The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Novel current‐conducting composite substrates for exposing osteoblasts to alternating current stimulation
Abstract
The present study demonstrates that novel nanocomposites consisting of blends of polylactic acid and carbon nanotubes effectively can be used to expose cells to electrical stimulation. When osteoblasts cultured on the surfaces of these nanocomposites were exposed to electric stimulation (10 μA at 10 Hz) for 6 h/day for various periods of time, there was a 46% increase in cell proliferation after 2 days, a 307% increase in the concentration of extracellular calcium after 21 consecutive days, and upregulation of mRNA expression for collagen type‐I after both 1 and 21 consecutive days. These results provide evidence that electrical stimulation delivered through novel, current‐conducting polymer/nanophase composites promotes osteoblast functions that are responsible for the chemical composition of the organic and inorganic phases of bone. Furthermore, this evidence elucidates aspects of the cellular/molecular‐level mechanisms involved in new bone formation under electrical stimulation. © 2001 Wiley Periodicals, Inc. J Biomed Mater Res 59: 499–506, 2002
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Yasuda, H., Shima, N., Nakagawa, N., Mochizuki, S.-I., Yano, K., Fujise, N., Sato, Y., Goto, M., Yamaguchi, K., Kuriyama, M., et al. (1998) · Endocrinology · doi:10.1210/endo.139.3.5837 · Cited by 1,201
Cited by
The biocompatibility of carbon nanotubes
Smart, S. K., Cassady, A. I., Lu, G. Q., & Martin, D. J. (2006) · Carbon · doi:10.1016/j.carbon.2005.10.011 · Cited by 1,011
Bacakova, L., Filova, E., Parizek, M., Ruml, T., & Svorcik, V. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.06.004 · Cited by 1,000
Ghasemi-Mobarakeh, L., Prabhakaran, M. P., Morshed, M., Nasr-Esfahani, M. H., Baharvand, H., Kiani, S., Al-Deyab, S. S., & Ramakrishna, S. (2011) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.383 · Cited by 698
Correa-Duarte, M. A., Wagner, N., Rojas-Chapana, J., Morsczeck, C., Thie, M., & Giersig, M. (2004) · Nano Letters · doi:10.1021/nl048574f · Cited by 481
Osteoblast function on electrically conductive electrospun PLA/MWCNTs nanofibers
Shao, S., Zhou, S., Li, L., Li, J., Luo, C., Wang, J., Li, X., & Weng, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.051 · Cited by 320
Metadata
- Authors
- Supronowicz, P. R., Ajayan, P. M., Ullmann, K. R., Arulanandam, B. P., Metzger, D. W., & Bizios, R.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 2001-12-06
- Volume
- 59
- Issue
- 3
- Pages
- 499-506
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W2052974206
- Cited by
- 366
- References
- 1
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Supronowicz, P. R., Ajayan, P. M., Ullmann, K. R., Arulanandam, B. P., Metzger, D. W., & Bizios, R. (2002). Novel current‐conducting composite substrates for exposing osteoblasts to alternating current stimulation. Journal of Biomedical Materials Research. https://doi.org/10.1002/jbm.10015
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