The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Use of polyphosphazenes for skeletal tissue regeneration
Abstract
The hydrolytically unstable polyphosphazenes, poly [(imidazolyl) (methylphenoxy) phosphazenes] and poly [ethyl (glycinato) (methylphenoxy) phosphazenes], were studied as potential polymeric supports for cells in tissue regeneration. For bone repair, their specific function would be to support osteoblast growth, forming a bone–polymer matrix. MC3T3–E1 cells (an osteogenic cell line) were seeded onto polymer matrices and cell adhesion and growth as well as polymer degradation were examined. Both imidazoly‐ and ethyl glycinato‐substituted polyphosphazenes supported the growth of MC3T3–E1 cells. An increase in the content of the imidazolyl side group resulted in a reduction in cell attachment and growth on the polymer surface and an increase in the rate of degradation of the polymer. In contrast, substitution with the ethyl glycinato group favored increased cell adhesion and growth and also an increase in the rate of degradation of the polymers. Thus, the polyphosphazenes represent a system whereby cell growth and degradation can be modulated by varying the nature of the hydrolytically unstable side chain. This in vitro evaluation suggests that the polyphosphazenes may be suitable candidate biomaterials for the construction of a cell–polymer matrix for tissue regeneration. © 1993 John Wiley & Sons, Inc.
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In the citing paper
“Increase in imidazolyl side groups resulted in a reduction in cell attachment and growth on the polymer surface and an increase in the rate of degradation of the polymer.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)
In the citing paper
“In contrast, substitution with ethylglycinato group favoured increased cell adhesion and growth and also an increase in the rate of degradation of the polymers.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)
In the citing paper
“In contrast, substitution with ethylglycinato group favoured increased cell adhesion and growth and also an increase in the rate of degradation of the polymers.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)
In the citing paper
“Both materials supported the growth of MC3T3-E1, an osteogenic cell line.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)
In the citing paper
“Increase in imidazolyl side groups resulted in a reduction in cell attachment and growth on the polymer surface and an increase in the rate of degradation of the polymer.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)
Citations
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Metadata
- Authors
- Laurencin, C. T., Norman, M. E., Elgendy, H. M., El‐Amin, S. F., Allcock, H. R., Pucher, S. R., & Ambrosio, A. A.
- Affiliations
- Harvard University (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Pennsylvania State University (US)
- Corresponding author
- Laurencin, Cato T.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1993-07
- Volume
- 27
- Issue
- 7
- Pages
- 963-973
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W2082515652
- Cited by
- 179
- References
- 31
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 10 · 2013: 13 · 2012: 3
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- polyphosphazenes, bone regeneration, osteoblast proliferation, MC3T3-E1 cells, cell adhesion, polymer degradation, biomaterials
- MeSH terms
- Animals, Bone Regeneration, Cell Adhesion, Cell Division, Cell Line, Organophosphorus Compounds, Polymers, Mice
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