Cited by 206Tendon Structure and TreatmentElectrospun Nanofibers in Biomedical ApplicationsKnee injuries and reconstruction techniques

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Development of fibroblast‐seeded ligament analogs for ACL reconstruction

Dunn, Michael G., Liesch, Janice B., Tiku, Moti L., Zawadsky, Joseph P.·1995·Journal of Biomedical Materials Research

DOI 10.1002/jbm.820291107

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Abstract

We fabricated "ligament analogs" in vitro by seeding high-strength resorbable collagen fiber scaffolds with intraarticular (anterior cruciate ligament, ACL) or extraarticular (patellar tendon, PT) rabbit fibroblasts. Fibroblasts attached, proliferated, and secreted new collagen on the ligament analogs in vitro. Fibroblast function depended on the tissue culture substrate (ligament analog vs. tissue culture plate) and the origin of the fibroblasts (ACL vs. PT) PT fibroblasts proliferated more rapidly than ACL fibroblasts when cultured on ligament analogs. Collagen synthesis by ACL and PT fibroblasts was approximately tenfold greater on ligament analogs than on tissue culture plates. The composition, structure, and geometry of the collagen fiber scaffolds may promote collagen synthesis within ligament analogs in vitro. Ligament analogs roughly approximate the structure and strength of native ligament tissue. Ongoing in vivo studies suggest that autogenous fibroblast-seeded ligament analogs remain viable after implantation into the knee joint. With further development, ligament analogs may be useful as implants for ACL reconstruction surgery.

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Authors: Dunn, M. G., Liesch, J. B., Tiku, M. L., & Zawadsky, J. P.
Affiliations: University of Medicine and Dentistry of New Jersey (US)
Corresponding author: Dunn, Michael G.
ORCID: Dunn, Michael G.
Venue: Journal of Biomedical Materials Research
Publisher: Wiley
Published: 1995-11
Volume: 29
Issue: 11
Pages: 1363-1371
ISSN: 0021-9304 (ISSN-L)
1097-4636
DOI: 10.1002/jbm.820291107
OpenAlex: W2026173616
Cited by: 206
References: 46
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 4 · 2013: 10 · 2012: 8
FWCI: 2.04
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3239 d)
Locations: Journal of Biomedical Materials Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r29ar042230-04)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R29-AR42230)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
Keywords: anterior cruciate ligament reconstruction, fibroblast seeding, bioresorbable scaffolds, autologous cell transplantation, collagen synthesis, fibroblast proliferation, tissue engineering, knee joint
MeSH terms: Animals, Bioprosthesis, Cell Adhesion, Cell Division, Cells, Cultured, Collagen, Fibroblasts, Ligaments, Male, Patella, Rabbits, Tendons, Anterior Cruciate Ligament

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Development of fibroblast‐seeded ligament analogs for ACL reconstruction

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