Mesenchymal stem cell interacted with PLCL braided scaffold coated with poly‐l‐lysine/hyaluronic acid for ligament tissue engineering
Open accessAbstract
The challenge of finding an adapted scaffold for ligament tissue engineering remains unsolved after years of researches. A technology to fabricate a multilayer braided scaffold with flexible and elastic poly (l‐lactide‐co‐caprolactone) (PLCL 85/15) has been recently pioneered by our team. In this study, polyelectrolyte multilayer films (PEM) with poly‐l‐lysine (PLL)/ hyaluronic acid (HA) were deposited on this scaffold. After PEM modification, polygonal (PLL) and particle‐like (HA) structures were present on the braided scaffold with no significant variation of fibers Young's modulus. Wharton's jelly mesenchymal stem cells (WJ‐MSC) and bone marrow mesenchymal stem cells (BM‐MSC) showed good metabolic activity on scaffolds. They presented a spindled shape along the fiber longitudinal direction, and crossed the fibers to form cell bridges. Collagen type I, collagen type III, and tenascin‐C secreted by MSCs were detected on day 14. Moreover, one‐layer modified scaffold presented increased chemotaxis. As a conclusion, our results indicate that this braided PLCL scaffold with one‐layer PEM modification shows inspiring potential with satisfying mechanical properties and biocompatibility. It opens new perspectives to incorporate growth factors within PEM‐modified braided PLCL scaffold for ligament tissue engineering and to recruit endogenous cells after implantation. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3042–3052, 2018.
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PLCL scaffold for ligament tissue engineering braided with 16 PLCL fibers, surface deposited with polyelectrolyte membrane of PLL and HA, promotes growth of Wharton's glial mesenchymal stem cells and bone marrow mesenchymal stem cells; cells form spindle-shaped fibrous structure with good chemotaxis.
“Liu et al. developed a PLCL scaffold for ligament tissue engineering. The scaffold is braided with 16 PLCL fibers. The surface of this PLCL scaffold was deposited with a polyelectrolyte membrane of polyl-lysine (PLL) and hyaluronic acid (HA), which could promote the growth of Wharton’s glial mesenchymal stem cells and bone marrow mesenchymal stem cells. The cells formed a spindle-shaped fibrous”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [214]
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References 42 · Cited by 35
- Authors
- Liu, X., Laurent, C., Du, Q., Targa, L., Cauchois, G., Chen, Y., Wang, X., & de Isla, N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Wuhan University (CN)
- CNRS UMR 7365 ‐Université de Lorraine Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA) Vandœuvre‐lès‐Nancy France
- Corresponding author
- Liu, Xing
- Venue
- Journal of Biomedical Materials Research Part A
- Publisher
- Wiley
- Published
- 2018-09-07
- Volume
- 106
- Issue
- 12
- Pages
- 3042-3052
- ISSN
- 1549-3296 (ISSN-L)
- 1552-4965
- OpenAlex
- W2891679076
- Cited by
- 35
- References
- 42
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 2
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Journal of Biomedical Materials Research Part A (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- China Scholarship Council
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Keywords
- ligament tissue engineering, poly(L-lactide-co-ε-caprolactone), polyelectrolyte multilayers, poly-L-lysine, hyaluronic acid, mesenchymal stem cells, Wharton's jelly mesenchymal stem cells, bone marrow mesenchymal stem cells, scaffold surface modification, cell adhesion, collagen secretion, tenascin-C, chemotaxis, biocompatibility
- MeSH terms
- Cells, Cultured, Humans, Hyaluronic Acid, Ligaments, Polyesters, Polylysine, Coated Materials, Biocompatible, Tissue Engineering, Tissue Scaffolds, Elastic Modulus, Mesenchymal Stem Cells, Wharton Jelly
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