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Direct chemical bond of bioactive glass‐ceramic materials to bone and muscle
Abstract
The objective of this research is to achieve direct chemical bonding of structurally strong implant materials with hard and soft tissues. This objective has been achieved through the development of a series of surface‐active bioglasses and bioglass‐ceramics. A controlled release of Ca, P, and Na ions from the surface of the materials produces an alkaline pH and nutrient constituents at a time when the body can incorporate the ions into newly formed tissues. Optical and electron microscopy of in‐vivo implants in rat femurs and muscles show the development of stable chemically bonded physiological interfaces after 6 weeks. Microstructure and crystallinity of the materials do not influence the bonding achieved. Mechanical measurements of the bond strength in bone show that the bone fractures before the interface does. In‐vitro studies of protein epitaxy, hydroxyapatite crystallization, and solubility kinetics correlate with the proposed interfacial bonding theory.
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Citations
Cited by
Polymeric materials for bone and cartilage repair
Puppi, D., Chiellini, F., Piras, A. M., & Chiellini, E. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.01.006 · Cited by 913
Bioceramics: Past, present and for the future
Best, S. M., Porter, A. E., Thian, E. S., & Huang, J. (2008) · Journal of the European Ceramic Society · doi:10.1016/j.jeurceramsoc.2007.12.001 · Cited by 851
Bioactive Glasses: Frontiers and Challenges
Hench, L. L., & Jones, J. R. (2015) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2015.00194 · Cited by 406
Self-citationFernandes, H. R., Gaddam, A., Rebelo, A., Brazete, D., Stan, G. E., & Ferreira, J. M. F. (2018) · Materials · doi:10.3390/ma11122530 · Cited by 397
Hing, K. A., Revell, P. A., Smith, N., & Buckland, T. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.05.039 · Cited by 375
Metadata
- Authors
- Hench, L. L., & Paschall, H. A.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1973-05
- Volume
- 7
- Issue
- 3
- Pages
- 25-42
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W1997491556
- Cited by
- 942
- References
- 0
- FWCI
- 11.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hench, L. L., & Paschall, H. A. (1973). Direct chemical bond of bioactive glass‐ceramic materials to bone and muscle. Journal of Biomedical Materials Research. https://doi.org/10.1002/jbm.820070304
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
