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Cited by 259

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Protein adsorption to polymer particles: Role of surface properties

Absolom, D. R., Zingg, W., Neumann, A. W.·1987·Journal of Biomedical Materials Research

Abstract

Adsorption isotherms of four plasma proteins (fibrinogen, IgG, human serum albumin, and bovine serum albumin) using four different types of small particles as substrates (siliconized glass, Teflon, polyvinylchloride, and Nylon‐6, 6) are reported. The suspending liquid medium was phosphate‐buffered saline, with a surface tension higher than that of any of the proteins. In keeping with the thermodynamic expectations for these systems, protein adsorption decreases for all solids in sequence from fibrinogen (the most hydrophobic) to IgG, human serum albumin, and bovine serum albumin (the most hydrophilic). Furthermore, the extent of protein adsorption also decreases from the low surface tension (hydrophobic) to the higher surface tension solids, again as expected on thermodynamic grounds. There is one minor yet interesting exception to the thermodynamic pattern: In spite of the slightly lower surface tension of siliconized glass, the extent of protein adsorption is slightly higher to Teflon than to siliconized glass. This result is attributed to the theoretically well known phenomenon of “screening”.

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Metadata

Authors
Absolom, D. R., Zingg, W., & Neumann, A. W.
Venue
Journal of Biomedical Materials Research
Publisher
Wiley
Published
1987-02
Volume
21
Issue
2
Pages
161-171
ISSN
  • 0021-9304 (ISSN-L)
  • 1097-4636
OpenAlex
W1997596842
Cited by
259
References
10
FWCI
7.71
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Protein adsorption to polymer particles: Role of surface properties. https://app.cochat.ai/papers/10.1002/jbm.820210202
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Absolom, D. R., Zingg, W., & Neumann, A. W. (1987). Protein adsorption to polymer particles: Role of surface properties. Journal of Biomedical Materials Research. https://doi.org/10.1002/jbm.820210202

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