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Cited by 183Bone health and osteoporosis researchBone Metabolism and DiseasesHIV-related health complications and treatments

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Bone Geometry, Volumetric Density, Microarchitecture, and Estimated Bone Strength Assessed by HR-pQCT in Adult Patients With Type 1 Diabetes Mellitus

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Shanbhogue, Vikram V, Hansen, Stinus, Frost, Morten, Jørgensen, Niklas Rye, Hermann, Anne Pernille, Henriksen, Jan Erik, Brixen, Kim·2015·Journal of Bone and Mineral Research
DOI 10.1002/jbmr.2573
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Abstract

The primary goal of this cross-sectional in vivo study was to assess peripheral bone microarchitecture, bone strength, and bone remodeling in adult type 1 diabetes (T1D) patients with and without diabetic microvascular disease (MVD+ and MVD–, respectively) and to compare them with age-, gender-, and height-matched healthy control subjects (CoMVD+ and CoMVD–, respectively). The secondary goal was to assess differences in MVD– and MVD+ patients. Fifty-five patients with T1DM (MVD+ group: n = 29) were recruited from the Funen Diabetes Database. Dual-energy X-ray absorptiometry (DXA), high-resolution peripheral quantitative computed tomography (HR-pQCT) of the ultradistal radius and tibia, and biochemical markers of bone turnover were performed in all participants. There were no significant differences in HR-pQCT parameters between MVD– and CoMVD– subjects. In contrast, MVD+ patients had larger total and trabecular bone areas (p = 0.04 and p = 0.02, respectively), lower total, trabecular, and cortical volumetric bone mineral density (vBMD) (p < 0.01, p < 0.04, and p < 0.02, respectively), and thinner cortex (p = 0.03) at the radius, and lower total and trabecular vBMD (p = 0.01 and p = 0.02, respectively) at the tibia in comparison to CoMVD+. MVD+ patients also exhibited lower total and trabecular vBMD (radius p = 0.01, tibia p < 0.01), trabecular thickness (radius p = 0.01), estimated bone strength, and greater trabecular separation (radius p = 0.01, tibia p < 0.01) and network inhomogeneity (radius p = 0.01, tibia p < 0.01) in comparison to MVD– patients. These differences remained significant after adjustment for age, body mass index, gender, disease duration, and glycemic control (average glycated hemoglobin over the previous 3 years). Although biochemical markers of bone turnover were significantly lower in MVD+ and MVD– groups in comparison to controls, they were similar between the MVD+ and MVD– groups. The results of our study suggest that the presence of MVD was associated with deficits in cortical and trabecular bone vBMD and microarchitecture that could partly explain the excess skeletal fragility observed in these patients. © 2015 American Society for Bone and Mineral Research.

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Metadata

Authors
Shanbhogue, V. V., Hansen, S., Frost, M., Jørgensen, N. R., Hermann, A. P., Henriksen, J. E., & Brixen, K.
Affiliations
University of Southern Denmark (DK)
Corresponding author
Shanbhogue, Vikram V
ORCID
Venue
Journal of Bone and Mineral Research
Publisher
Oxford University Press (OUP)
Published
2015-06-10
Volume
30
Issue
12
Pages
2188-2199
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
DOI
10.1002/jbmr.2573
OpenAlex
W2109729276
Cited by
183
References
45
Citations by year
2026: 6 · 2025: 16 · 2024: 15 · 2023: 17 · 2022: 18 · 2021: 15 · 2020: 17 · 2019: 21 · 2018: 23 · 2017: 22 · 2016: 11 · 2015: 2
FWCI
19.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Bone and Mineral Research (publishedVersion)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, other-oa)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
This work was supported by grants from The Research Foundation, Odense University Hospital. MN was supported by a grant from the Danish Council for Independent Research.
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Keywords
type 1 diabetes, diabetic microangiopathy, bone microarchitecture, bone mineral density, bone strength, bone remodeling, bone turnover markers, trabecular bone, cortical bone, bone geometry, ultradistal radius, tibia, trabecular separation, trabecular thickness, network heterogeneity, glycemic control
MeSH terms
Adolescent, Adult, Anthropometry, Bone and Bones, Child, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Female, Humans, Male, Microcirculation, Middle Aged, Radius, Tibia, Tomography, X-Ray Computed, Vascular Diseases, Absorptiometry, Photon, Bone Density, Body Mass Index, Case-Control Studies, Bone Remodeling, Young Adult

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