The Role of Advanced Glycation End Products in Progression and Complications of Diabetes
Abstract
Context Diabetic complications appear to be multifactorial in origin, but in particular, the biochemical process of advanced glycation, which is accelerated in diabetes as a result of chronic hyperglycemia and increased oxidative stress, has been postulated to play a central role in these disorders. Advanced glycation involves the generation of a heterogenous group of chemical moieties known as advanced glycated end products (AGEs), this reaction occurring as a result of a nonenzymatic reaction with glucose interacting with proteins, lipids, and nucleic acids, and involves key intermediates such as methylglyoxal. Evidence synthesis In this review we report on how these AGEs may exert deleterious effects in diabetes, as well as address current strategies to interrupt the formation or action of AGEs. First, AGEs act directly to induce cross-linking of long-lived proteins such as collagen to promote vascular stiffness, and, thus, alter vascular structure and function. Second, AGEs can interact with certain receptors, such as the receptor for AGE, to induce intracellular signaling that leads to enhanced oxidative stress and elaboration of key proinflammatory and prosclerotic cytokines. Over the last decade, a large number of preclinical studies have been performed, targeting the formation and degradation of AGEs, as well as the interaction of these AGEs with receptors such as the receptor for AGE. Conclusion It is hoped that over the next few years, some of these promising therap…
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Chronic hyperglycemia promotes the formation of advanced glycation end products and oxidative stress.
“It has been reported that chronic hyperglycemia could promote the formation of advanced glycation end products and oxidative stress (Goh and Cooper, 2008; Joubert et al., 2019)”
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- Authors
- Goh, S.-Y., & Cooper, M. E.
- Affiliations
- Juvenile Diabetes Research Foundation (AU)
- Corresponding author
- Cooper, Mark E.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-04
- Volume
- 93
- Issue
- 4
- Pages
- 1143-1152
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2074794423
- Cited by
- 987
- References
- 2
- Citations by year
- 2026: 19 · 2025: 42 · 2024: 31 · 2023: 46 · 2022: 48 · 2021: 70 · 2020: 52 · 2019: 52 · 2018: 64 · 2017: 68 · 2016: 64 · 2015: 72 · 2014: 70 · 2013: 64 · 2012: 64
- FWCI
- 33.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- advanced glycation end products, diabetes complications, advanced glycation, receptor for advanced glycation end products, methylglyoxal, oxidative stress, collagen cross-linking, vascular stiffness, inflammatory cytokines, diabetic vascular complications
- MeSH terms
- Receptor for Advanced Glycation End Products, Diabetic Nephropathies, Diabetic Neuropathies, Diabetic Retinopathy, Humans, Receptors, Immunologic, Glycation End Products, Advanced, Disease Progression, Diabetes Complications
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