at the therapeutic levels used, may not increase food intake in populations with obesity. However, the chronic effects of CDP on appetite in human populations still need to be explored.
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If given access, individuals with PWS will consume three to six times as much food as individuals without the syndrome, and show delayed meal termination, and earlier return of hunger after a previous meal.
“If given access, individuals with PWS will consume three to six times as much food as individuals without the syndrome, and show delayed meal termination, and earlier return of hunger after a previous meal [673,674].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [673]
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Cites
Goodman & Gilman's The Pharmacological Basis of Therapeutics
Brunton, L. L. (1985) · Cited by 7,321 · see citing works
Prader-Willi Syndrome: Consensus Diagnostic Criteria
Holm, V. A., Cassidy, S. B., Butler, M. G., Hanchett, J. M., Greenswag, L. R., Whitman, B. Y., & Greenberg, F. (1993) · Pediatrics · doi:10.1542/peds.91.2.398 · Cited by 1,278 · see citing works
Genetic imprinting suggested by maternal heterodisomy in non-deletion Prader-Willi syndrome
Nicholls, R. D., Knoll, J. H. M., Butler, M. G., Karam, S., & Lalande, M. (1989) · Nature · doi:10.1038/342281a0 · Cited by 878 · see citing works
Deletions of Chromosome 15 as a Cause of the Prader–Willi Syndrome
Ledbetter, D. H., Riccardi, V. M., Airhart, S. D., Strobel, R. J., Keenan, B. S., & Crawford, J. D. (1981) · New England Journal of Medicine · doi:10.1056/nejm198102053040604 · Cited by 622 · see citing works
Prader, A. (1956) · Medical Entomology and Zoology · Cited by 619 · see citing works
Knoll, J. H. M., Nicholls, R. D., Magenis, R. E., Graham, J. M., Lalande, M., Latt, S. A., Opitz, J. M., & Reynolds, J. F. (1989) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320320235 · Cited by 576 · see citing works
Clinical and cytogenetic survey of 39 individuals with Prader‐Labhart‐Willi syndrome
Butler, M. G., Meaney, F. J., Palmer, C. G., Opitz, J. M., & Reynolds, J. F. (1986) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320230307 · Cited by 316 · see citing works
Özçelık, T., Leff, S. E., Robinson, W. P., Donlon, T. A., Lalande, M., Sanjines, E. M., Schinzel, A., & Francke, U. (1992) · Nature Genetics · doi:10.1038/ng1292-265 · Cited by 279 · see citing works
Reis, A., Dittrich, B., Greger, V., Buiting, K., Lalande, M., Gillessen‐Kaesbach, G., Anvret, M., & Horsthemke, B. (1994) · PubMed Central · Cited by 221 · see citing works
Dittrich, B., Robinson, W., Knoblauch, H., Buiting, K., Schmidt, K., Gillessen‐Kaesbach, G., & Horsthemke, B. (1992) · Human Genetics · doi:10.1007/bf00220089 · Cited by 200 · see citing works
Magenis, R. E., Toth‐Fejel, S., Allen, L., Black, M. H., Brown, M. G., Budden, S. S., Cohen, R., Friedman, J. M., Kalousek, D. K., Zonana, J., et al. (1990) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320350307 · Cited by 198 · see citing works
Benzodiazepines as appetite-enhancing compounds
Cooper, S. J. (1980) · Appetite · doi:10.1016/s0195-6663(80)80005-5 · Cited by 179 · see citing works
Pancreatic polypeptide infusions reduce food intake in Prader-Willi syndrome
Berntson, G. G., Zipf, W. B., O’Dorisio, T. M., Hoffman, J. A., & Chance, R. E. (1993) · Peptides · doi:10.1016/0196-9781(93)90138-7 · Cited by 137 · see citing works
Self-citationZipf, W. B., & Berntson, G. G. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/46.2.277 · Cited by 74 · see citing works
Self-citationCooper, S. J., Barber, D. J., Gilbert, D. B., & Moores, W. R. (1985) · Psychopharmacology · doi:10.1007/bf00432227 · Cited by 72 · see citing works
Cole, S. W. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(83)90456-2 · Cited by 39 · see citing works
Foltin, R. W., Ellis, S., & Schuster, C. R. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90565-9 · Cited by 39 · see citing works
Midazolam-induced hyperphagia and FG 7142-induced anorexia: Behavioural characteristics in the rat
Cooper, S. J., & Yerbury, R. E. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90237-6 · Cited by 38 · see citing works
Cooper, S. J. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb53253.x · Cited by 37 · see citing works
Cooper, S. J., & Moores, W. R. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90236-5 · Cited by 36 · see citing works
