Decreased bioavailability of vitamin D in obesity
Open accessAbstract
Background Obesity is associated with vitamin D insufficiency and secondary hyperparathyroidism.Objective This study assessed whether obesity alters the cutaneous production of vitamin D(3) (cholecalciferol) or the intestinal absorption of vitamin D(2) (ergocalciferol).Design Healthy, white, obese [body mass index (BMI; in kg/m(2)) > or = 30] and matched lean control subjects (BMI </= 25) received either whole-body ultraviolet radiation or a pharmacologic dose of vitamin D(2) orally.Results Obese subjects had significantly lower basal 25-hydroxyvitamin D concentrations and higher parathyroid hormone concentrations than did age-matched control subjects. Evaluation of blood vitamin D(3) concentrations 24 h after whole-body irradiation showed that the incremental increase in vitamin D(3) was 57% lower in obese than in nonobese subjects. The content of the vitamin D(3) precursor 7-dehydrocholesterol in the skin of obese and nonobese subjects did not differ significantly between groups nor did its conversion to previtamin D(3) after irradiation in vitro. The obese and nonobese subjects received an oral dose of 50000 IU (1.25 mg) vitamin D(2). BMI was inversely correlated with serum vitamin D(3) concentrations after irradiation (r = -0.55, P: = 0.003) and with peak serum vitamin D(2) concentrations after vitamin D(2) intake (r = -0.56, P: = 0.007).Conclusions Obesity-associated vitamin D insufficiency is likely due to the decreased bioavailability of vitamin D(3) from cutaneous and dietary sources because of its deposition in body fat compartments.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Emerging data support a direct relationship between bone and fat.
“Emerging data also support a direct relationship between bone and fat16, 17.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [16]
Cites
Experimental Design: Procedures for the Behavioral Sciences
Kirk, R. (2013) · doi:10.4135/9781483384733 · Cited by 8,539 · see citing works
Aging decreases the capacity of human skin to produce vitamin D3.
MacLaughlin, J. A., & Holick, M. F. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112134 · Cited by 1,442 · see citing works
Self-citationExperimental design: Procedures for the behavioral sciences (3rd ed.).
Kirk, R. E. (1995) · Cited by 788 · see citing works
Photosynthesis of Previtamin D 3 in Human Skin and the Physiologic Consequences
Holick, M. F., MacLaughlin, J. A., Clark, M. B., Holick, S. A., Potts, J. T. J., Anderson, R. R., Blank, I. H., Parrish, J. A., & Elias, P. M. (1980) · Science · doi:10.1126/science.6251551 · Cited by 778 · see citing works
Self-citationEvidence for alteration of the vitamin D-endocrine system in obese subjects.
Bell, N. H., Epstein, S., Greene, A. S., Shary, J., Oexmann, M. J., & Shaw, S. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111971 · Cited by 685 · see citing works
Sunscreens Suppress Cutaneous Vitamin D3Synthesis*
Matsuoka, L. Y., IDE, L., Wortsman, J., MacLaughlin, J. A., & Holick, M. F. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-6-1165 · Cited by 600 · see citing works
Self-citationLow circulating vitamin D in obesity
Liel, Y., Ulmer, E., Shary, J., Hollis, B. W., & Bell, N. H. (1988) · Calcified Tissue International · doi:10.1007/bf02555135 · Cited by 388 · see citing works
Racial Pigmentation and the Cutaneous Synthesis of Vitamin D
Matsuoka, L. Y. (1991) · Archives of Dermatology · doi:10.1001/archderm.1991.04510010104011 · Cited by 302 · see citing works
Self-citationEffects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D
Need, A. G., Morris, H., Horowitz, M., & Nordin, C. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.6.882 · Cited by 301 · see citing works
Vitamin D status and bone histomorphometry in gross obesity
Compston, J. E., Vedi, S., Ledger, J. E., Webb, A., Gazet, J. C., & Pilkington, T. R. (1981) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.11.2359 · Cited by 249 · see citing works
Vitamin D absorption in healthy subjects and in patients with intestinal malabsorption syndromes
