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Gentamicin Pharmacokinetics in Term Neonates Receiving Extracorporeal Membrane Oxygenation
Open accessAbstract
Extracorporeal membrane oxygenation (ECMO) may affect the pharmacokinetics of certain drugs. The objectives of this study were to determine (1) the pharmacokinetics of gentamicin in neonates on ECMO and compare them to reported values for a similar patient population not on ECMO, (2) if the pharmacokinetics of gentamicin differ between venous‐venous and venous‐arterial bypass, and (3) if the pharmacokinetics of gentamicin are affected by oxygenator surface area (0.6 m 2 vs 0.8 m 2 oxygenators). The medical records of 29 term neonates who received gentamicin while on ECMO were reviewed. Data collected included gentamicin dosage, peak and trough serum concentrations determined at steady state, duration of treatment, time on ECMO, daily weights, and pertinent laboratory values. An initial dosage of gentamicin 2.5 mg/kg every 18 hours is suggested for term neonates on ECMO. Dosage adjustments should be based on gentamicin serum concentrations, and modifications may also be required after ECMO.
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“While few trials exist which help to guide drug dosing on ECLS, a trend has emerged demonstrating a larger volume of distribution and extended elimination time while on ECLS.[8–12]”
From Phenobarbital use in an infant requiring extracorporeal membrane life support (2013) · cites this paper as [11]
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Research works printed but not linked: 16
- Bartlett RH., 1984, Extracorporeal membrane oxygenation in neonates, Hosp Pract, 4, 139, 10.1080/21548331.1984.11702803 · DOI
- Extracorporeal Life Support Registry., 1991, Data on file
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- 10.1203/00006450-198605000-00001 · DOI
- 10.1016/S0272-6386(85)80099-8 · DOI
- 10.1159/000457685 · DOI
- Zenk KE, 1984, Effect of body weight on gentamicin pharmacokinetics in neonates, Clin Pharm, 3, 170
- 10.1016/S0022-3476(80)80506-3 · DOI
- McCraken G, 1970, Gentamicin in the neonatal period, Am J Dis Child, 120, 524
- 10.1016/S0022-3476(85)80691-0 · DOI
- 10.1128/AAC.33.6.817 · DOI · Paper page
- SwigartSA HoieEB WillettLD NelsonRMJr.Pharmacokinetics of gentamicin and vancomycin in infants undergoing ECMO. Presented at the 4th annual Children's Hospital National Medical Center ECMO symposium Snowmass Co. Feb 2126 1988.
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- Sell LL, 1987, Hypertension during extracorporeal membrane oxygenation: cause, effect, and management, Surgery, 102, 724
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Cited by
Buck, M. L. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342050-00001 · Cited by 179
Phenobarbital use in an infant requiring extracorporeal membrane life support
Tobias, J., Schloss, B., & Hayes, D. (2013) · Journal of Anaesthesiology Clinical Pharmacology · doi:10.4103/0970-9185.105811 · Cited by 4
“Deranged renal function seems to be a reasonable explanation as renal blood flow, glomerular filtration, and urine output are frequently decreased while on ECLS.”
BackgroundInfluential
Metadata
- Authors
- Bhatt‐Mehta, V., Johnson, C. E., & Schumacher, R. E.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Bhatt‐Mehta, Varsha
- ORCID
- Bhatt‐Mehta, Varsha
- Venue
- Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
- Publisher
- Wiley
- Published
- 1992-01-02
- Volume
- 12
- Issue
- 1
- Pages
- 28-32
- ISSN
- 0277-0008 (ISSN-L)
- 1875-9114
- OpenAlex
- W4387877187
- Cited by
- 70
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 8
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Mechanical Circulatory Support Devices
- Keywords
- gentamicin, pharmacokinetics, extracorporeal membrane oxygenation, term infants, aminoglycoside dosing, serum drug concentration, neonatal pharmacotherapy
- MeSH terms
- Bacterial Infections, Gentamicins, Half-Life, Hernia, Diaphragmatic, Humans, Infant, Newborn, Meconium Aspiration Syndrome, Metabolic Clearance Rate, Oxygenators, Membrane, Pneumonia, Respiratory Distress Syndrome, Newborn, Retrospective Studies, Extracorporeal Membrane Oxygenation
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- CoChat. (2026). Citation check: Gentamicin Pharmacokinetics in Term Neonates Receiving Extracorporeal Membrane Oxygenation. https://app.cochat.ai/papers/10.1002/j.1875-9114.1992.tb02667.x
- The paper
- Bhatt‐Mehta, V., Johnson, C. E., & Schumacher, R. E. (1992). Gentamicin Pharmacokinetics in Term Neonates Receiving Extracorporeal Membrane Oxygenation. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. https://doi.org/10.1002/j.1875-9114.1992.tb02667.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