Anxiolytic actions of chlordiazepoxide determine its effects on hyponeophagia in rats
Shephard, R. A., & Estall, L. B. (1984) · Psychopharmacology · doi:10.1007/bf00427683 · Cited by 35 · see citing works
Yerbury, R. E., & Cooper, S. J. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90500-4 · Cited by 32 · see citing works
Short-term infusion of pancreatic polypeptide: effect on children with Prader-Willi syndrome
Zipf, W. B., O’Dorisio, T. M., & Berntson, G. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/51.2.162 · Cited by 29 · see citing works
Self-citationBi-directional changes in sham feeding in the rat produced by benzodiazepine receptor ligands
Cooper, S. J., van der Hoek, G. A., & Kirkham, T. C. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90072-8 · Cited by 24 · see citing works
Chlordiazepoxide-induced selection of saccharin-flavoured food in the food-deprived rat
Cooper, S. J. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90308-8 · Cited by 20 · see citing works
Bidirectional changes in the consumption of food produced by β-carbolines
Cooper, S. J. (1987) · Brain Research Bulletin · doi:10.1016/0361-9230(87)90103-1 · Cited by 20 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Soubrie P, eds. Animal Models of Psychiatric Disorders (3). Switzerland: Basel, Switzerland: S . Karger: 199 I ; 2 U .
- Cooper SJ, Yerbury RE. Midazolam-induced hyperphagia and FG7 142-induced anorexia: Behavioral characteristics in the rat. Pharmacol Biochem Behav. 1986;25:99-106.
- Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, eds. Goodman & Gilmun's The Pharmucological Basis of Therapeutics. 9th ed. New York: McGraw-Hill; I996;424.
- Yerbury RE, Cooper SJ. The benzodiazepine partial ago- nists, Ro 16-6028 and Ro 17-18 12, increase palatable food con- sumption in nondeprived rats. Pharmacol Biochem Behav. I987;28:427-43 1.
Cited by
Sorted by citations
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
SnoRNA Snord116 (Pwcr1/MBII-85) Deletion Causes Growth Deficiency and Hyperphagia in Mice
Ding, F., Li, H. H., Zhang, S., Solomon, N. M., Camper, S. A., Cohen, P., & Francke, U. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001709 · Cited by 290 · see citing works
Eating behavior in Prader-Willi syndrome, normal weight, and obese control groups
Lindgren, A. C., Barkeling, B., Hägg, A., Ritzén, E. M., Marcus, C., & Rössner, S. (2000) · The Journal of Pediatrics · doi:10.1067/mpd.2000.106563 · Cited by 139 · see citing works
Miller, J. L., James, G. A., Goldstone, A. P., Couch, J. A., He, G., Driscoll, D. J., & Liu, Y. (2007) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.099044 · Cited by 119 · see citing works
Development of the eating behaviour in Prader–Willi Syndrome: advances in our understanding
McAllister, C., Whittington, J. E., & Holland, A. J. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.139 · Cited by 96 · see citing works
Prader-Willi Syndrome: Clinical Aspects
Grechi, E., Cammarata, B., Mariani, B., Candia, S. D., & Chiumello, G. (2012) · Journal of Obesity · doi:10.1155/2012/473941 · Cited by 85 · see citing works
The hypothalamus, hormones, and hunger: alterations in human obesity and illness
Goldstone, A. P. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)53003-1 · Cited by 83 · see citing works
A Comprehensive Team Approach to the Management of Patients with Prader-Willi Syndrome
Eiholzer, U., & Whitman, B. Y. (2004) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2004.17.9.1153 · Cited by 66 · see citing works
Psychotropic treatments in Prader-Willi syndrome: a critical review of published literature
Bonnot, O., Cohen, D., Thuilleaux, D., Consoli, A., Çabal-Berthoumieu, S., & Tauber, M. (2015) · European Journal of Pediatrics · doi:10.1007/s00431-015-2670-x · Cited by 63 · see citing works
Prader–Willi syndrome: From genetics to behaviour, with special focus on appetite treatments
Griggs, J. L., Sinnayah, P., & Mathai, M. L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.003 · Cited by 45 · see citing works
Understanding the causes of obesity in children with trisomy 21: hyperphagia vs physical inactivity
Foerste, T., Sabin, M. A., Reid, S. M., & Reddihough, D. S. (2016) · Journal of Intellectual Disability Research · doi:10.1111/jir.12259 · Cited by 40 · see citing works
What can we learn from PWS and SNORD116 genes about the pathophysiology of addictive disorders?
