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Cited by 401

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Chitosan membrane as a wound‐healing dressing: Characterization and clinical application

Azad, Abul Kalam, Sermsintham, Niwet, Chandrkrachang, Suwalee, Stevens, Willem Frans·2004·Journal of Biomedical Materials Research Part B: Applied Biomaterials

Abstract

Chitosan prepared from natural biopolymer chitin and cast into membranes has been tested as wound dressing at the skin‐graft donor site in patients. Bactigras, a commonly used impregnated tulle gras bandage, served as a control. Chitosan membrane, prepared with a 75% degree of deacetylation and a thickness of 10 μm, was used in nonmesh or mesh form. The progress in wound healing was compared by clinical and histological examination. Itching and pain sensitivity of the wound dressed area was scored with the use of a visual analogue scale. Mesh chitosan membrane in contrast to the nonmesh membrane allowed blood to ooze into the surrounding gauze. After 10 days, the chitosan‐dressed area had been healed more promptly as compared with the Bactigras dressed area. Moreover, the chitosan mesh membrane showed a positive effect on the re‐epithelialization and the regeneration of the granular layer. The data confirm that chitosan mesh membrane is a potential substitute for human wound dressing. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 69B: 216–222, 2004

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Metadata

Authors
Azad, A. K., Sermsintham, N., Chandrkrachang, S., & Stevens, W. F.
Venue
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Publisher
Wiley
Published
2004-02-09
Volume
69B
Issue
2
Pages
216-222
ISSN
  • 1552-4973 (ISSN-L)
  • 1552-4981
OpenAlex
W2154967053
Cited by
401
References
18
FWCI
6.29
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Chitosan membrane as a wound‐healing dressing: Characterization and clinical application. https://app.cochat.ai/papers/10.1002/jbm.b.30000
The paper
Azad, A. K., Sermsintham, N., Chandrkrachang, S., & Stevens, W. F. (2004). Chitosan membrane as a wound‐healing dressing: Characterization and clinical application. Journal of Biomedical Materials Research Part B: Applied Biomaterials. https://doi.org/10.1002/jbm.b.30000

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