Lo, C., Paris, P., Clemens, T. L., Nolan, J. M., & Holick, M. F. (1985) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/42.4.644 · Cited by 216 · see citing works
Self-citationMetabolism of Vitamin D3-3H in Human Subjects: Distribution in Blood, Bile, Feces, and Urine*
Avioli, L. V., Lee, S. W., McDonald, J. E., Lund, J., & DeLuca, H. F. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105605 · Cited by 178 · see citing works
Bone metabolism in obesity: changes related to severe overweight and dietary weight reduction
Hyldstrup, L., Andersen, T., McNair, P., Breum, L., & Transbøl, L. (1993) · European Journal of Endocrinology · doi:10.1530/acta.0.1290393 · Cited by 144 · see citing works
A method for the determination of the circulating concentration of 1,25-dihydroxyvitamin D
Chen, T. C., Turner, A. K., & Holick, M. F. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90068-v · Cited by 133 · see citing works
Self-citationMethods for the determination of the circulating concentration of 25-hydroxyvitamin D
Chen, T. C., Turner, A. K., & Holick, M. F. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90067-u · Cited by 115 · see citing works
Self-citationHey, H., Stokholm, K. H., Lund, B., Lund, B., & Sørensen, O. H. (1982) · PubMed · Cited by 89 · see citing works
Andersen, T., McNair, P., Fogh‐Andersen, N., Nielsen, T. T., Hyldstrup, L., & Transbøl, I. (1986) · Metabolism · doi:10.1016/0026-0495(86)90116-2 · Cited by 66 · see citing works
Evidence of a probable role for 25-hydroxyvitamin D in the regulation of human calcium metabolism
Bell, N. H., Epstein, S., Shary, J., Greene, V. S., Oexmann, M. J., & Shaw, S. (1988) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650030503 · Cited by 61 · see citing works
A method for the determination of the circulating concentration of vitamin D
Chen, T. C., Turner, A. K., & Holick, M. F. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90078-y · Cited by 45 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Holick, M. F., Binkley, N., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., Murad, M. H., & Weaver, C. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0385 · Cited by 10,556 · see citing works
Self-citationClinician’s Guide to Prevention and Treatment of Osteoporosis
Cosman, F., de Beur, S. J., LeBoff, M. S., Lewiecki, E. M., Tanner, B., Randall, S., & Lindsay, R. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2794-2 · Cited by 4,149 · see citing works
“This regimen should be followed by maintenance therapy of 1500–2000 IU/day or whatever dose is needed to maintain the target blood level [37, 38].”
BackgroundHolick, M. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1678s · Cited by 2,768 · see citing works
Self-citationVitamin D deficiency: a worldwide problem with health consequences
Holick, M. F., & Chen, T. C. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.1080s · Cited by 2,689 · see citing works
Self-citationHigh Prevalence of Vitamin D Inadequacy and Implications for Health
Holick, M. F. (2006) · Mayo Clinic Proceedings · doi:10.4065/81.3.353 · Cited by 2,008 · see citing works
Self-citationThe Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis
Pittas, A. G., Lau, J., Hu, F. B., & Dawson‐Hughes, B. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0298 · Cited by 2,020 · see citing works
Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
Holick, M. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.3.362 · Cited by 1,665 · see citing works
Self-citationThe vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention
Holick, M. F. (2017) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-017-9424-1 · Cited by 1,580 · see citing works
Self-citationThe clinician's guide to prevention and treatment of osteoporosis
LeBoff, M. S., Greenspan, S. L., Insogna, K. L., Lewiecki, E. M., Saag, K. G., Singer, A. J., & Siris, E. S. (2022) · Osteoporosis International · doi:10.1007/s00198-021-05900-y · Cited by 1,487 · see citing works
Vitamin D Deficiency in Children and Its Management: Review of Current Knowledge and Recommendations
Misra, M., Pacaud, D., Petryk, A., Collett‐Solberg, P. F., & Kappy, M. S. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1894 · Cited by 1,398 · see citing works
