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Cited by 397Bone Tissue Engineering MaterialsGlass properties and applicationsbiodegradable polymer synthesis and properties

Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

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Fernandes, Hugo R., Gaddam, Anuraag, Rebelo, Avito, Brazete, Daniela, Stan, George E., Ferreira, José M. F.·2018·Materials
DOI 10.3390/ma11122530PMC PMC6316906
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Abstract

The discovery of bioactive glasses (BGs) in the late 1960s by Larry Hench et al. was driven by the need for implant materials with an ability to bond to living tissues, which were intended to replace inert metal and plastic implants that were not well tolerated by the body. Among a number of tested compositions, the one that later became designated by the well-known trademark of 45S5 Bioglass® excelled in its ability to bond to bone and soft tissues. Bonding to living tissues was mediated through the formation of an interfacial bone-like hydroxyapatite layer when the bioglass was put in contact with biological fluids in vivo. This feature represented a remarkable milestone, and has inspired many other investigations aiming at further exploring the in vitro and in vivo performances of this and other related BG compositions. This paradigmatic example of a target-oriented research is certainly one of the most valuable contributions that one can learn from Larry Hench. Such a goal-oriented approach needs to be continuously stimulated, aiming at finding out better performing materials to overcome the limitations of the existing ones, including the 45S5 Bioglass®. Its well-known that its main limitations include: (i) the high pH environment that is created by its high sodium content could turn it cytotoxic; (ii) and the poor sintering ability makes the fabrication of porous three-dimensional (3D) scaffolds difficult. All of these relevant features strongly depend on a number of interrelated factors that need to be well compromised. The selected chemical composition strongly determines the glass structure, the biocompatibility, the degradation rate, and the ease of processing (scaffolds fabrication and sintering). This manuscript presents a first general appraisal of the scientific output in the interrelated areas of bioactive glasses and glass-ceramics, scaffolds, implant coatings, and tissue engineering. Then, it gives an overview of the critical issues that need to be considered when developing bioactive glasses for healthcare applications. The aim is to provide knowledge-based tools towards guiding young researchers in the design of new bioactive glass compositions, taking into account the desired functional properties.

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References 340 · Cited by 397

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Authors
Fernandes, H. R., Gaddam, A., Rebelo, A., Brazete, D., Stan, G. E., & Ferreira, J. M. F.
Affiliations
  • University of Aveiro (PT)
  • National Institute of Materials Physics (RO)
Corresponding author
Ferreira, José M. F.
ORCID
Venue
Materials
Publisher
MDPI AG
Published
2018-12-12
Volume
11
Issue
12
Pages
2530
ISSN
1996-1944 (ISSN-L)
DOI
10.3390/ma11122530
PMC
PMC6316906
OpenAlex
W2905447985
Cited by
397
References
340
Citations by year
2026: 54 · 2025: 72 · 2024: 63 · 2023: 58 · 2022: 52 · 2021: 36 · 2020: 43 · 2019: 19
FWCI
2.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Materials (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Ciência e a Tecnologia (FCT), Portugal (SFRH/BPD/110883/2015)
  • Fundação para a Ciência e a Tecnologia (FCT), Portugal (SFRH/BPD/110883/2015)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Ceramics and Composites › Glass properties and applications
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords
bioactive glass, glass-ceramics, bone regeneration, tissue engineering, 45S5 bioactive glass, hydroxyapatite formation, biocompatibility, degradation rate, sintering, porous scaffolds, implant coatings, implant materials

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