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Cited by 286Vitamin D Research StudiesBone health and osteoporosis researchParathyroid Disorders and Treatments

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Vitamin D status and sex hormone binding globulin: Determinants of bone turnover and bone mineral density in elderly women

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Ooms, Marcel E., Lips, Paul, Roos, Jan C., van der Vijgh, Wim J. F., Popp-Snijders, Corrie, Bezemer, P. Dick, Bouter, Lex M.·1995·Journal of Bone and Mineral Research
DOI 10.1002/jbmr.5650100806
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Abstract

To examine the relation of the vitamin D status and the remaining estrogen activity with bone turnover and bone mineral density (BMD) in elderly women, BMD was measured at both hips using dual-energy X-ray absorptiometry and at the distal radius using single photon absorptiometry, in 330 healthy women aged 70 and over. Vitamin D metabolites, sex hormone binding globulin (SHBG), PTH(1–84), osteocalcin, alkaline phosphatase, and hydroxyproline and calcium excretion in 2 h fasting urine were measured. Multiple linear regression was used to adjust for potential confounders. In 65% of the women, serum 25(OH)D was below 30 nmol/l. Only values below a threshold for 25(OH)D were negatively related to serum PTH(1–84) (p = 0.02, threshold at 25 nmol/l) and to osteocalcin levels (p = 0.04, threshold at 30 nmol/l). BMD of the femoral neck and trochanter was positively related to serum 25(OH)D (left neck p = 0.001) with thresholds at 30 nmol/l whereas the distal radius was not (p = 0.32). Serum PTH was negatively related to BMD at all measurement sites (all p < 0.001). Serum SHBG, an inverse measure of estrogen activity, was positively related to osteocalcin levels (p = 0.004) and the urinary hydroxyproline/creatinine ratio (p = 0.002) and negatively related to the BMD of the trochanter (left trochanter p = 0.02) and the distal radius (p = 0.001). We conclude that in elderly women, serum 25(OH)D levels below 30 nmol/l are associated with secondary hyperparathyroidism and increased bone turnover. SHBG is positively related to bone turnover. Vitamin D deficiency especially influences BMD of the femoral neck, a cortical area. SHBG mainly influences BMD at the trochanteric region and distal radius, predominantly trabecular areas, which may reflect the effects of remaining estrogen activity.

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Research works printed but not linked: 38

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Metadata

Authors
Ooms, M. E., Lips, P., Roos, J. C., van der Vijgh, W. J. F., Popp-Snijders, C., Bezemer, P. D., & Bouter, L. M.
Affiliations
  • Amsterdam Public Health (NL)
  • Department of Nuclear Medicine, Free University Hospital, Amsterdam, The Netherlands
  • Clinical Research Laboratory, Free University Hospital, Amsterdam, The Netherlands
  • Endocrinological Laboratory, Free University Hospital, Amsterdam, The Netherlands
  • Vrije Universiteit Amsterdam (NL)
Corresponding author
Ooms, Marcel E.
ORCID
Venue
Journal of Bone and Mineral Research
Publisher
Oxford University Press (OUP)
Published
1995-08-01
Volume
10
Issue
8
Pages
1177-1184
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
DOI
10.1002/jbmr.5650100806
OpenAlex
W2113725512
Cited by
286
References
1
Citations by year
2025: 3 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 10 · 2013: 11 · 2012: 10
FWCI
7.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Bone and Mineral Research (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
Praeventiefonds, The Hague, The Netherlands (28-1112-1.)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Keywords
vitamin D status, 25-hydroxyvitamin D, sex hormone-binding globulin, bone turnover, bone mineral density, older women, secondary hyperparathyroidism, parathyroid hormone, osteocalcin, estrogenic activity, urinary hydroxyproline, femoral neck, trochanter, distal radius, osteoporosis
MeSH terms
Aged, Aged, 80 and over, Alkaline Phosphatase, Bone Development, Calcium, Female, Femur, Femur Neck, Humans, Hydroxycholecalciferols, Hydroxyproline, Hyperparathyroidism, Parathyroid Hormone, Radius, Sex Hormone-Binding Globulin, Vitamin D, Vitamin D Deficiency, Absorptiometry, Photon, Bone Density, Osteocalcin, Linear Models

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