25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population
Melamed, M. L., Michos, E. D., Post, W. S., & Astor, B. C. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.15.1629 · Cited by 1,213 · see citing works
Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis
Olsson, T. P., Barcellos, L. F., & Alfredsson, L. S. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.187 · Cited by 1,184 · see citing works
Sunlight and Vitamin D: A global perspective for health
Wacker, M., & Holick, M. F. (2013) · Dermato-Endocrinology · doi:10.4161/derm.24494 · Cited by 1,156 · see citing works
Self-citationDemographic Differences and Trends of Vitamin D Insufficiency in the US Population, 1988-2004
Ginde, A. A., Liu, M. C., & Camargo, C. A. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.604 · Cited by 1,120 · see citing works
Childhood obesity and adult morbidities
Biro, F. M., & Wien, M. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28701b · Cited by 1,098 · see citing works
Prospective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality in Men
Giovannucci, E. L., Liu, Y., Rimm, E. B., Hollis, B. W., Fuchs, C. S., Stampfer, M. J., & Willett, W. C. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj101 · Cited by 1,041 · see citing works
Vimaleswaran, K. S., Berry, D. J., Lu, C., Tikkanen, E., Pilz, S., Hiraki, L. T., Cooper, J. D., Dastani, Z., Li, R., Houston, D. K., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001383 · Cited by 1,046 · see citing works
The Role of Vitamin D in Cancer Prevention
Garland, C. F., Garland, F. C., Gorham, E. D., Lipkin, M., Newmark, H. L., Mohr, S. B., & Holick, M. F. (2005) · American Journal of Public Health · doi:10.2105/ajph.2004.045260 · Cited by 1,032 · see citing works
Self-citationNesby-O’Dell, S., Scanlon, K. S., Cogswell, M. E., Gillespie, C., Hollis, B. W., Looker, A. C., Allen, C., Doughertly, C., Gunter, E. W., & Bowman, B. A. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.1.187 · Cited by 1,001 · see citing works
Holick, M. F., Siris, E. S., Binkley, N., Beard, M. K., Khan, A., Katzer, J. T., Petruschke, R. A., Chen, E., & de Papp, A. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2364 · Cited by 886 · see citing works
Self-citationVitamin D in preventive medicine: are we ignoring the evidence?
Zittermann, A. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2003837 · Cited by 877 · see citing works
Prevalence of Vitamin D Deficiency Among Healthy Adolescents
Gordon, C. M., DePeter, K. C., Feldman, H. A., Grace, E., & Emans, S. J. (2004) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.158.6.531 · Cited by 877 · see citing works
Obesity and vitamin <scp>D</scp> deficiency: a systematic review and meta‐analysis
Pereira‐Santos, M., Costa, P. R. F., Assis, A. M. O., Santos, C. A. S. T., & Santos, D. B. (2015) · Obesity Reviews · doi:10.1111/obr.12239 · Cited by 858 · see citing works
Martins, D., Wolf, M. S., Pan, D., Zadshir, A., Tareen, N. G., Thadhani, R., Felsenfeld, A. J., Levine, B. S., Mehrotra, R., & Norris, K. C. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.11.1159 · Cited by 828 · see citing works
Vitamin D supplementation for women during pregnancy
De‐Regil, L. M., Palacios, C. S., Lombardo, L. K., & Peña‐Rosas, J. P. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008873.pub3 · Cited by 768 · see citing works
The Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement
Rosen, C. J., Adams, J. S., Bikle, D. D., Black, D. M., Demay, M. B., Manson, J. E., Murad, M. H., & Kovács, C. S. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1000 · Cited by 764 · see citing works
Hyppönen, E., & Power, C. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.860 · Cited by 756 · see citing works
IOF position statement: vitamin D recommendations for older adults
Dawson‐Hughes, B., Mithal, A., Bonjour, J. ‐., Boonen, S., Burckhardt, P., Fuleihan, G. E., Josse, R. G., Lips, P. T. A. M., Morales‐Torres, J., & Yoshimura, N. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1285-3 · Cited by 747 · see citing works