Salles, J., Lacassagne, E., Eddiry, S., Franchitto, N., Salles, J., & Tauber, M. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00917-x · Cited by 36 · see citing works
GABAA receptors activate fish feeding behaviour via two distinct functional pathways
Snigirov, S. M., & Sylantyev, S. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.170514 · Cited by 17 · see citing works
Neurodevelopmental and Neuropsychological Aspects of Prader-Willi Syndrome
Whitman, B. Y., & Thompson, T. (2006) · Springer eBooks · doi:10.1007/978-0-387-33536-0_8 · Cited by 10 · see citing works
Multidimensional Characterisation of Eating Behaviour in Genetic Obesity: A Systematic Review
Guillon, E., Dubern, B., Clément, K., & Poitou, C. (2025) · Obesity Facts · doi:10.1159/000548535 · Cited by 6 · see citing works
Interdisciplinary Aspects of Childhood Obesity and Physical Fitness
Pařízková, J., Rovillé-Sausse, F., & Molnár, D. (2013) · Journal of Obesity · doi:10.1155/2013/828463 · Cited by 4 · see citing works
Mecanismos de regulación del apetito y síndrome de Prader-Willi
Caixàs, A. (2006) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(06)71085-3 · Cited by 2 · see citing works
Síndrome de Prader-Willi: aspectos endocrino-metabólicos y de regulación del apetito
Caixàs, A., Giménez‐Palop, O., & de Endocrinología, S. (2009) · Cited by 1 · see citing works
Neurodevelopmental and Neuropsychological Aspects of Prader-Willi Syndrome
Whitman, B. Y., & Heithaus, J. L. (2022) · Springer eBooks · doi:10.1007/978-3-030-98171-6_8
Imran, J., Hasan, S., Sheuly, A., Rahman, S. I., Hossain, K. N., Rouf, R. S. B., Afsana, F., Pathan, M. F., & Amin, M. F. (2023) · Bangladesh Journal of Endocrinology and Metabolism · doi:10.4103/bjem.bjem_22_23
- Authors
- Fieldstone, A., Zipf, W. B., Sarter, M. F., & Berntson, G. G.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Zipf, William B.
- Venue
- Obesity Research
- Publisher
- Wiley
- Published
- 1998-01
- Volume
- 6
- Issue
- 1
- Pages
- 29-33
- ISSN
- 1071-7323 (ISSN-L)
- 1550-8528
- OpenAlex
- W2093016228
- Cited by
- 20
- References
- 26
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ohio State University
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- Prader-Willi syndrome, hyperphagia, dietary intake, chlordiazepoxide, benzodiazepine receptor agonists, obesity, appetite, drug metabolism
- MeSH terms
- Adolescent, Adult, Child, Chlordiazepoxide, Eating, Female, Humans, Male, Obesity, Prader-Willi Syndrome, GABA-A Receptor Agonists
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