The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormone-binding globulin bound testosterone in healthy young and elderly men
Open accessAbstract
The circadian pattern in levels of serum total testosterone (T) in men becomes blunted with normal aging. However, because T not bound to sex hormone‐binding globulin (non‐SHBG‐T) is felt to be a better representative of biologically available T than is total T, the possibility of a 24‐h variation in non‐SHBG‐T in young men and the possibility that aging is associated with a blunting of that rhythm were investigated. Hourly blood samples were drawn on 10 normal young men (mean age 27.3 years) and 10 normal elderly men (mean age 70.7 years) over a 24‐h period and the serum was assayed for total T, sex hormone‐binding globulin (SHBG), and total protein; non‐SHBG‐T was calculated. SHBG was determined by radioimmunoassay as well as by a steroid‐binding assay. Young men had a significantly higher (p < 0.05) mean 24‐h level of non‐SHBG‐T (1.91 ± 0.62 nm/l) than did the elderly men (0.86 ± 0.01 nM/l). Also, each young man showed a significant circadian rhythm in non‐SHBG‐T, with a group mean daily variation of 1.42 ± 0.38 nM/l. In contrast, only 60% of the elderly men demonstrated a significant circadian rhythm in non‐SHBG‐T, and the group mean rhythm was blunted (maximum excursion 0.38 ± 0.07 nM/l) compared with that of the young men. SHBG and total protein levels demonstrated similar 24‐h variations in the two age groups. It was concluded that non‐SHBG‐T serum levels, similar to serum total T levels, demonstrate a circadian pattern in young men and this circadian rhythmicity becomes blunted with normal aging.
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“A meta-analysis of studies reviewing the effect of weight loss on T demonstrated mean T increases of 83 ng/dl (diet alone [2.9 nmol/L]) and 252 ng/dl (bariatric surgery [8.7 nmol/L]), with greater improvements in bariatric surgery attributed to the more extensive weight loss achieved.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [71]
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“A 4–5 point increase in BMI is roughly equivalent to a 10-year decline in T, while weight loss directly correlates with increasing T.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [71]
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Cites
Methods for cosinor-rhythmometry.
Nelson, W. E., Tong, Y. L., Lee, J. K., & Franz Halberg, A. (1979) · PubMed · Cited by 1,701
Loss of Circadian Rhythmicity in Blood Testosterone Levels with Aging in Normal Men*
Bremner, W. J., Vitiello, M. V., & Prinz, P. N. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-6-1278 · Cited by 785
Self-citationMoore, R. Y. (1983) · PubMed · Cited by 687
Frontiers in neuroendocrinology
Fink, G. R. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90148-9 · Cited by 345
Tenover, J. L., Matsumoto, A. M., Plymate, S. R., & Bremner, W. J. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-6-1118 · Cited by 256
Self-citationDecreased Bioavailable Testosterone in Aging Normal and Impotent Men*
Nankin, H. R., & CALKINS, J. H. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-6-1418 · Cited by 236
Corticotropin-Releasing Hormone Inhibits Gonadotropin Secretion in the Ovariectomized Rhesus Monkey*
Olster, D. H., & Ferin, M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-2-262 · Cited by 188
Tenover, J. L., Matsumoto, A. M., Clifton, D. K., & Bremner, W. J. (1988) · Journal of Gerontology · doi:10.1093/geronj/43.6.m163 · Cited by 185
Self-citationObesity and Its Role in Poly cystic Ovary Syndrome*
Plymate, S. R., Fariss, B. L., BASSETT, M. L., & Matej, L. A. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-52-6-1246 · Cited by 109
Self-citationMontanini, V., Simoni, M., Chiossi, G., Baraghini, G. F., Velardo, A., Baraldi, E., & Manama, P. (1988) · Hormone Research · doi:10.1159/000180956 · Cited by 100
Research works printed but not linked: 2
- Kaiser FE, 1988, Impotence and aging: Alterations in hormonal secretory patterns with age, Clin Res (Abst), 36, 96A
