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Cited by 114Bone health and osteoporosis researchHIV-related health complications and treatmentsMenopause: Health Impacts and Treatments

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

In Obese Postmenopausal Women, Bone Microarchitecture and Strength Are Not Commensurate to Greater Body Weight: The Os des Femmes de Lyon (OFELY) Study

Sornay-Rendu, Elisabeth, Boutroy, Stephanie, Vilayphiou, Nicolas, Claustrat, Bruno, Chapurlat, Roland D·2013·Journal of Bone and Mineral Research
DOI 10.1002/jbmr.1880
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Abstract

Obesity is associated with higher areal bone density (aBMD) but its protective effect on the risk of fracture is controversial. We aimed to analyze bone microarchitecture and biomechanical properties in obese (OB) postmenopausal French women compared with normal weight (NW) women. A matched case-control study from the Os des Femmes de Lyon (OFELY) cohort was conducted in 63 OB women (body mass index [BMI] > 30, mean age 69 ± 8 years) age-matched with 126 NW women (19 ≤ BMI ≤ 25). Bone architecture was measured with high-resolution pQCT at the distal radius and tibia and bone strength was assessed by micro–finite element analysis (µFEA). aBMD, total body fat mass (FM) and lean mass (LM) were measured by dual-energy X-ray absorptiometry (DXA). aBMD was 15% higher at the total hip in OB compared with NW women. At the radius, OB had 13% and 14% higher volumetric total and trabecular bone densities, 11% higher cortical thickness, 13% greater trabecular number, and 22% lower distribution of trabecular separation compared with NW (p adjusted for height, physical activity, and medication use, <0.01 for all). Differences of a similar magnitude were found at the distal tibia. At both sites, µFEA showed significant higher values of bone strength in OB compared to controls. After normalizing values for individual body weight, we observed that all the parameters were relatively lower in OB compared to NW women. The increase of FM was fourfold greater than the increase of LM in OB. The effect of FM on bone parameters was more pronounced at the tibia compared to the non–weight-bearing site. Nevertheless, the coefficients of correlation were about one-half of those of LM for the biomechanical parameters. We conclude that higher absolute values of bone densities, cortical and trabecular architecture, and strength indices were not in proportion to the excess of BMI and particularly of FM in obese postmenopausal French women.

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Research works printed but not linked: 1

  1. Ensrud, 2003, Cummings SR; Study of Osteoporotic Fractures Research Group, Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women J Am Geriatr Soc., 51, 1740

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Metadata

Authors
Sornay-Rendu, E., Boutroy, S., Vilayphiou, N., Claustrat, B., & Chapurlat, R. D.
Affiliations
  • INSERM Research Unit 1033Hospices Civils de Lyon, Université de LyonLyonFrance
  • Inserm (FR)
ORCID
Venue
Journal of Bone and Mineral Research
Publisher
Oxford University Press (OUP)
Published
2013-01-31
Volume
28
Issue
7
Pages
1679-1687
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
DOI
10.1002/jbmr.1880
OpenAlex
W1607536434
Cited by
114
References
51
Citations by year
2026: 2 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 13 · 2021: 10 · 2020: 5 · 2019: 12 · 2018: 8 · 2017: 11 · 2016: 7 · 2015: 11 · 2014: 11 · 2013: 2
FWCI
10.58
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Journal of Bone and Mineral Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Mutuelle Générale de l'Education Nationale
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
obesity, postmenopausal women, bone microarchitecture, bone strength, areal bone mineral density, fat mass, lean body mass, trabecular bone, cortical thickness, distal radius, distal tibia, micro-finite element analysis, fracture risk, body weight
MeSH terms
Adult, Aged, Aged, 80 and over, Body Weight, Female, France, Humans, Middle Aged, Obesity, Radius, Retrospective Studies, Tibia, Absorptiometry, Photon, Bone Density, Postmenopause

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