Vitamin D-effects on skeletal and extraskeletal health and the need for supplementation
Wacker, M., & Holick, M. (2013) · Nutrients · doi:10.3390/nu5010111 · Cited by 733 · see citing works
Self-citationLee, J. H., O’Keefe, J. H., Bell, D. S. H., Hensrud, D. D., & Holick, M. F. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.08.050 · Cited by 732 · see citing works
Self-citationNeuroendocrinology of the Skin1
Slominski, A., & Wortsman, J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0410 · Cited by 727 · see citing works
Self-citationObesity in autoimmune diseases: Not a passive bystander
Versini, M., Jeandel, P.-Y., Rosenthal, E., & Shoenfeld, Y. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.07.001 · Cited by 694 · see citing works
Prevalence of Severe Hypovitaminosis D in Patients With Persistent, Nonspecific Musculoskeletal Pain
Plotnikoff, G. A., & Quigley, J. M. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.12.1463 · Cited by 691 · see citing works
Silverberg, S. J., Lewiecki, E. M., Mosekilde, L., Peacock, M., & Rubin, M. R. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1760 · Cited by 683 · see citing works
Snijder, M. B., van Dam, R. M., Visser, M., Deeg, D. J. H., Dekker, J. M., Bouter, L. M., Seidell, J. C., & Lips, P. T. A. M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0216 · Cited by 681 · see citing works
Volumetric Dilution, Rather Than Sequestration Best Explains the Low Vitamin D Status of Obesity
Drincic, A., Armas, L. A. G., van Diest, E. E., & Heaney, R. P. (2012) · Obesity · doi:10.1038/oby.2011.404 · Cited by 662 · see citing works
The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults
Parikh, S. J., Edelman, M., Uwaifo, G. I., Freedman, R. J., Semega‐Janneh, M., Reynolds, J. C., & Yanovski, J. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031398 · Cited by 659 · see citing works
Body Fat Content and 25-Hydroxyvitamin D Levels in Healthy Women
Arunabh, S., Pollack, S. Z., Yeh, J. K., & Aloia, J. F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020978 · Cited by 623 · see citing works
Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001–2004
Kumar, J., Muntner, P., Kaskel, F. J., Hailpern, S. M., & Melamed, M. L. (2009) · Pediatrics · doi:10.1542/peds.2009-0051 · Cited by 621 · see citing works
Vitamin D: The "sunshine" vitamin.
Nair, R., & Maseeh, A. (2012) · Europe PMC (PubMed Central) · doi:10.4103/0976-500x.95506 · Cited by 619 · see citing works
The epidemiology of vitamin D and cancer incidence and mortality: A review (United States)
Giovannucci, E. L. (2005) · Cancer Causes & Control · doi:10.1007/s10552-004-1661-4 · Cited by 598 · see citing works
ASMBS Allied Health Nutritional Guidelines for the Surgical Weight Loss Patient
Aills, L., Blankenship, J. D., Buffington, C. K., Furtado, M. M., & Parrott, J. M. (2008) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2008.03.002 · Cited by 595 · see citing works
Vitamin D and multiple sclerosis
Ascherio, A., Munger, K. L., & Simon, K. C. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70086-7 · Cited by 591 · see citing works
The Vitamin D Epidemic and its Health Consequences
Holick, M. F. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2739s · Cited by 579 · see citing works
Self-citationScragg, R. K. R., Sowers, M., & BELL, C. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2007.01.017 · Cited by 577 · see citing works
ESPEN guideline clinical nutrition in neurology
Burgos, R., Bretón, I., Cereda, E., Desport, J. C., Dziewas, R., Genton, L., Gomes, F., Jésus, P., Leischker, A., Muscaritoli, M., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.09.003 · Cited by 571 · see citing works
Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study
Cheng, S. C., Massaro, J. M., Fox, C. S., Larson, M. G., Keyes, M. J., McCabe, E. L., Robins, S. J., O’Donnell, C. J., Hoffmann, U., Jacques, P. F., et al. (2009) · Diabetes · doi:10.2337/db09-1011 · Cited by 522 · see citing works
Zimmermann, P., & Curtis, N. C. (2020) · Archives of Disease in Childhood · doi:10.1136/archdischild-2020-320338 · Cited by 502 · see citing works
Benefits and requirements of vitamin D for optimal health: a review.