- Nelson W., 1979, Methods for cosinorrhythmometry, Chronobiologia, 6, 305
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An, G. J. (2017) · Journal of Korean Biological Nursing Science · doi:10.7586/jkbns.2020.22.2.71 · Cited by 1
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Morgentaler, A. (2004) · Current Sexual Health Reports · doi:10.1007/s11930-004-0008-1 · Cited by 1
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Morales, Á. (2003) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.4.6.911 · Cited by 1
Cunningham, G. R., & Hirshkowitz, M. (1997) · Springer eBooks · doi:10.1007/978-1-4612-1848-7_24 · Cited by 1
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Sistema psiconeuroendocrino y envejecimiento
Alvarez, X. A., Franco, A., & Cacabelos, R. (1990) · Digitum: Institutional Repository of the University of Murcia (University of Murcia)
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Kish, K. (2014) · Brock University Digital Repository (Brock University)
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Smolensky, M. H., Hermida, R. C., Sackett-Lundeen, L. L., Hermida‐Ayala, R. G., & Geng, Y. (2022) · Comprehensive physiology · doi:10.1002/cphy.c220014
Chu, L. W., Meyer, T. E., Li, Q., Menashe, I., Yu, K. F., Rosenberg, P. S., Huang, W., Quraishi, S. M., Kaaks, R., Weiss, J. M., et al. (2023) · doi:10.1158/1055-9965.c.6515004
Lin, D. W., FitzGerald, L. M., Fu, R., Kwon, E. M., Zheng, S. L., Kolb, S., Wiklund, F. E., Stattin, P. E., Isaacs, W. B., Xu, J., et al. (2023) · doi:10.1158/1055-9965.c.6515007
Chu, L. W., Meyer, T. E., Li, Q., Menashe, I., Yu, K. F., Rosenberg, P. S., Huang, W., Quraishi, S. M., Kaaks, R., Weiss, J. M., et al. (2023) · doi:10.1158/1055-9965.c.6515004.v1
Lin, D. W., FitzGerald, L. M., Fu, R., Kwon, E. M., Zheng, S. L., Kolb, S., Wiklund, F. E., Stattin, P. E., Isaacs, W. B., Xu, J., et al. (2023) · doi:10.1158/1055-9965.c.6515007.v1
Smolensky, M. H., Hermida, R. C., Sackett-Lundeen, L. L., Hermida‐Ayala, R. G., & Geng, Y. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00245.x
Chiang, I., & Hsu, G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21477-6.00464-8
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Nelson, J. F. (1994) · Comprehensive physiology · doi:10.1002/j.2040-4603.1994.tb01687.x
Problème: vieillissement masculin
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Stolk, T. H. R., van Mello, N. M., Hannema, S. E., Boogers, L. S., Meißner, A., de Melker, A. A., van der Voorn, J. P., Huirne, J. A. F., & van den Boogaard, E. (2026) · International Journal of Transgender Health · doi:10.1080/26895269.2026.2653093
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Kevorkian, R. T., & Morley, J. E. (2003) · Springer eBooks · doi:10.1007/978-94-017-0673-5_13
Metadata
- Authors
- PLYMATE, S. R., TENOVER, J. S., & BREMNER, W. J.
- Affiliations
- Madigan Army Medical Center (US)
- University of Washington (US)
- Corresponding author
- PLYMATE, STEPHEN R.
- Venue
- Journal of Andrology
- Publisher
- Wiley
- Published
- 1989-09-10
- Volume
- 10
- Issue
- 5
- Pages
- 366-371
- ISSN
- 0196-3635 (ISSN-L)
- 1939-4640
- OpenAlex
- W1889567471
- Semantic Scholar
- a0c6ba380ca4bed7281807f37cac956faa1f58b6
- Cited by
- 239
- References
- 19
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 5 · 2020: 8 · 2019: 9 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 10 · 2014: 12 · 2013: 13 · 2012: 5
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Andrology (publishedVersion)
- PubMed (publishedVersion)
- ResearchWorks at the University of Washington (University of Washington) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- circadian rhythm, testosterone, sex hormone-binding globulin, free testosterone, aging, older men, young men, diurnal variation, total protein
- MeSH terms
- Adult, Aged, Aging, Blood Proteins, Circadian Rhythm, Humans, Male, Sex Hormone-Binding Globulin, Testosterone
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