The DOI matches its Crossref record; 20 of the 22 references it cites were found in a registry or an index.
Design of an artificial skin. Part III. Control of pore structure
Abstract
Several methods are compared for preparing collagen‐glycosaminoglycan (GAG) membranes of high or low porosity. Collagen‐GAG membranes have been used to cover satisfactorily large experimental full‐thickness skin wounds in guinea pigs over the past few years. Methods studies as means for controlling pore size are confined to purely physical processes which do not require use of additives or chemical reagents to form the porous membrane. We find that membranes, initially swollen in distilled water or saline, shrink linearly to no less than 94% of original dimension after freeze drying; to 75% after critical point drying (from CO 2, following water‐ethanol exchange); and to 41% of original dimension following air drying from the swollen state. Scanning electron microscopic study of the pore structure resulting from each drying procedure confirms our major conclusion: A carefully designed freeze drying process, two variants of which are described in detail, yields membranes with the highest mean pore size, as measured by quantitative stereological procedures. Critical point drying gave significantly more shrinkage and a lower mean pore size than either one of the two freeze drying procedures used.
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“Pore size has always been a crucial property of tissue engineering scaffolds and a key determinant of a scaffold’s success through their influence on cell infiltration, nutrient/oxygen exchange, and angiogenesis [41, 42].”
From Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds (2013) · cites this paper as [42]
Citations
Cites
Encyclopedia of polymer science and technology
(2003) · Choice Reviews Online · doi:10.5860/choice.41-0674 · Cited by 5,100
Richards, O. W., de Hoff, R. T., & Rhines, F. N. (1969) · Transactions of the American Microscopical Society · doi:10.2307/3224516 · Cited by 1,279
Design of an artificial skin. I. Basic design principles
Yannas, I. V., & Burke, J. F. (1980) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820140108 · Cited by 1,045
Self-citationDesign of an artificial skin. I. Basic design principles
Yannas, I. V., & Burke, J. F. (1980) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820140314 · Cited by 889
Self-citationDesign of an artificial skin. II. Control of chemical composition
Yannas, I. V., Burke, J. F., Gordon, P. L., Huang, C., & Rubenstein, R. H. (1980) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820140203 · Cited by 590
Self-citationPreparation of animal tissues for surface‐scanning electron microscopy
BOYDE, A., & Wood, C. (1969) · Journal of Microscopy · doi:10.1111/j.1365-2818.1969.tb00709.x · Cited by 359
Stenzel, K. H., Miyata, T., & Rubin, A. L. (1974) · Annual Review of Biophysics and Bioengineering · doi:10.1146/annurev.bb.03.060174.001311 · Cited by 339
Medical and Surgical Applications of Collagen
Chvapil, M. S., Kronenthal, R. L., & Winkle, W. V. (1973) · International review of connective tissue research · doi:10.1016/b978-0-12-363706-2.50007-6 · Cited by 264
Correlation of in vivo collagen degradation rate with in vitro measurements
Yannas, I. V., Burke, J. F., Huang, C., & Gordon, P. L. (1975) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820090608 · Cited by 82
Self-citationSome chemical and biological characteristics of a new collagen–polymer compound material
Chvapil, M. S., Holusa, R., Kliment, K., & Štoll, M. (1969) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820030211 · Cited by 75
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2 of the 22 references couldn’t be matched to a known paper.
Research works printed but not linked: 10
- Yannas I. V., 1979, Progress in Design of an Artificial Skin, Fed. Proc., 38, 988
- I. V.Yannas J. F.Burke C.Huang andP. L.Gordon Control of Biodegradability Rate in Design of Collagen Skin Substitutes in Transactions of the 3rd Annual Meeting Society for Biomaterials and the 9th Annual International Biomaterials Symposium Vol.1 New Orleans LA 15–19 April1977 P.114;
- Yannas I. V., 1975, Suppression of in Vivo degradability and of Immunogenicity of Collagen by Reaction with Glycosaminoglycans, Am. Chem. Soc. Polym. Preprints, 16, 209
- I. V.Yannas “Characterization Techniques for the Molecular Design of Polymeric Implants ” Biomedical Materials Res. Conference Brighton UT 9–10 November 1972.
- A.Boyde “Biological Specimen Preparation for the Scanning Electron Microscope ” in Proceedings of the Fifth Electron Microscopy Symposium Scanning Electron Microscopy Part II 258–264(1972).
- Parham R. A., 1975, Critical‐point Drying for Fiber Microscopy, Tappi, 58, 138
- Cohen A. L., 1968, A Rapid Critical Point Method of using Fluorocarbons (Freons) as Intermediate and Transitional Fluids, J. Microsc. (Paris), 17, 331
- Cohen A. L., 1974, Principles and Techniques of Scanning Electron Microscopy, 44
- Kormendy A. C., 1975, Principles and Techniques of Scanning Electron Microscopy, 82
- H. F.Fischmeister “Determination of Pore Structure by Stereological Measurements ”Proceedings International Symposium RILEM/IUPAC Prague 18–21September1973 Final report Part II pp.C439–C476.
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O'Brien, F. J. (2011) · Materials Today · doi:10.1016/s1369-7021(11)70058-x · Cited by 3,437
Biomaterials based on chitin and chitosan in wound dressing applications
Jayakumar, R., Prabaharan, M., Kumar, P. T. S., Nair, S. V., & Tamura, H. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.01.005 · Cited by 1,927
Hierarchically porous materials: synthesis strategies and structure design
Yang, X., Chen, L., Li, Y., Rooke, J. C., Sánchez, C., & Su, B. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00829a · Cited by 1,461
Sachlos, E., & Czernuszka, J. T. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a03 · Cited by 1,305
Burke, J. F., Yannas, I. V., Quinby, W. C., Bondoc, C. C., & JUNG, W. K. (1981) · Annals of Surgery · doi:10.1097/00000658-198110000-00005 · Cited by 1,248
Self-citation
Metadata
- Authors
- Dagalakis, N., Flink, J., Stasikelis, P., Burke, J. F., & Yannas, I. V.
- Affiliations
- Harvard University (US)
- University of Copenhagen (DK)
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1980-07
- Volume
- 14
- Issue
- 4
- Pages
- 511-528
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W2014185746
- Cited by
- 358
- References
- 22
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 3 · 2020: 18 · 2019: 15 · 2018: 12 · 2017: 10 · 2016: 12 · 2015: 9 · 2014: 14 · 2013: 11 · 2012: 3
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Keywords
- artificial skin, pore size control, membrane porosity, freeze-drying, critical point drying, membrane shrinkage, full-thickness skin wounds, wound coverage, stereology
- MeSH terms
- Ethanol, Animals, Artificial Organs, Cattle, Chemistry, Physical, Collagen, Desiccation, Freeze Drying, Glycosaminoglycans, Membranes, Artificial, Microscopy, Microscopy, Electron, Scanning, Prosthesis Design, Skin, Surface Properties, Water, Chemical Phenomena
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