Grant, W. B., & Holick, M. F. (2005) · PubMed · Cited by 501 · see citing works
Self-citationVitamin D in the Healthy European Paediatric Population
Braegger, C., Campoy, C., Colomb, V., Décsi, T., Domellöf, M., Fewtrell, M. S., Hojsak, I., Mihatsch, W., Mølgaard, C., Shamir, R., et al. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31828f3c05 · Cited by 496 · see citing works
Vitamin D deficiency: a global perspective
Prentice, A. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00100.x · Cited by 490 · see citing works
Factors Influencing Vitamin D Status
Tsiaras, W. G., & Weinstock, M. A. (2011) · Acta Dermato Venereologica · doi:10.2340/00015555-0980 · Cited by 483 · see citing works
Holick, M. F. (2002) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200202000-00011 · Cited by 477 · see citing works
Self-citationIs vitamin D deficiency to blame for the asthma epidemic?
Litonjua, A. A., & Weiss, S. T. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.08.028 · Cited by 472 · see citing works
Hoogendijk, W. J. G., Lips, P. T. A. M., Dik, M. G., Deeg, D. J. H., Beekman, A. T. F., & Penninx, B. W. J. H. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.5.508 · Cited by 442 · see citing works
Body size and risk of MS in two cohorts of US women
Munger, K. L., Chitnis, T., & Ascherio, A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c0d6e0 · Cited by 441 · see citing works
Targher, G., Bertolini, L., Scala, L., CIGOLINI, M., Zenari, L., Falezza, G., & Arcaro, G. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.04.002 · Cited by 438 · see citing works
Bariatric surgery and long-term nutritional issues
Lupoli, R., Lembo, E., Saldalamacchia, G., Avola, C. K., Angrisani, L., & Capaldo, B. (2017) · World Journal of Diabetes · doi:10.4239/wjd.v8.i11.464 · Cited by 433 · see citing works
Earthman, C. P., Beckman, L. M., Masodkar, K., & Sibley, S. D. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.119 · Cited by 432 · see citing works
Vitamin D: a D-Lightful health perspective
Holick, M. F. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00104.x · Cited by 421 · see citing works
Self-citationPutting cardiovascular disease and vitamin D insufficiency into perspective
Zittermann, A., Schleithoff, S. S., & Koerfer, R. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051544 · Cited by 419 · see citing works
Vitamin D hormone regulates serotonin synthesis. Part 1: Relevance for autism
Patrick, R. P., & Ames, B. N. (2014) · The FASEB Journal · doi:10.1096/fj.13-246546 · Cited by 414 · see citing works
Vitamin D3 Is More Potent Than Vitamin D2 in Humans
Heaney, R. P., Recker, R. R., Grote, J., Horst, R. L., & Armas, L. A. G. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2230 · Cited by 414 · see citing works
McCann, J. C., & Ames, B. N. (2007) · The FASEB Journal · doi:10.1096/fj.07-9326rev · Cited by 409 · see citing works
Assessing the vitamin D status of the US population
Yetley, E. A. D. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.558s · Cited by 408 · see citing works
MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review
Lerchbaum, E., & Obermayer-Pietsch, B. M. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-0984 · Cited by 413 · see citing works
Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism
Speeckaert, M., Huang, G., Delanghe, J. R., & Taes, Y. E. C. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.03.011 · Cited by 480 · see citing works
Prevalence of Vitamin D Deficiency Among Healthy Infants and Toddlers
Gordon, C. M., Feldman, H. A., Sinclair, L., Williams, A. L., Kleinman, P. K., Pérez-Rosselló, J. M., & Cox, J. E. (2008) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.162.6.505 · Cited by 399 · see citing works
Vitamin D and health - The missing vitamin in humans
Chang, S., & Lee, H. (2019) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2019.04.007 · Cited by 398 · see citing works
Age-Related Pharmacokinetic and Pharmacodynamic Changes and Related Risk of Adverse Drug Reactions
