Biomaterials & scaffolds for tissue engineering
Open accessAbstract
Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease or trauma. The developing field of tissue engineering (TE) aims to regenerate damaged tissues by combining cells from the body with highly porous scaffold biomaterials, which act as templates for tissue regeneration, to guide the growth of new tissue. This article describes the functional requirements, and types, of materials used in developing state of the art of scaffolds for tissue engineering applications. Furthermore, it describes the challenges and where future research and direction is required in this rapidly advancing field.
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Polymer micelles can physically encapsulate hydrophobic drugs in their hydrophobic core effectively, resulting in advantages including elimination of drug side effects, increased water solubility, control of drug release rate, and protection of drug molecules from degradation by specific media.
“Polymer micelles can simply physically encapsulate (solubilize) hydrophobic drugs in their hydrophobic core effectively, resulting in the following advantages: (i) elimination of drug side effects; (ii) Increase the water solubility of hydrophobic and insoluble drugs; (iii) Control of drug release rate; (iv) Protect drug molecules from degradation by specific media (pH, temperature).”
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<i>In vitro</i> functional models for human liver diseases and drug screening: beyond animal testing
Paradiso, A., Volpi, M., Rinoldi, C., Celikkin, N., Contessi Negrini, N., Bilgen, M., Dallera, G., Pierini, F., Costantini, M., Święszkowski, W., et al. (2023) · Biomaterials Science · doi:10.1039/d1bm01872h · Cited by 40 · see citing works
Wu, W., Zhou, Z., Sun, G., Liu, Y., Zhang, A., & Chen, X. (2021) · Materials Science and Engineering: C · doi:10.1016/j.msec.2021.111919 · Cited by 33 · see citing works
Goulian, A. J., Goldstein, B., & Saad, M. A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14062061 · Cited by 25 · see citing works
“2 of 23 Biomimetic materials, including engineered scaffolds and autologous protein solutions, represent an emerging class of regenerative therapies aimed at mimicking natural tissue environments to facilitate healing and integration [28,29].”
Applications of cellulose nanofibrils in drug delivery
Gopi, S., Balakrishnan, P., Geethamma, V. G., Pius, A., & Thomas, S. (2018) · Applications of Nanocomposite Materials in Drug Delivery · doi:10.1016/b978-0-12-813741-3.00004-2 · Cited by 13 · see citing works
Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account?
Galvan, A., Pellicciari, C., & Calderan, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021165 · Cited by 11 · see citing works
Matching together living cells and prototissues: will there Be chemistry?
Valente, S., Galanti, A., Maghin, E., Najdi, N., Piccoli, M., & Gobbo, P. (2024) · ChemBioChem · doi:10.1002/cbic.202400378 · Cited by 10 · see citing works
- Authors
- O'Brien, F. J.
- Venue
- Materials Today
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 14
- Issue
- 3
- Pages
- 88-95
- ISSN
- 1369-7021 (ISSN-L)
- OpenAlex
- W2101601223
- Cited by
- 3,437
- References
- 84
- Citations by year
- 2026: 189 · 2025: 231 · 2024: 231 · 2023: 299 · 2022: 308 · 2021: 414 · 2020: 446 · 2019: 422 · 2018: 313 · 2017: 268 · 2016: 145 · 2015: 83 · 2014: 45 · 2013: 20 · 2012: 17
- FWCI
- 16.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Materials Today (publishedVersion, cc-by-nc-nd)
- Funders
- Royal College of Surgeons in Ireland
- Enterprise Ireland
- Science Foundation Ireland
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- tissue engineering, scaffolds, biomaterials, tissue regeneration, porous media, tissue repair
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