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Biodegradable poly(lactic acid) polymers
Abstract
The synthesis of poly(lactic acids) from the cyclic lactides and properties of the polymers prepared have been described. Degradation rates in vitro under homogeous and heterogeneous conditions have been measured. The kinetics of deesterification under homogeneous conditions is second order and an activation energy of 11 Kcal/mol has been calculated. This is comparable to the value found for the hydrolysis of alkyl acetates. A biological in vitro method for determining the degradation of poly(lactic acids) has been described. The method indicates, in accordance with expectations, that poly(dl‐lactic acid) degrades at a faster rate than L(+) lactic acid. Initial results of medical evaluation of the polymers in suture, rod, and film form are presented.
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Cited by
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The return of a forgotten polymer—Polycaprolactone in the 21st century
Woodruff, M. A., & Hutmacher, D. W. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.04.002 · Cited by 4,033
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070
Biomaterial developments for bone tissue engineering
Burg, K. J. L., Porter, S., & Kellam, J. F. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00102-2 · Cited by 1,643
Navarro, M., Michiardi, A., Castaño, O., & Planell, J. A. (2008) · Journal of The Royal Society Interface · doi:10.1098/rsif.2008.0151 · Cited by 1,513
Metadata
- Authors
- Kulkarni, R. K., Moore, E. G., Hegyeli, A. F., & Leonard, F.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1971-05
- Volume
- 5
- Issue
- 3
- Pages
- 169-181
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W1963908464
- Cited by
- 799
- References
- 0
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Biodegradable poly(lactic acid) polymers. https://app.cochat.ai/papers/10.1002/jbm.820050305
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- Kulkarni, R. K., Moore, E. G., Hegyeli, A. F., & Leonard, F. (1971). Biodegradable poly(lactic acid) polymers. Journal of Biomedical Materials Research. https://doi.org/10.1002/jbm.820050305
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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