The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.
Open accessAbstract
Stroma and the heparin-binding fibroblast growth factor (FGF) family influence normal epithelial cell growth and differentiation in embryonic and adult tissues. The role of stromal cells and the expression of isoforms of the FGF ligand and receptor family were examined during malignant progression of epithelial cells from a differentiated, slowly growing, nonmalignant model rat prostate tumor. In syngeneic hosts, a mixture of stromal and epithelial cells resulted in nonmalignant tumors which were differentiated and slowly growing. In the absence of the stromal cells, epithelial cells progressed to malignant tumors which were independent of the stroma and undifferentiated. The independence of the malignant epithelial cells from stromal cells was accompanied by a switch from exclusive expression of exon IIIb to exclusive expression of exon IIIc in the FGF receptor 2 (FGF-R2) gene. The FGF-R2(IIIb) isoform displays high affinity for stromal cell-derived FGF-7, whereas the FGF-R2(IIIc) isoform does not recognize FGF-7 but has high affinity for the FGF-2 member of the FGF ligand family. The switch from expression of exclusively exon IIIb to exclusively exon IIIc in the resident FGF-R2 gene was followed by activation of the FGF-2 ligand gene, the normally stromal cell FGF-R1 gene, and embryonic FGF-3 and FGF-5 ligand genes in malignant epithelial cells. Multiple autocrine and potentially intracrine ligand-receptor loops resulting from these alterations within the FGF-FGF-R family may underlie the autonomy of malignant tumor cells.
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Fibroblast growth factor signalling: from development to cancer
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Receptor Specificity of the Fibroblast Growth Factor Family
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Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium
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Receptor Specificity of the Fibroblast Growth Factor Family
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Metadata
- Authors
- Yan, G., Fukabori, Y., McBride, G., Nikolaropolous, S., & McKeehan, W. L.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1993-08
- Volume
- 13
- Issue
- 8
- Pages
- 4513-4522
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1930373062
- Cited by
- 403
- References
- 41
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Yan, G., Fukabori, Y., McBride, G., Nikolaropolous, S., & McKeehan, W. L. (1993). Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.13.8.4513
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