Cited by 3,437Bone Tissue Engineering MaterialsTissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical Applications

Biomaterials & scaffolds for tissue engineering

Open access
O'Brien, Fergal J.·2011·Materials Today

Abstract

Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease or trauma. The developing field of tissue engineering (TE) aims to regenerate damaged tissues by combining cells from the body with highly porous scaffold biomaterials, which act as templates for tissue regeneration, to guide the growth of new tissue. This article describes the functional requirements, and types, of materials used in developing state of the art of scaffolds for tissue engineering applications. Furthermore, it describes the challenges and where future research and direction is required in this rapidly advancing field.

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Crossref · 10.1016/s1369-7021(11)70058-x

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  • Polymer micelles can physically encapsulate hydrophobic drugs in their hydrophobic core effectively, resulting in advantages including elimination of drug side effects, increased water solubility, control of drug release rate, and protection of drug molecules from degradation by specific media.

    “Polymer micelles can simply physically encapsulate (solubilize) hydrophobic drugs in their hydrophobic core effectively, resulting in the following advantages: (i) elimination of drug side effects; (ii) Increase the water solubility of hydrophobic and insoluble drugs; (iii) Control of drug release rate; (iv) Protect drug molecules from degradation by specific media (pH, temperature).”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [36]

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Research works printed but not linked: 4

  1. Brown, B.N., et al. Biomaterials (2009) 30 (8), 1482.
  2. Lyons, F., et al., Biomaterials (2010) 31(35), 9232.
  3. Partap, S. et al., Scaffolds & Surfaces. In: Basic Engineering for Medics and Biologists, An ESEM Primer on Engineering for Medicine, Lee, T.C. and Niederer, P. (Eds.) IOS Press, Nieuwe Hemweg, (2010) 152, 187.
  4. Smith, I.O. et al., Wiley Interdiscip Rev Nanomed Nanobiotechnol (2009) 1, 226.

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Authors
O'Brien, F. J.
Venue
Materials Today
Publisher
Elsevier BV
Published
2011-03
Volume
14
Issue
3
Pages
88-95
ISSN
1369-7021 (ISSN-L)
OpenAlex
W2101601223
Cited by
3,437
References
84
Citations by year
2026: 189 · 2025: 231 · 2024: 231 · 2023: 299 · 2022: 308 · 2021: 414 · 2020: 446 · 2019: 422 · 2018: 313 · 2017: 268 · 2016: 145 · 2015: 83 · 2014: 45 · 2013: 20 · 2012: 17
FWCI
16.83
Type
journal article
Language
en
Open access
Locations
Materials Today (publishedVersion, cc-by-nc-nd)
Funders
  • Royal College of Surgeons in Ireland
  • Enterprise Ireland
  • Science Foundation Ireland
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords
tissue engineering, scaffolds, biomaterials, tissue regeneration, porous media, tissue repair

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