Corsonello, A., Pedone, C., & Incalzi, R. A. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790416326 · Cited by 393 · see citing works
25-Hydroxyvitamin D, IGF-1, and Metabolic Syndrome at 45 Years of Age
Hyppönen, E., Boucher, B. J., Berry, D. J., & Power, C. (2007) · Diabetes · doi:10.2337/db07-1122 · Cited by 388 · see citing works
Vitamin D bioavailability: state of the art
Borel, P., Caillaud, D., & Cano, N. J. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.688897 · Cited by 378 · see citing works
Vitamin D supplementation for women during pregnancy
Palacios, C., Kostiuk, L. K., & Peña-Rosas, J. P. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008873.pub4 · Cited by 377 · see citing works
Impact of micronutrient deficiencies on obesity
García, O. P., Long, K. Z., & Rosado, J. L. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00228.x · Cited by 373 · see citing works
Vanlint, S. (2013) · Nutrients · doi:10.3390/nu5030949 · Cited by 371 · see citing works
Lynch, B. M. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0815 · Cited by 374 · see citing works
Blum, M., Dolnikowski, G. G., Seyoum, E., Harris, S. S., Booth, S. L., Peterson, J., Saltzman, E. J., & Dawson‐Hughes, B. (2008) · Endocrine · doi:10.1007/s12020-008-9051-4 · Cited by 366 · see citing works
Television Viewing and Time Spent Sedentary in Relation to Cancer Risk: A Meta-Analysis
Schmid, D., & Leitzmann, M. F. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju098 · Cited by 359 · see citing works
Lu, L., Yu, Z., Pan, A., Hu, F. B., Franco, O. H., Li, H., Li, X., Yang, X., Chen, Y., & Lin, X. (2009) · Diabetes Care · doi:10.2337/dc09-0209 · Cited by 359 · see citing works
Vitamin D status and health correlates among German adults
Hintzpeter, B., Mensink, G., Thierfelder, W., Müller, M., & Scheidt‐Nave, C. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602825 · Cited by 358 · see citing works
Vitamin D in health and disease: Current perspectives
Zhang, R., & Naughton, D. P. (2010) · Nutrition Journal · doi:10.1186/1475-2891-9-65 · Cited by 363 · see citing works
Hypovitaminosis D in developing countries—prevalence, risk factors and outcomes
Arabi, A., Rassi, R. E., & Fuleihan, G. E. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.146 · Cited by 354 · see citing works
Bone Metabolism in Obesity and Weight Loss
Shapses, S. A., & Sukumar, D. (2012) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104655 · Cited by 347 · see citing works
Hedström, A. K., Olsson, T. P., & Alfredsson, L. S. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458512436596 · Cited by 343 · see citing works
The Relationship between Ultraviolet Radiation Exposure and Vitamin D Status
Engelsen, O. (2010) · Nutrients · doi:10.3390/nu2050482 · Cited by 339 · see citing works
Physiological functions of Vitamin D in adipose tissue
Abbas, M. A. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.08.004 · Cited by 336 · see citing works
Vitamin D and cardiovascular health
de la Guía-Galipienso, F., Martínez‐Ferrán, M., Vallecillo, N., Lavie, C. J., Sanchis‐Gomar, F., & Pareja-Galeano, H. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.025 · Cited by 348 · see citing works
Serum 25-Hydroxyvitamin D Concentrations and Risk for Hip Fractures
Cauley, J. A., LaCroix, A. Z., Wu, L., Horwitz, M., Danielson, M. E., Bauer, D. C., Lee, J. S., Jackson, R. D., Robbins, J. A., Wu, C., et al. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-4-200808190-00005 · Cited by 334 · see citing works
Belenchia, A. M., Tosh, A. K., Hillman, L. S., & Peterson, C. A. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.050013 · Cited by 328 · see citing works
Daly, R. M., Gagnon, C., Lu, Z. X., Magliano, D. J., Dunstan, D. W., Sikaris, K. A., Zimmet, P., Ebeling, P. R., & Shaw, J. E. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04320.x · Cited by 327 · see citing works
Self-citationVitamin D Deficiency: Consequence or Cause of Obesity?
