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Cited by 76Polymer Surface Interaction StudiesOrthopaedic implants and arthroplastyImmune Response and Inflammation

Plasma protein adsorbed biomedical polymers: activation of human monocytes and induction of interleukin 1

Bonfield, Tracey L., Colton, Erica, Anderson, James M.·1989·Journal of Biomedical Materials Research
DOI 10.1002/jbm.820230602
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Abstract

These studies involved the evaluation of human monocyte/macrophage activation by biomedical polymers coated with human blood proteins. The biomedical polymers were polyethylene, polydimethylsiloxane, woven Dacron fabric, expanded polytetrafluoroethylene, Biomer, and tissue culture treated polystyrene as the control. They were adsorbed with human blood proteins: albumin, fibrinogen, fibronectin, hemoglobin, and gamma globulin. The protein adsorbed polymers were evaluated for their potential to activate the monocyte/macrophage cellular population in vitro as assessed by the induction of the monocyte/macrophage inflammatory mediator, Interleukin 1 (IL1). Suppression of IL1 was observed when protein adsorbed polymers were compared to the appropriate protein adsorbed control. Protein adsorbed polymers, when compared to polymers without protein adsorption, stimulated IL1 production. The data presented in this manuscript show the level of induction and secretion of IL1 was dependent on the biomedical polymer and the protein adsorbed, as well as the requirement of lipopolysaccharide. These results show differential interactions occur between the proteins, monocytes/macrophages, and biomedical polymers which alter activation and induction of IL1.

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Crossref · 10.1002/jbm.820230602

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  • IL-1 secretion was dependent on the biomedical polymer and the protein pre-adsorbed on the surface.

    “IL-1 secretion was found to be dependent on the biomedical polymer and the protein pre-adsorbed on the surface.[104]”

    From Foreign body reaction to biomaterials (2008) · cites this paper as [104]

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Authors
Bonfield, T. L., Colton, E., & Anderson, J. M.
Affiliations
Case Western Reserve University (US)
Corresponding author
Anderson, James M.
ORCID
Venue
Journal of Biomedical Materials Research
Publisher
Wiley
Published
1989-06
Volume
23
Issue
6
Pages
535-548
ISSN
  • 0021-9304 (ISSN-L)
  • 1097-4636
DOI
10.1002/jbm.820230602
OpenAlex
W2022481471
Cited by
76
References
1
Citations by year
2023: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2016: 3 · 2014: 1 · 2012: 4
FWCI
4.98
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5583 d)
Locations
  • Journal of Biomedical Materials Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (HL25239, HL-27277, HL 33849)
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
protein adsorption, biomedical polymers, monocyte activation, macrophage activation, interleukin-1, plasma proteins, polyethylene, polydimethylsiloxane, expanded polytetrafluoroethylene, Biomer, albumin, fibrinogen, fibronectin, hemoglobin, gamma globulin, lipopolysaccharide, biocompatibility
MeSH terms
Animals, Biopolymers, Blood Proteins, Cells, Cultured, Humans, Interleukin-1, Macrophage Activation, Male, Monocytes, Macromolecular Substances, Mice

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