The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.
Development of fibroblast‐seeded ligament analogs for ACL reconstruction
Abstract
We fabricated "ligament analogs" in vitro by seeding high-strength resorbable collagen fiber scaffolds with intraarticular (anterior cruciate ligament, ACL) or extraarticular (patellar tendon, PT) rabbit fibroblasts. Fibroblasts attached, proliferated, and secreted new collagen on the ligament analogs in vitro. Fibroblast function depended on the tissue culture substrate (ligament analog vs. tissue culture plate) and the origin of the fibroblasts (ACL vs. PT) PT fibroblasts proliferated more rapidly than ACL fibroblasts when cultured on ligament analogs. Collagen synthesis by ACL and PT fibroblasts was approximately tenfold greater on ligament analogs than on tissue culture plates. The composition, structure, and geometry of the collagen fiber scaffolds may promote collagen synthesis within ligament analogs in vitro. Ligament analogs roughly approximate the structure and strength of native ligament tissue. Ongoing in vivo studies suggest that autogenous fibroblast-seeded ligament analogs remain viable after implantation into the knee joint. With further development, ligament analogs may be useful as implants for ACL reconstruction surgery.
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“To overcome such a time-consuming healing process, which leads to weaker reparative scar tissue, tissue-engineering strategies that involve fibroblasts or stem cell transplantation, gene regulation, and bioengineering have been attempted to enhance ACLR outcomes [13–18].”
Citations
Cites
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1 of the 46 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Fu F. H., 1993, Biomechanics of knee ligaments, J. Bone Jt. Surg, 75, 1716, 10.2106/00004623-199311000-00018 · DOI
- Dunn M. G., 1995, Ligaments of the Knee, 275
Cited by
Sorted by citations
Wang, J. H. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2005.05.011 · Cited by 1,003
Use of mesenchymal stem cells in a collagen matrix for achilles tendon repair
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Mikos, A. G., Herring, S. W., Ochareon, P., Elisseeff, J. H., Lu, H. H., Kandel, R. A., Schöen, F. J., Toner, M., Mooney, D. J., Atala, A., et al. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.3307 · Cited by 598
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Metadata
- Authors
- Dunn, M. G., Liesch, J. B., Tiku, M. L., & Zawadsky, J. P.
- Affiliations
- University of Medicine and Dentistry of New Jersey (US)
- Corresponding author
- Dunn, Michael G.
- ORCID
- Dunn, Michael G.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1995-11
- Volume
- 29
- Issue
- 11
- Pages
- 1363-1371
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W2026173616
- Cited by
- 206
- References
- 46
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 4 · 2013: 10 · 2012: 8
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29ar042230-04)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R29-AR42230)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
- Keywords
- anterior cruciate ligament reconstruction, fibroblast seeding, bioresorbable scaffolds, autologous cell transplantation, collagen synthesis, fibroblast proliferation, tissue engineering, knee joint
- MeSH terms
- Animals, Bioprosthesis, Cell Adhesion, Cell Division, Cells, Cultured, Collagen, Fibroblasts, Ligaments, Male, Patella, Rabbits, Tendons, Anterior Cruciate Ligament
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