The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Use of polyphosphazenes for skeletal tissue regeneration
Abstract
The hydrolytically unstable polyphosphazenes, poly [(imidazolyl) (methylphenoxy) phosphazenes] and poly [ethyl (glycinato) (methylphenoxy) phosphazenes], were studied as potential polymeric supports for cells in tissue regeneration. For bone repair, their specific function would be to support osteoblast growth, forming a bone–polymer matrix. MC3T3–E1 cells (an osteogenic cell line) were seeded onto polymer matrices and cell adhesion and growth as well as polymer degradation were examined. Both imidazoly‐ and ethyl glycinato‐substituted polyphosphazenes supported the growth of MC3T3–E1 cells. An increase in the content of the imidazolyl side group resulted in a reduction in cell attachment and growth on the polymer surface and an increase in the rate of degradation of the polymer. In contrast, substitution with the ethyl glycinato group favored increased cell adhesion and growth and also an increase in the rate of degradation of the polymers. Thus, the polyphosphazenes represent a system whereby cell growth and degradation can be modulated by varying the nature of the hydrolytically unstable side chain. This in vitro evaluation suggests that the polyphosphazenes may be suitable candidate biomaterials for the construction of a cell–polymer matrix for tissue regeneration. © 1993 John Wiley & Sons, Inc.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Increase in imidazolyl side groups resulted in a reduction in cell attachment and growth on the polymer surface and an increase in the rate of degradation of the polymer.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)
In the citing paper
“In contrast, substitution with ethylglycinato group favoured increased cell adhesion and growth and also an increase in the rate of degradation of the polymers.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)
In the citing paper
“In contrast, substitution with ethylglycinato group favoured increased cell adhesion and growth and also an increase in the rate of degradation of the polymers.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)
In the citing paper
“Both materials supported the growth of MC3T3-E1, an osteogenic cell line.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)
In the citing paper
“Increase in imidazolyl side groups resulted in a reduction in cell attachment and growth on the polymer surface and an increase in the rate of degradation of the polymer.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)
Citations
Cites
Tissue Engineering by Cell Transplantation Using Degradable Polymer Substrates
Griffith, L. G., Vacanti, J. P., Vacanti, C. A., Ingber, D. E., Mooney, D. J., & Langer, R. (1991) · Journal of Biomechanical Engineering · doi:10.1115/1.2891228 · Cited by 595
Synthetic Polymers Seeded with Chondrocytes Provide a Template for New Cartilage Formation
Vacanti, C. A., Langer, R., Schloo, B. L., & Vacanti, J. P. (1991) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199111000-00001 · Cited by 548
Establishment of a clonal osteogenic cell line from newborn mouse calvaria
Kodama, H.-A., Amagai, Y., Sudo, H., Kasai, S., & Yamamoto, S. (1981) · Japanese Journal of Oral Biology · doi:10.2330/joralbiosci1965.23.899 · Cited by 506
Biodegradable bone repair materials. Synthetic polymers and ceramics.
Hollinger, J. O., & Battistone, G. C. (1986) · PubMed · Cited by 486
Biodegradable Bone Repair Materials
Hollinger, J. O., & Battistone, G. C. (1986) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198606000-00046 · Cited by 382
Schakenraad, J., Busscher, H. J., Wildevuur, C. R. H., & Arends, J. (1986) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820200609 · Cited by 365
Cellular interactions with synthetic polymer surfaces in culture
Lydon, M. J., Minett, T. W., & Tighe, B. J. (1985) · Biomaterials · doi:10.1016/0142-9612(85)90100-0 · Cited by 263
Mankin, H. J., Gebhardt, M. C., & Tomford, W. W. (1987) · Orthopedic Clinics of North America · doi:10.1016/s0030-5898(20)30391-6 · Cited by 215
Horbett, T. A., Waldburger, J. J., Ratner, B. D., & Hoffman, A. S. (1988) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820220503 · Cited by 208
van der Valk, P., van Pelt, A. W. J., Busscher, H. J., de Jong, H. P., Wildevuur, C. R. H., & Arends, J. (1983) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820170508 · Cited by 206
Research works printed but not linked: 1
- de Visser A. C., 1984, Controlled release from a biodegradable polymeric system based on polyphosphazene, Adv. Biomater., 5, 373
Cited by
Sorted by citations
Biodegradable polymers as biomaterials
Nair, L. S., & Laurencin, C. T. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.017 · Cited by 4,416
Self-citationBiodegradable synthetic polymers for tissue engineering
CSIRO Molecular Science, B. 1., & Gunatillake, P. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a01 · Cited by 1,765
Bone Tissue Engineering: State of the Art and Future Trends
Salgado, A. J., Coutinho, O. P., & Reis, R. L. (2004) · Macromolecular Bioscience · doi:10.1002/mabi.200400026 · Cited by 1,711
Biomedical applications of polymer-composite materials: a review
Ramakrishna, S., Mayer, J., Wintermantel, E., & Leong, K. W. (2001) · Composites Science and Technology · doi:10.1016/s0266-3538(00)00241-4 · Cited by 1,642
Current development of biodegradable polymeric materials for biomedical applications
Song, R., Murphy, M. C., Li, C., Ting, K., Soo, C. B., & Zheng, Z. S. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s165440 · Cited by 931
Metadata
- Authors
- Laurencin, C. T., Norman, M. E., Elgendy, H. M., El‐Amin, S. F., Allcock, H. R., Pucher, S. R., & Ambrosio, A. A.
- Affiliations
- Harvard University (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Pennsylvania State University (US)
- Corresponding author
- Laurencin, Cato T.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1993-07
- Volume
- 27
- Issue
- 7
- Pages
- 963-973
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W2082515652
- Cited by
- 179
- References
- 31
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 10 · 2013: 13 · 2012: 3
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- polyphosphazenes, bone regeneration, osteoblast proliferation, MC3T3-E1 cells, cell adhesion, polymer degradation, biomaterials
- MeSH terms
- Animals, Bone Regeneration, Cell Adhesion, Cell Division, Cell Line, Organophosphorus Compounds, Polymers, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
