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Normal and Abnormal Development of the Male Urogenital Tract: Role of Androgens, Mesenchymal‐Epithelial Interactions, and Growth Factors
Open accessAbstract
ABSTRACT: Androgen‐dependent male urogenital development occurs via mesenchymal‐epithelial interactions in which mesenchyme induces epithelial morphogenesis, regulates epithelial proliferation, and evokes expression of tissue‐specific secretory proteins. Mesenchymal‐epithelial interactions continue to be important into adulthood. For example, mesenchyme of the urogenital sinus (UGM) and seminal vesicle (SVM) induce dramatic morphologic and functional changes in various adult epithelia. Since adult epithelial cells are unquestionably responsive to mesenchymes that can elicit expression of alternative morphologic and functional phenotypes, established carcinomas might also be influenced by their connective tissue environment. In this regard, Dunning prostatic tumor has been induced by UGM or SVM to differentiate into tall columnar secretory epithelial cells. This change in cytodifferentiation is associated with a reduction in growth rate and loss of tumorigenesis. The role of soluble growth factors in the mechanism of mesenchymal‐epithelial interactions is discussed.
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Cited by
Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium
Olumi, A., Grossfeld, G., Hayward, S., Carroll, P., Cunha, G., Hein, P., & Tlsty, T. (2000) · Breast Cancer Research · doi:10.1186/bcr138 · Cited by 1,463
Self-citationvan Genderen, C., Okamura, R. M., Fariñas, I., Quo, R. G., Parslow, T. G., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 965
Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium
Cooke, P. S., Buchanan, D. L., Young, P., Setiawan, T., Brody, J., Korach, K. S., Taylor, J., Lubahn, D. B., & Cunha, G. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6535 · Cited by 554
Self-citationYan, G., Fukabori, Y., McBride, G., Nikolaropolous, S., & McKeehan, W. L. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4513 · Cited by 403
Hayward, S. W., Dahiya, R., Cunha, G. R., Bartek, J., Deshpande, N., & Narayan, P. (1995) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02631333 · Cited by 340
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Metadata
- Authors
- CUNHA, G. R., ALARID, E. T., TURNER, T., DONJACOUR, A. A., BOUTIN, E. L., & FOSTER, B. A.
- Venue
- Journal of Andrology
- Publisher
- Wiley
- Published
- 1992-11-12
- Volume
- 13
- Issue
- 6
- Pages
- 465-475
- ISSN
- 0196-3635 (ISSN-L)
- 1939-4640
- OpenAlex
- W4387113319
- Cited by
- 219
- References
- 0
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Normal and Abnormal Development of the Male Urogenital Tract: Role of Androgens, Mesenchymal‐Epithelial Interactions, and Growth Factors. https://app.cochat.ai/papers/10.1002/j.1939-4640.1992.tb00338.x
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- CUNHA, G. R., ALARID, E. T., TURNER, T., DONJACOUR, A. A., BOUTIN, E. L., & FOSTER, B. A. (1992). Normal and Abnormal Development of the Male Urogenital Tract: Role of Androgens, Mesenchymal‐Epithelial Interactions, and Growth Factors. Journal of Andrology. https://doi.org/10.1002/j.1939-4640.1992.tb00338.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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