Vranić, L., Mikolašević, I., & Milić, S. (2019) · Medicina · doi:10.3390/medicina55090541 · Cited by 331 · see citing works
Barchetta, I., Angelico, F., Ben, M. D., Baroni, M. G., Pozzilli, P., Morini, S., & Cavallo, M. G. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-85 · Cited by 321 · see citing works
Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome
Wehr, E., Pilz, S., Schweighofer, N., Giuliani, A., Kopera, D., Pieber, T. R., & Obermayer-Pietsch, B. M. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0432 · Cited by 325 · see citing works
Physical work capacity in older adults: Implications for the aging worker
Kenny, G. P., Yardley, J. E., Martineau, L., & Jay, O. (2008) · American Journal of Industrial Medicine · doi:10.1002/ajim.20600 · Cited by 317 · see citing works
Prevalence of nutrient deficiencies in bariatric patients
Toh, S. Y., Zarshenas, N., & Jorgensen, J. (2009) · Nutrition · doi:10.1016/j.nut.2009.03.012 · Cited by 315 · see citing works
Vitamin status in morbidly obese patients: a cross-sectional study
Aasheim, E. T., Hofsø, D., Hjelmesæth, J., Birkeland, K. I., & Bøhmer, T. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.362 · Cited by 316 · see citing works
Vitamin D signalling in adipose tissue
Ding, C., Gao, D., Wilding, J. P. H., Trayhurn, P., & Chen, B. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003285 · Cited by 314 · see citing works
Nagpal, J., Pande, J. N., & Bhartia, A. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02636.x · Cited by 313 · see citing works
McGill, A., STEWART, J. M., Lithander, F. E., Strik, C. M., & Poppitt, S. D. (2008) · Nutrition Journal · doi:10.1186/1475-2891-7-4 · Cited by 314 · see citing works
Vitamin D and health in adults in Australia and New Zealand: a position statement
Nowson, C. A., McGrath, J. J., Ebeling, P. R., Haikerwal, A., Daly, R. M., Sanders, K. M., Seibel, M. J., & Mason, R. S. (2012) · The Medical Journal of Australia · doi:10.5694/mja11.10301 · Cited by 311 · see citing works
- Authors
- Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F.
- Affiliations
- SIU Medicine (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 72
- Issue
- 3
- Pages
- 690-693
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2157304718
- Cited by
- 3,204
- References
- 19
- Citations by year
- 2026: 73 · 2025: 89 · 2024: 97 · 2023: 138 · 2022: 190 · 2021: 173 · 2020: 177 · 2019: 158 · 2018: 183 · 2017: 194 · 2016: 189 · 2015: 213 · 2014: 215 · 2013: 231 · 2012: 193
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR369637)
- National Center for Research Resources (MO1 RR 00533, M01RR000533)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Keywords
- obesity, vitamin D bioavailability, vitamin D insufficiency, 25-hydroxyvitamin D, parathyroid hormone, secondary hyperparathyroidism, UV irradiation, 7-dehydrocholesterol, previtamin D3, vitamin D2, body fat storage
- MeSH terms
- Adult, Biological Availability, Cholecalciferol, Ergocalciferols, Humans, Intestinal Absorption, Obesity, Reference Values, Skin, Ultraviolet Rays, Vitamin D, Body Mass Index
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review